Localized micro- and nano-scale remodelling in the diabetic aorta.
Bottom Line: We found that the medial aortic layer underwent significant thickening in diabetic animals but without significant changes in collagen or elastin (abundance).Scanning acoustic microscopy demonstrated that such tissue remodelling was associated with a significant decrease in acoustic wave speed (an indicator of reduced material stiffness) in the inter-lamellar spaces of the vessel wall.This index of decreased stiffness was also linked to increased extracellular protease activity (assessed by semi-quantitative in situ gelatin zymography).
Affiliation: Centre for Materials and Structures, School of Engineering, University of Liverpool, Liverpool L69 3GH, UK. Electronic address: email@example.com.Show MeSH
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Mentions: The resulting SAM images contain sufficient structural information to allow the acoustic wave speed of the elastic lamellae and inter-lamellar regions of the aortic wall to be measured independently (Fig. 1).
Affiliation: Centre for Materials and Structures, School of Engineering, University of Liverpool, Liverpool L69 3GH, UK. Electronic address: firstname.lastname@example.org.