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Hypotension and environmental noise: a replication study.

Lercher P, Widmann U, Thudium J - Int J Environ Res Public Health (2014)

Bottom Line: Hypotension has not been considered as a potential health outcome although in experiments some people also responded to noise with decreases of blood pressure.Other important cofactors (sex, age, BMI, health) and moderators (weather sensitivity, adjacent main roads and associated annoyance) need to be considered as indispensible part of the observed relationship.This study confirms a potential new noise effect pathway and discusses potential patho-physiological routes of actions.

View Article: PubMed Central - PubMed

Affiliation: Division of Social Medicine, Medical University Innsbruck, Sonnenburgstrasse 16, A-6020 Innsbruck, Austria. Peter.Lercher@i-med.ac.at.

ABSTRACT
Up to now, traffic noise effect studies focused on hypertension as health outcome. Hypotension has not been considered as a potential health outcome although in experiments some people also responded to noise with decreases of blood pressure. Currently, the characteristics of these persons are not known and whether this down regulation of blood pressure is an experimental artifact, selection, or can also be observed in population studies is unanswered. In a cross-sectional replication study, we randomly sampled participants (age 20-75, N = 807) from circular areas (radius = 500 m) around 31 noise measurement sites from four noise exposure strata (35-44, 45-54, 55-64, >64 Leq, dBA). Repeated blood pressure measurements were available for a smaller sample (N = 570). Standardized information on socio-demographics, housing, life style and health was obtained by door to door visits including anthropometric measurements. Noise and air pollution exposure was assigned by GIS based on both calculation and measurements. Reported hypotension or hypotension medication past year was the main outcome studied. Exposure-effect relationships were modeled with multiple non-linear logistic regression techniques using separate noise estimations for total, highway and rail exposure. Reported hypotension was significantly associated with rail and total noise exposure and strongly modified by weather sensitivity. Reported hypotension medication showed associations of similar size with rail and total noise exposure without effect modification by weather sensitivity. The size of the associations in the smaller sample with BMI as additional covariate was similar. Other important cofactors (sex, age, BMI, health) and moderators (weather sensitivity, adjacent main roads and associated annoyance) need to be considered as indispensible part of the observed relationship. This study confirms a potential new noise effect pathway and discusses potential patho-physiological routes of actions.

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Related in: MedlinePlus

Predicted probability of reported hypotension past year with total sound level exposure by (a) sex and (b) weather sensitivity. Models are adjusted for age, education, anti-hypertensive treatment, family history of hypertension, health status, sleep score, distance to main road, annoyance by local roads, region and the IA-terms age × sex, weather sensitivity × health, weather sensitivity × sound exposure, distance × sound exposure and annoyance × sound exposure.
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ijerph-11-08661-f001: Predicted probability of reported hypotension past year with total sound level exposure by (a) sex and (b) weather sensitivity. Models are adjusted for age, education, anti-hypertensive treatment, family history of hypertension, health status, sleep score, distance to main road, annoyance by local roads, region and the IA-terms age × sex, weather sensitivity × health, weather sensitivity × sound exposure, distance × sound exposure and annoyance × sound exposure.

Mentions: Due to the significant interaction of the sound level with weather sensitivity and annoyance we cannot attribute the effect observed to the sound level alone. Another significant interaction between weather sensitivity and health status is observed and indicates that both health status and weather sensitivity are critical contributors in this model. Figure 1 show the overall exposure response information by sex and weather sensitivity. The interaction between sound level and weather sensitivity is statistically significant.


Hypotension and environmental noise: a replication study.

Lercher P, Widmann U, Thudium J - Int J Environ Res Public Health (2014)

Predicted probability of reported hypotension past year with total sound level exposure by (a) sex and (b) weather sensitivity. Models are adjusted for age, education, anti-hypertensive treatment, family history of hypertension, health status, sleep score, distance to main road, annoyance by local roads, region and the IA-terms age × sex, weather sensitivity × health, weather sensitivity × sound exposure, distance × sound exposure and annoyance × sound exposure.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4198985&req=5

ijerph-11-08661-f001: Predicted probability of reported hypotension past year with total sound level exposure by (a) sex and (b) weather sensitivity. Models are adjusted for age, education, anti-hypertensive treatment, family history of hypertension, health status, sleep score, distance to main road, annoyance by local roads, region and the IA-terms age × sex, weather sensitivity × health, weather sensitivity × sound exposure, distance × sound exposure and annoyance × sound exposure.
Mentions: Due to the significant interaction of the sound level with weather sensitivity and annoyance we cannot attribute the effect observed to the sound level alone. Another significant interaction between weather sensitivity and health status is observed and indicates that both health status and weather sensitivity are critical contributors in this model. Figure 1 show the overall exposure response information by sex and weather sensitivity. The interaction between sound level and weather sensitivity is statistically significant.

Bottom Line: Hypotension has not been considered as a potential health outcome although in experiments some people also responded to noise with decreases of blood pressure.Other important cofactors (sex, age, BMI, health) and moderators (weather sensitivity, adjacent main roads and associated annoyance) need to be considered as indispensible part of the observed relationship.This study confirms a potential new noise effect pathway and discusses potential patho-physiological routes of actions.

View Article: PubMed Central - PubMed

Affiliation: Division of Social Medicine, Medical University Innsbruck, Sonnenburgstrasse 16, A-6020 Innsbruck, Austria. Peter.Lercher@i-med.ac.at.

ABSTRACT
Up to now, traffic noise effect studies focused on hypertension as health outcome. Hypotension has not been considered as a potential health outcome although in experiments some people also responded to noise with decreases of blood pressure. Currently, the characteristics of these persons are not known and whether this down regulation of blood pressure is an experimental artifact, selection, or can also be observed in population studies is unanswered. In a cross-sectional replication study, we randomly sampled participants (age 20-75, N = 807) from circular areas (radius = 500 m) around 31 noise measurement sites from four noise exposure strata (35-44, 45-54, 55-64, >64 Leq, dBA). Repeated blood pressure measurements were available for a smaller sample (N = 570). Standardized information on socio-demographics, housing, life style and health was obtained by door to door visits including anthropometric measurements. Noise and air pollution exposure was assigned by GIS based on both calculation and measurements. Reported hypotension or hypotension medication past year was the main outcome studied. Exposure-effect relationships were modeled with multiple non-linear logistic regression techniques using separate noise estimations for total, highway and rail exposure. Reported hypotension was significantly associated with rail and total noise exposure and strongly modified by weather sensitivity. Reported hypotension medication showed associations of similar size with rail and total noise exposure without effect modification by weather sensitivity. The size of the associations in the smaller sample with BMI as additional covariate was similar. Other important cofactors (sex, age, BMI, health) and moderators (weather sensitivity, adjacent main roads and associated annoyance) need to be considered as indispensible part of the observed relationship. This study confirms a potential new noise effect pathway and discusses potential patho-physiological routes of actions.

Show MeSH
Related in: MedlinePlus