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Design and Rationale of Gulf locals with Acute Coronary Syndrome Events (Gulf Coast) Registry.

Zubaid M, Thani KB, Rashed W, Alsheikh-Ali A, Alrawahi N, Ridha M, Akbar M, Alenezi F, Alhamdan R, Almahmeed W, Ouda H, Al-Mulla A, Baslaib F, Shehab A, Alnuaimi A, Amin H, Krumholz HM, Gulf COAST investigato - Open Cardiovasc Med J (2014)

Bottom Line: Data entered online included patient demographics, cardiovascular risk profiles, past medical history, physical findings on admission, in-hospital diagnostic tests and therapeutic management, as well as one year outcomes. 3188 patients were recruited.Patients with ACS in our region are young with very high risk profile.The Gulf COAST registry is an example of successful regional collaboration and will provide information on contemporary management of ACS in the region.

View Article: PubMed Central - PubMed

Affiliation: Department of Medicine, Faculty of Medicine, Kuwait University, Kuwait.

ABSTRACT

Objectives: To describe the risk profile, management and one-year outcomes of patients hospitalized with acute coronary syndrome (ACS) in the Gulf region of the Middle East.

Subjects and methods: The Gulf locals with acute coronary syndrome events (Gulf COAST) registry is a prospective, multinational, longitudinal, observational, cohort-based registry of consecutive citizens, from the Gulf region of the Middle East, admitted from January 2012 to January 2013 to 29 hospitals with a diagnosis of ACS. Data entered online included patient demographics, cardiovascular risk profiles, past medical history, physical findings on admission, in-hospital diagnostic tests and therapeutic management, as well as one year outcomes.

Results: 3188 patients were recruited. The mean age was 60.4 ± 12.6years (range: 22-112), 2104 (66%) were males and 1084 (34%) females. The discharge diagnosis was ST-segment elevation myocardial infarction (STEMI) in 741 (23.2%), new-onset left bundle branch block myocardial infarction (LBBBMI) in 30 (0.9%), non-ST-segment elevation myocardial infarction (NSTEMI) in 1486 (46.6%) and unstable angina in 931 (29.2%). At hospital presentation, 2105 (66%), 1779 (55.8%), 1703 (53.4%) and 740 (23.2%) had history of hypertension, dyslipidemia, diabetes mellitus and active smoking, respectively.

Conclusion: Patients with ACS in our region are young with very high risk profile. The Gulf COAST registry is an example of successful regional collaboration and will provide information on contemporary management of ACS in the region.

No MeSH data available.


Related in: MedlinePlus

Sample size calculation.
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Figure 1: Sample size calculation.

Mentions: As shown in Fig. (1), a sample size of 4,000 will provide adequate precision in estimating annual mortality over a reasonably wide range of event rates, and is logistically feasible given our prior experience [5]. We also considered the precision of all-cause mortality estimates for the following subgroups: ST-segment elevation myocardial infarction (STEMI), women, and patients younger than 50 years. Based on observations from Gulf RACE [5]. We estimate that 20% of citizens with ACS will have STEMI, 40% will be women, and 25% will be younger than 50 years. Therefore, for a total sample size of 4,000 patients with ACS, we expect 800 patients with STEMI, 1600 women, and 1000 patients younger than 50 years. These numbers will allow us adequate precision around all-cause mortality estimates for these subgroups with at least 90% confidence and, at most, 2% margin of error.


Design and Rationale of Gulf locals with Acute Coronary Syndrome Events (Gulf Coast) Registry.

Zubaid M, Thani KB, Rashed W, Alsheikh-Ali A, Alrawahi N, Ridha M, Akbar M, Alenezi F, Alhamdan R, Almahmeed W, Ouda H, Al-Mulla A, Baslaib F, Shehab A, Alnuaimi A, Amin H, Krumholz HM, Gulf COAST investigato - Open Cardiovasc Med J (2014)

Sample size calculation.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4197526&req=5

Figure 1: Sample size calculation.
Mentions: As shown in Fig. (1), a sample size of 4,000 will provide adequate precision in estimating annual mortality over a reasonably wide range of event rates, and is logistically feasible given our prior experience [5]. We also considered the precision of all-cause mortality estimates for the following subgroups: ST-segment elevation myocardial infarction (STEMI), women, and patients younger than 50 years. Based on observations from Gulf RACE [5]. We estimate that 20% of citizens with ACS will have STEMI, 40% will be women, and 25% will be younger than 50 years. Therefore, for a total sample size of 4,000 patients with ACS, we expect 800 patients with STEMI, 1600 women, and 1000 patients younger than 50 years. These numbers will allow us adequate precision around all-cause mortality estimates for these subgroups with at least 90% confidence and, at most, 2% margin of error.

Bottom Line: Data entered online included patient demographics, cardiovascular risk profiles, past medical history, physical findings on admission, in-hospital diagnostic tests and therapeutic management, as well as one year outcomes. 3188 patients were recruited.Patients with ACS in our region are young with very high risk profile.The Gulf COAST registry is an example of successful regional collaboration and will provide information on contemporary management of ACS in the region.

View Article: PubMed Central - PubMed

Affiliation: Department of Medicine, Faculty of Medicine, Kuwait University, Kuwait.

ABSTRACT

Objectives: To describe the risk profile, management and one-year outcomes of patients hospitalized with acute coronary syndrome (ACS) in the Gulf region of the Middle East.

Subjects and methods: The Gulf locals with acute coronary syndrome events (Gulf COAST) registry is a prospective, multinational, longitudinal, observational, cohort-based registry of consecutive citizens, from the Gulf region of the Middle East, admitted from January 2012 to January 2013 to 29 hospitals with a diagnosis of ACS. Data entered online included patient demographics, cardiovascular risk profiles, past medical history, physical findings on admission, in-hospital diagnostic tests and therapeutic management, as well as one year outcomes.

Results: 3188 patients were recruited. The mean age was 60.4 ± 12.6years (range: 22-112), 2104 (66%) were males and 1084 (34%) females. The discharge diagnosis was ST-segment elevation myocardial infarction (STEMI) in 741 (23.2%), new-onset left bundle branch block myocardial infarction (LBBBMI) in 30 (0.9%), non-ST-segment elevation myocardial infarction (NSTEMI) in 1486 (46.6%) and unstable angina in 931 (29.2%). At hospital presentation, 2105 (66%), 1779 (55.8%), 1703 (53.4%) and 740 (23.2%) had history of hypertension, dyslipidemia, diabetes mellitus and active smoking, respectively.

Conclusion: Patients with ACS in our region are young with very high risk profile. The Gulf COAST registry is an example of successful regional collaboration and will provide information on contemporary management of ACS in the region.

No MeSH data available.


Related in: MedlinePlus