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Cutaneous leiomyosarcoma - Case report.

Ciurea ME, Georgescu CV, Radu CC, Georgescu CC, Stoica LE - J Med Life (2014)

Bottom Line: Primary tumor excision with wide oncological safety margins is considered, when suitable case, the most appropriate method.Other therapeutic methods, such as radio- or chemotherapy are described as without significant benefits.We recommend long-term follow-up of patients to capture a subsequent malignant disease progression.

View Article: PubMed Central - PubMed

Affiliation: Department of Plastic and Reconstructive Surgery, Craiova University of Medicine and Pharmacy.

ABSTRACT
Cutaneous leiomyosarcoma (CLM) is a very rare smooth muscle tumor arising from the dermis or subcutaneous tissue in the skin. Superficial leiomyosarcoma originates in the superficial dermis or subcutaneous tissue and represents about 3% of the soft tissue sarcomas. CLM presents in persons of all ages but with a peak between 60-70 years old. It may also occur anywhere on the body; the existing cases reported it on the face and trunk. The clinic of leiomyosarcoma consists in a firm dermal nodule, which can be painful, pruritic or paresthestic. The tumor is of 1-3 cm in diameter and can often be seen as a solitary formation. We report one case of a cutaneous leiomyosarcoma arising in the chest region of a 79- year-old male. Leiomyosarcoma is a rare entity whose clinical presentation may appear nonspecific, making diagnosis difficult. Primary tumor excision with wide oncological safety margins is considered, when suitable case, the most appropriate method. Other therapeutic methods, such as radio- or chemotherapy are described as without significant benefits. Despite the claims of radical surgical treatment, due to recurrence rates, the prognosis remains poor. We recommend long-term follow-up of patients to capture a subsequent malignant disease progression.

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Related in: MedlinePlus

Immunohistochemical stain for vimentin: diffuse positive in tumor cells; hypodermis invasion (x 40)
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Figure 4: Immunohistochemical stain for vimentin: diffuse positive in tumor cells; hypodermis invasion (x 40)

Mentions: The surgical margins were free of disease. On a detailed immunohistochemical analysis, the tumor cells were intensely positive for smooth muscle actin (SMA), moderately positive for vimentin (Fig. 34) and negative for CD34 that was positive only in the vessels endothelium (Fig. 5).


Cutaneous leiomyosarcoma - Case report.

Ciurea ME, Georgescu CV, Radu CC, Georgescu CC, Stoica LE - J Med Life (2014)

Immunohistochemical stain for vimentin: diffuse positive in tumor cells; hypodermis invasion (x 40)
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4197510&req=5

Figure 4: Immunohistochemical stain for vimentin: diffuse positive in tumor cells; hypodermis invasion (x 40)
Mentions: The surgical margins were free of disease. On a detailed immunohistochemical analysis, the tumor cells were intensely positive for smooth muscle actin (SMA), moderately positive for vimentin (Fig. 34) and negative for CD34 that was positive only in the vessels endothelium (Fig. 5).

Bottom Line: Primary tumor excision with wide oncological safety margins is considered, when suitable case, the most appropriate method.Other therapeutic methods, such as radio- or chemotherapy are described as without significant benefits.We recommend long-term follow-up of patients to capture a subsequent malignant disease progression.

View Article: PubMed Central - PubMed

Affiliation: Department of Plastic and Reconstructive Surgery, Craiova University of Medicine and Pharmacy.

ABSTRACT
Cutaneous leiomyosarcoma (CLM) is a very rare smooth muscle tumor arising from the dermis or subcutaneous tissue in the skin. Superficial leiomyosarcoma originates in the superficial dermis or subcutaneous tissue and represents about 3% of the soft tissue sarcomas. CLM presents in persons of all ages but with a peak between 60-70 years old. It may also occur anywhere on the body; the existing cases reported it on the face and trunk. The clinic of leiomyosarcoma consists in a firm dermal nodule, which can be painful, pruritic or paresthestic. The tumor is of 1-3 cm in diameter and can often be seen as a solitary formation. We report one case of a cutaneous leiomyosarcoma arising in the chest region of a 79- year-old male. Leiomyosarcoma is a rare entity whose clinical presentation may appear nonspecific, making diagnosis difficult. Primary tumor excision with wide oncological safety margins is considered, when suitable case, the most appropriate method. Other therapeutic methods, such as radio- or chemotherapy are described as without significant benefits. Despite the claims of radical surgical treatment, due to recurrence rates, the prognosis remains poor. We recommend long-term follow-up of patients to capture a subsequent malignant disease progression.

Show MeSH
Related in: MedlinePlus