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Cutaneous leiomyosarcoma - Case report.

Ciurea ME, Georgescu CV, Radu CC, Georgescu CC, Stoica LE - J Med Life (2014)

Bottom Line: Primary tumor excision with wide oncological safety margins is considered, when suitable case, the most appropriate method.Other therapeutic methods, such as radio- or chemotherapy are described as without significant benefits.We recommend long-term follow-up of patients to capture a subsequent malignant disease progression.

View Article: PubMed Central - PubMed

Affiliation: Department of Plastic and Reconstructive Surgery, Craiova University of Medicine and Pharmacy.

ABSTRACT
Cutaneous leiomyosarcoma (CLM) is a very rare smooth muscle tumor arising from the dermis or subcutaneous tissue in the skin. Superficial leiomyosarcoma originates in the superficial dermis or subcutaneous tissue and represents about 3% of the soft tissue sarcomas. CLM presents in persons of all ages but with a peak between 60-70 years old. It may also occur anywhere on the body; the existing cases reported it on the face and trunk. The clinic of leiomyosarcoma consists in a firm dermal nodule, which can be painful, pruritic or paresthestic. The tumor is of 1-3 cm in diameter and can often be seen as a solitary formation. We report one case of a cutaneous leiomyosarcoma arising in the chest region of a 79- year-old male. Leiomyosarcoma is a rare entity whose clinical presentation may appear nonspecific, making diagnosis difficult. Primary tumor excision with wide oncological safety margins is considered, when suitable case, the most appropriate method. Other therapeutic methods, such as radio- or chemotherapy are described as without significant benefits. Despite the claims of radical surgical treatment, due to recurrence rates, the prognosis remains poor. We recommend long-term follow-up of patients to capture a subsequent malignant disease progression.

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Related in: MedlinePlus

Histopathological features of cutaneous leiomyosarcoma: hypodermis invasion, elongated cells arranged in intersecting bundles, pleomorphic nuclei (HE stain x 40)
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Figure 2: Histopathological features of cutaneous leiomyosarcoma: hypodermis invasion, elongated cells arranged in intersecting bundles, pleomorphic nuclei (HE stain x 40)

Mentions: Histopathological examination revealed a tumor consisting of elongated malignant cells characterized by nuclear polymorphism combined with atypical mitoses. It also revealed the tumor extension in the hypodermis, showing a fasciculated growth pattern of spindle cells with hyperchromatic and pleomorphic nuclei and eosinophilic cytoplasm (Fig. 2).


Cutaneous leiomyosarcoma - Case report.

Ciurea ME, Georgescu CV, Radu CC, Georgescu CC, Stoica LE - J Med Life (2014)

Histopathological features of cutaneous leiomyosarcoma: hypodermis invasion, elongated cells arranged in intersecting bundles, pleomorphic nuclei (HE stain x 40)
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4197510&req=5

Figure 2: Histopathological features of cutaneous leiomyosarcoma: hypodermis invasion, elongated cells arranged in intersecting bundles, pleomorphic nuclei (HE stain x 40)
Mentions: Histopathological examination revealed a tumor consisting of elongated malignant cells characterized by nuclear polymorphism combined with atypical mitoses. It also revealed the tumor extension in the hypodermis, showing a fasciculated growth pattern of spindle cells with hyperchromatic and pleomorphic nuclei and eosinophilic cytoplasm (Fig. 2).

Bottom Line: Primary tumor excision with wide oncological safety margins is considered, when suitable case, the most appropriate method.Other therapeutic methods, such as radio- or chemotherapy are described as without significant benefits.We recommend long-term follow-up of patients to capture a subsequent malignant disease progression.

View Article: PubMed Central - PubMed

Affiliation: Department of Plastic and Reconstructive Surgery, Craiova University of Medicine and Pharmacy.

ABSTRACT
Cutaneous leiomyosarcoma (CLM) is a very rare smooth muscle tumor arising from the dermis or subcutaneous tissue in the skin. Superficial leiomyosarcoma originates in the superficial dermis or subcutaneous tissue and represents about 3% of the soft tissue sarcomas. CLM presents in persons of all ages but with a peak between 60-70 years old. It may also occur anywhere on the body; the existing cases reported it on the face and trunk. The clinic of leiomyosarcoma consists in a firm dermal nodule, which can be painful, pruritic or paresthestic. The tumor is of 1-3 cm in diameter and can often be seen as a solitary formation. We report one case of a cutaneous leiomyosarcoma arising in the chest region of a 79- year-old male. Leiomyosarcoma is a rare entity whose clinical presentation may appear nonspecific, making diagnosis difficult. Primary tumor excision with wide oncological safety margins is considered, when suitable case, the most appropriate method. Other therapeutic methods, such as radio- or chemotherapy are described as without significant benefits. Despite the claims of radical surgical treatment, due to recurrence rates, the prognosis remains poor. We recommend long-term follow-up of patients to capture a subsequent malignant disease progression.

Show MeSH
Related in: MedlinePlus