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Breast metastasis from lung cancer: a report of two cases and literature review.

Wang L, Wang SL, Shen HH, Niu FT, Niu Y - Cancer Biol Med (2014)

Bottom Line: A poorly defined mass was noted in the lower inner quadrant of the right breast.Mammography results also revealed breast cancer.An accurate differentiation of metastasis to the breast from primary breast cancer is very important because the treatment and prognosis of the two differ significantly.

View Article: PubMed Central - PubMed

Affiliation: Department of Breast Cancer Pathology and Research Laboratory; Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Ministry of Education; Key Laboratory of Cancer Prevention and Therapy, Tianjin; Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center of Cancer, Tianjin 30060, China.

ABSTRACT
Breast metastasis from extra-mammary malignancy is rare. An incidence of 0.4% to 1.3% has been reported in literature. The primary malignancies that most commonly metastasize to the breast are leukemia, lymphoma, and malignant melanoma. In this report, two cases of pulmonary metastasis to the breast were presented. A 40-year-old female manifested a right breast mass of 2-month duration. After physical examination was performed, a poorly defined mass was noted in the upper outer quadrant of the right breast. Another 49-year-old female manifested right breast mass of 5-day duration. A poorly defined mass was noted in the lower inner quadrant of the right breast. Mammography results also revealed breast cancer. The patients underwent local excision. After histological and immunohistochemical analyses were conducted, a primary lung carcinoma that metastasized to the breast was diagnosed. An accurate differentiation of metastasis to the breast from primary breast cancer is very important because the treatment and prognosis of the two differ significantly.

No MeSH data available.


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Differential diagnosis of case 1.
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f2: Differential diagnosis of case 1.

Mentions: Hematoxylin and eosin (H&E)-stained paraffin sections of the breast specimen revealed spindle cell carcinoma. These poorly differentiated tumors were composed of large crowded clusters of cells with moderate to abundant cytoplasm; these tumors also displayed an infiltrative growth pattern. Furthermore, these tumors consisted of densely and solid nests of spindle cells separated by delicate fibrovascular stroma. In some tumors, nuclear streaming occurred. Our differential diagnosis included primary breast carcinoma and metastatic carcinoma from the lungs. The tumor cells demonstrated immunoreactivity for CK7, CK8, thyroid transcription factor-1 (TTF1), neuron-specific enolase (NSE), Syn, CgA, and SOX-2. The neoplastic cells lacked expressions of smooth muscle actin (SMA), p63, calponin, p40, gross cystic disease fluid protein-15 (GCDFP-15), mammaglobin (MG), CA15-3, estrogen receptor (ER), progesterone receptor (PR), c-erb-2, CK 5/6 and CD56. The expressions of Ki67 and p53 showed strong nuclear staining in 50% and 85% of the tumor cells, respectively. No evidence of in situ carcinoma was observed (Figure 1). Spindle cell neuroendocrine carcinoma metastasized from the lungs was diagnosed based on histological and immunohistochemical staining patterns (Figure 2); this result is consistent with contralateral breast tumor diagnosis.


Breast metastasis from lung cancer: a report of two cases and literature review.

Wang L, Wang SL, Shen HH, Niu FT, Niu Y - Cancer Biol Med (2014)

Differential diagnosis of case 1.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4197421&req=5

f2: Differential diagnosis of case 1.
Mentions: Hematoxylin and eosin (H&E)-stained paraffin sections of the breast specimen revealed spindle cell carcinoma. These poorly differentiated tumors were composed of large crowded clusters of cells with moderate to abundant cytoplasm; these tumors also displayed an infiltrative growth pattern. Furthermore, these tumors consisted of densely and solid nests of spindle cells separated by delicate fibrovascular stroma. In some tumors, nuclear streaming occurred. Our differential diagnosis included primary breast carcinoma and metastatic carcinoma from the lungs. The tumor cells demonstrated immunoreactivity for CK7, CK8, thyroid transcription factor-1 (TTF1), neuron-specific enolase (NSE), Syn, CgA, and SOX-2. The neoplastic cells lacked expressions of smooth muscle actin (SMA), p63, calponin, p40, gross cystic disease fluid protein-15 (GCDFP-15), mammaglobin (MG), CA15-3, estrogen receptor (ER), progesterone receptor (PR), c-erb-2, CK 5/6 and CD56. The expressions of Ki67 and p53 showed strong nuclear staining in 50% and 85% of the tumor cells, respectively. No evidence of in situ carcinoma was observed (Figure 1). Spindle cell neuroendocrine carcinoma metastasized from the lungs was diagnosed based on histological and immunohistochemical staining patterns (Figure 2); this result is consistent with contralateral breast tumor diagnosis.

Bottom Line: A poorly defined mass was noted in the lower inner quadrant of the right breast.Mammography results also revealed breast cancer.An accurate differentiation of metastasis to the breast from primary breast cancer is very important because the treatment and prognosis of the two differ significantly.

View Article: PubMed Central - PubMed

Affiliation: Department of Breast Cancer Pathology and Research Laboratory; Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Ministry of Education; Key Laboratory of Cancer Prevention and Therapy, Tianjin; Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center of Cancer, Tianjin 30060, China.

ABSTRACT
Breast metastasis from extra-mammary malignancy is rare. An incidence of 0.4% to 1.3% has been reported in literature. The primary malignancies that most commonly metastasize to the breast are leukemia, lymphoma, and malignant melanoma. In this report, two cases of pulmonary metastasis to the breast were presented. A 40-year-old female manifested a right breast mass of 2-month duration. After physical examination was performed, a poorly defined mass was noted in the upper outer quadrant of the right breast. Another 49-year-old female manifested right breast mass of 5-day duration. A poorly defined mass was noted in the lower inner quadrant of the right breast. Mammography results also revealed breast cancer. The patients underwent local excision. After histological and immunohistochemical analyses were conducted, a primary lung carcinoma that metastasized to the breast was diagnosed. An accurate differentiation of metastasis to the breast from primary breast cancer is very important because the treatment and prognosis of the two differ significantly.

No MeSH data available.


Related in: MedlinePlus