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Effect of caffeic acid derivatives on polychlorinated biphenyls induced hepatotoxicity in male mice.

Li R, Cao S, Dai J, Wang L, Li L, Wang Y, Yin W, Ye Y - J Biomed Res (2014)

Bottom Line: Chronic exposure to coplanar polychlorinated biphenyls (PCBs), a potent inducer of toxic reactive oxygen species (ROS), in the environment and food can cause liver diseases.We found that PCB169 decreased the growth rate and reduced the levels of superoxide dismutase (SOD), glutathione (GSH) and GSH peroxidase (GPx).In conclusion, PCB169 induced hepatotoxicity and pretreatment with CADs had synergistic protective effects on liver damage.

View Article: PubMed Central - PubMed

Affiliation: The First People's Hospital of Suqian, Suqian, Jiangsu 223800, Chian.

ABSTRACT
Chronic exposure to coplanar polychlorinated biphenyls (PCBs), a potent inducer of toxic reactive oxygen species (ROS), in the environment and food can cause liver diseases. It remains unknown whether caffeic acid derivatives (CADs) exerted protective effect on PCB-induced hepatotoxicity. We sought to evaluate the activities of 3 CADs on PCB169-induced oxidative stress and DNA damage in the liver. Male ICR mice were administered with 1 μmol/mL PCB169 at 5 mL/kg body weight for 2 weeks. The mice were given CADs by gastric gavage for 3 weeks. We found that PCB169 decreased the growth rate and reduced the levels of superoxide dismutase (SOD), glutathione (GSH) and GSH peroxidase (GPx). It increased the liver weight, malondialdehyde (MDA) and 8-hydroxy-2'-deoxyguanosine (8-OHdG) levels and CYP1A1 activity in the liver tissues and plasma of mice (P<0.05). Pretreatment of mice with CADs restored the above parameters to normal levels. There was a synergistic protective effect between CADs in preventing MDA and 8-OHdG formation and inducing CYP1A1 and phase II metabolism enzyme (SOD, GPx) activities (P<0.05). In conclusion, PCB169 induced hepatotoxicity and pretreatment with CADs had synergistic protective effects on liver damage.

No MeSH data available.


Related in: MedlinePlus

Effect of CADs on SOD activities in the PCB169-treated mice.One-way ANOVA was performed to examine statistically significant differences (P<0.05) between each different combination of CADs level and the corn oil treatment (indicated by “*” if significant, “#” indicates significant difference of physiological saline treatment. P<0.05). CAD: caffeic acid derivatives.
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f01: Effect of CADs on SOD activities in the PCB169-treated mice.One-way ANOVA was performed to examine statistically significant differences (P<0.05) between each different combination of CADs level and the corn oil treatment (indicated by “*” if significant, “#” indicates significant difference of physiological saline treatment. P<0.05). CAD: caffeic acid derivatives.

Mentions: SOD activity was decreased significantly with increasing doses of PCB169 (Fig. 1). However, SOD activity was increased significantly (P<0.05) by CADs compared to that of mice treated with normal saline (Group 1) or corn oil (Group 2). ChA alone and the combination of 2 CADs attenuated decreases in SOD activities in all groups.


Effect of caffeic acid derivatives on polychlorinated biphenyls induced hepatotoxicity in male mice.

Li R, Cao S, Dai J, Wang L, Li L, Wang Y, Yin W, Ye Y - J Biomed Res (2014)

Effect of CADs on SOD activities in the PCB169-treated mice.One-way ANOVA was performed to examine statistically significant differences (P<0.05) between each different combination of CADs level and the corn oil treatment (indicated by “*” if significant, “#” indicates significant difference of physiological saline treatment. P<0.05). CAD: caffeic acid derivatives.
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Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4197394&req=5

f01: Effect of CADs on SOD activities in the PCB169-treated mice.One-way ANOVA was performed to examine statistically significant differences (P<0.05) between each different combination of CADs level and the corn oil treatment (indicated by “*” if significant, “#” indicates significant difference of physiological saline treatment. P<0.05). CAD: caffeic acid derivatives.
Mentions: SOD activity was decreased significantly with increasing doses of PCB169 (Fig. 1). However, SOD activity was increased significantly (P<0.05) by CADs compared to that of mice treated with normal saline (Group 1) or corn oil (Group 2). ChA alone and the combination of 2 CADs attenuated decreases in SOD activities in all groups.

Bottom Line: Chronic exposure to coplanar polychlorinated biphenyls (PCBs), a potent inducer of toxic reactive oxygen species (ROS), in the environment and food can cause liver diseases.We found that PCB169 decreased the growth rate and reduced the levels of superoxide dismutase (SOD), glutathione (GSH) and GSH peroxidase (GPx).In conclusion, PCB169 induced hepatotoxicity and pretreatment with CADs had synergistic protective effects on liver damage.

View Article: PubMed Central - PubMed

Affiliation: The First People's Hospital of Suqian, Suqian, Jiangsu 223800, Chian.

ABSTRACT
Chronic exposure to coplanar polychlorinated biphenyls (PCBs), a potent inducer of toxic reactive oxygen species (ROS), in the environment and food can cause liver diseases. It remains unknown whether caffeic acid derivatives (CADs) exerted protective effect on PCB-induced hepatotoxicity. We sought to evaluate the activities of 3 CADs on PCB169-induced oxidative stress and DNA damage in the liver. Male ICR mice were administered with 1 μmol/mL PCB169 at 5 mL/kg body weight for 2 weeks. The mice were given CADs by gastric gavage for 3 weeks. We found that PCB169 decreased the growth rate and reduced the levels of superoxide dismutase (SOD), glutathione (GSH) and GSH peroxidase (GPx). It increased the liver weight, malondialdehyde (MDA) and 8-hydroxy-2'-deoxyguanosine (8-OHdG) levels and CYP1A1 activity in the liver tissues and plasma of mice (P<0.05). Pretreatment of mice with CADs restored the above parameters to normal levels. There was a synergistic protective effect between CADs in preventing MDA and 8-OHdG formation and inducing CYP1A1 and phase II metabolism enzyme (SOD, GPx) activities (P<0.05). In conclusion, PCB169 induced hepatotoxicity and pretreatment with CADs had synergistic protective effects on liver damage.

No MeSH data available.


Related in: MedlinePlus