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AEG-1 expression correlates with CD133 and PPP6c levels in human glioma tissues.

Guo J, Chen X, Xi R, Chang Y, Zhang X, Zhang X - J Biomed Res (2014)

Bottom Line: Astrocyte elevated gene-1 (AEG-1) is associated with tumor genesis and progression in a variety of human cancers.No correlation was found between AEG-1 expression and other clinicopathologic parameters (P>0.05).Our findings indicate that AEG-1 is positively correlated with CD133 and AEG-1 expression.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiotherapy, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, China.

ABSTRACT
Astrocyte elevated gene-1 (AEG-1) is associated with tumor genesis and progression in a variety of human cancers. This study aimed to explore the significance of AEG-1 in glioma and investigate whether it correlated with radioresistance of glioma cells. Immunohistochemical staining showed that the intensity of AEG-1, CD133 and PPP6c protein expression in glioma tissues increased significantly, mainly in the cytoplasm. The expression rate of AEG-1, CD133 and PPP6c were 85.9% (67/78), 60.3% (47/78) and 65.8% (51/78), respectively. AEG-1 expression was correlated with age (r = 0.227, P = 0.045), clinical stage (r = 0.491, P<0.001) and clinical grade (r = 0.450, P<0.001). No correlation was found between AEG-1 expression and other clinicopathologic parameters (P>0.05). The expression of AEG-1 was positively correlated with the expression of CD133 (r = 0.240, P  =  0.035) and PPP6c (r =  0.250, P  =  0.027). In addition, retrieved data on TCGA implied co-occurrence of genomic alterations of AEG-1 and PPP6c in glioblastoma. Our findings indicate that AEG-1 is positively correlated with CD133 and AEG-1 expression. It may play an important role in the progression of glioma and may serve as potential novel marker of chemoresistance and radioresistance.

No MeSH data available.


Related in: MedlinePlus

The data of AEG-1 and PPP6c expression in TCGA.Microarray shows that AEG-1 and PPP6c gene expression in brain lower grade glioma (LGG) (Fig. 2A) and Glioblastoma Multiforme (GBM) (Fig. 2B) have the similar trends. Fig. 2C and 2D show an overview of genomic alterations (legend) in AEG-1 and PPP6c (rows) affecting particular individual samples (columns). Genomic alterations of AEG-1 and PPP6c in GBM are compatible.
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f02: The data of AEG-1 and PPP6c expression in TCGA.Microarray shows that AEG-1 and PPP6c gene expression in brain lower grade glioma (LGG) (Fig. 2A) and Glioblastoma Multiforme (GBM) (Fig. 2B) have the similar trends. Fig. 2C and 2D show an overview of genomic alterations (legend) in AEG-1 and PPP6c (rows) affecting particular individual samples (columns). Genomic alterations of AEG-1 and PPP6c in GBM are compatible.

Mentions: To further validate the correlation between AEG-1 and PPP6c, we retrieved more information from TCGA. According to the results of one of the earliest reports, the data of glioma in the TCGA and the tools net the cBio portal, has been widely recognized. There was a similar trend of AEG-1 and PPP6c mRNA expression in GBM (Fig. 2A and 2B). Fig. 2C and 2D showed that alterations of AEG-1 and PPP6c in GBM tend to be compatible. Statistical tests also pointed out that the tendency toward co-occurrence of AEG-1 and PPP6c in GBM (P < 0.001). However, similar trend was not found in LGG (Table 4).


AEG-1 expression correlates with CD133 and PPP6c levels in human glioma tissues.

Guo J, Chen X, Xi R, Chang Y, Zhang X, Zhang X - J Biomed Res (2014)

The data of AEG-1 and PPP6c expression in TCGA.Microarray shows that AEG-1 and PPP6c gene expression in brain lower grade glioma (LGG) (Fig. 2A) and Glioblastoma Multiforme (GBM) (Fig. 2B) have the similar trends. Fig. 2C and 2D show an overview of genomic alterations (legend) in AEG-1 and PPP6c (rows) affecting particular individual samples (columns). Genomic alterations of AEG-1 and PPP6c in GBM are compatible.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4197390&req=5

f02: The data of AEG-1 and PPP6c expression in TCGA.Microarray shows that AEG-1 and PPP6c gene expression in brain lower grade glioma (LGG) (Fig. 2A) and Glioblastoma Multiforme (GBM) (Fig. 2B) have the similar trends. Fig. 2C and 2D show an overview of genomic alterations (legend) in AEG-1 and PPP6c (rows) affecting particular individual samples (columns). Genomic alterations of AEG-1 and PPP6c in GBM are compatible.
Mentions: To further validate the correlation between AEG-1 and PPP6c, we retrieved more information from TCGA. According to the results of one of the earliest reports, the data of glioma in the TCGA and the tools net the cBio portal, has been widely recognized. There was a similar trend of AEG-1 and PPP6c mRNA expression in GBM (Fig. 2A and 2B). Fig. 2C and 2D showed that alterations of AEG-1 and PPP6c in GBM tend to be compatible. Statistical tests also pointed out that the tendency toward co-occurrence of AEG-1 and PPP6c in GBM (P < 0.001). However, similar trend was not found in LGG (Table 4).

Bottom Line: Astrocyte elevated gene-1 (AEG-1) is associated with tumor genesis and progression in a variety of human cancers.No correlation was found between AEG-1 expression and other clinicopathologic parameters (P>0.05).Our findings indicate that AEG-1 is positively correlated with CD133 and AEG-1 expression.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiotherapy, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, China.

ABSTRACT
Astrocyte elevated gene-1 (AEG-1) is associated with tumor genesis and progression in a variety of human cancers. This study aimed to explore the significance of AEG-1 in glioma and investigate whether it correlated with radioresistance of glioma cells. Immunohistochemical staining showed that the intensity of AEG-1, CD133 and PPP6c protein expression in glioma tissues increased significantly, mainly in the cytoplasm. The expression rate of AEG-1, CD133 and PPP6c were 85.9% (67/78), 60.3% (47/78) and 65.8% (51/78), respectively. AEG-1 expression was correlated with age (r = 0.227, P = 0.045), clinical stage (r = 0.491, P<0.001) and clinical grade (r = 0.450, P<0.001). No correlation was found between AEG-1 expression and other clinicopathologic parameters (P>0.05). The expression of AEG-1 was positively correlated with the expression of CD133 (r = 0.240, P  =  0.035) and PPP6c (r =  0.250, P  =  0.027). In addition, retrieved data on TCGA implied co-occurrence of genomic alterations of AEG-1 and PPP6c in glioblastoma. Our findings indicate that AEG-1 is positively correlated with CD133 and AEG-1 expression. It may play an important role in the progression of glioma and may serve as potential novel marker of chemoresistance and radioresistance.

No MeSH data available.


Related in: MedlinePlus