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Comparison of clinical outcomes of Chinese men and women after coronary stenting for coronary artery disease: a multi-center retrospective analysis of 4,334 patients.

Shrestha R, Xu J, Xie D, Liu Z, Xu T, Ye F, Din S, Qian X, Yang S, Liu Y, Li F, Zhang A, Chen S - J Biomed Res (2013)

Bottom Line: We compared these groups with respect to the primary outcomes of MI and secondary outcomes including a composite of major adverse cardiac events (MACE) including cardiac death, MI, target lesion revascularization, target vessel revascularization (TVR), stent thrombosis (ST), definite ST and probable ST at one-year follow-up.Chinese male and female patients showed a significant difference on MACEs.However, there was no significant difference with respect to MI between these groups.

View Article: PubMed Central - PubMed

Affiliation: Department of Cardiology, Nanjing Medical University, Nanjing, Jiangsu 210029, China.

ABSTRACT
The outcome differences between Chinese male and female patients within one-year follow-up after percutaneous coronary intervention (PCI) with stent remain unclear. The present study was aimed to compare clinical outcomes in such two populations. From May 1999 to December 2009, 4,334 patients with acute myocardial infarction (MI), unstable angina, stable angina, or silent ischemia, who underwent PCI, were registered at our centers. Among these, 3,089 were men and 1,245 were women. We compared these groups with respect to the primary outcomes of MI and secondary outcomes including a composite of major adverse cardiac events (MACE) including cardiac death, MI, target lesion revascularization, target vessel revascularization (TVR), stent thrombosis (ST), definite ST and probable ST at one-year follow-up. Chinese male patients had a higher MACE rate (13% vs. 10.7%, P  =  0.039), mainly led by TVR (9.09% vs. 6.98%, P = 0.024) at one year, which was significantly different than female patients. Chinese male and female patients showed a significant difference on MACEs. However, there was no significant difference with respect to MI between these groups.

No MeSH data available.


Related in: MedlinePlus

One-year major adverse cardiac events MACE free survival functions. Kaplan-Meier free survival curves for one-year MACE between male and female patients undergoing percutaneous coronary intervention.
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f02: One-year major adverse cardiac events MACE free survival functions. Kaplan-Meier free survival curves for one-year MACE between male and female patients undergoing percutaneous coronary intervention.

Mentions: Binary regression analysis revealed that diabetes (odds ratio [OR]  =  0.22, 95% confidence interval [CI]  =  0.06–0.75, P  =  0.01) and the presence of bifurcation (OR  =  0.30, 95% CI  =  0.08–1.02, P  =  0.05) were significantly associated with the occurrence of MI at one-year. Conversely, LVEF (OR  =  0.97, 95% CI  =  0.95–0.99, P  =  0.02) and LADcto (OR  =  0.29, 95% CI  =  0.09–0.85, P  =  0.02) were significantly associated with occurrence of MACE at one-year post PCI (Fig. 2) .


Comparison of clinical outcomes of Chinese men and women after coronary stenting for coronary artery disease: a multi-center retrospective analysis of 4,334 patients.

Shrestha R, Xu J, Xie D, Liu Z, Xu T, Ye F, Din S, Qian X, Yang S, Liu Y, Li F, Zhang A, Chen S - J Biomed Res (2013)

One-year major adverse cardiac events MACE free survival functions. Kaplan-Meier free survival curves for one-year MACE between male and female patients undergoing percutaneous coronary intervention.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4197387&req=5

f02: One-year major adverse cardiac events MACE free survival functions. Kaplan-Meier free survival curves for one-year MACE between male and female patients undergoing percutaneous coronary intervention.
Mentions: Binary regression analysis revealed that diabetes (odds ratio [OR]  =  0.22, 95% confidence interval [CI]  =  0.06–0.75, P  =  0.01) and the presence of bifurcation (OR  =  0.30, 95% CI  =  0.08–1.02, P  =  0.05) were significantly associated with the occurrence of MI at one-year. Conversely, LVEF (OR  =  0.97, 95% CI  =  0.95–0.99, P  =  0.02) and LADcto (OR  =  0.29, 95% CI  =  0.09–0.85, P  =  0.02) were significantly associated with occurrence of MACE at one-year post PCI (Fig. 2) .

Bottom Line: We compared these groups with respect to the primary outcomes of MI and secondary outcomes including a composite of major adverse cardiac events (MACE) including cardiac death, MI, target lesion revascularization, target vessel revascularization (TVR), stent thrombosis (ST), definite ST and probable ST at one-year follow-up.Chinese male and female patients showed a significant difference on MACEs.However, there was no significant difference with respect to MI between these groups.

View Article: PubMed Central - PubMed

Affiliation: Department of Cardiology, Nanjing Medical University, Nanjing, Jiangsu 210029, China.

ABSTRACT
The outcome differences between Chinese male and female patients within one-year follow-up after percutaneous coronary intervention (PCI) with stent remain unclear. The present study was aimed to compare clinical outcomes in such two populations. From May 1999 to December 2009, 4,334 patients with acute myocardial infarction (MI), unstable angina, stable angina, or silent ischemia, who underwent PCI, were registered at our centers. Among these, 3,089 were men and 1,245 were women. We compared these groups with respect to the primary outcomes of MI and secondary outcomes including a composite of major adverse cardiac events (MACE) including cardiac death, MI, target lesion revascularization, target vessel revascularization (TVR), stent thrombosis (ST), definite ST and probable ST at one-year follow-up. Chinese male patients had a higher MACE rate (13% vs. 10.7%, P  =  0.039), mainly led by TVR (9.09% vs. 6.98%, P = 0.024) at one year, which was significantly different than female patients. Chinese male and female patients showed a significant difference on MACEs. However, there was no significant difference with respect to MI between these groups.

No MeSH data available.


Related in: MedlinePlus