Limits...
Accelerated partial breast irradiation with intensity-modulated radiotherapy is feasible for chinese breast cancer patients.

He Z, Wu S, Zhou J, Li F, Sun J, Lin Q, Lin H, Guan X - J Breast Cancer (2014)

Bottom Line: Of the 38 patients, six patients did not meet the planning criteria.Thirty-one patients (96.8%) had fine or excellent cosmetic outcomes, and only one patient had a poor cosmetic outcome.The radiotherapeutic toxicity is acceptable, and both the initial efficacy and cosmetic outcomes are good.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiation Oncology, Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Guangzhou, China.

ABSTRACT

Purpose: Several accelerated partial breast irradiation (APBI) techniques are being investigated in patients with early-stage breast cancer. The present study evaluated the feasibility, early toxicity, initial efficacy, and cosmetic outcomes of accelerated partial breast intensity-modulated radiotherapy (IMRT) for Chinese female patients with early-stage breast cancer after breast-conserving surgery.

Methods: A total of 38 patients met the inclusion criteria and an accelerated partial breast intensity-modulated radiotherapy (APBI-IMRT) plan was designed for each patient. The prescription dose was 34 Gy in 10 fractions, 3.4 Gy per fraction, twice a day, in intervals of more than 6 hours.

Results: Of the 38 patients, six patients did not meet the planning criteria. The remaining 32 patients received APBI-IMRT with a mean target volume conformity index of 0.67 and a dose homogeneity index of 1.06. The median follow-up time was 53 months and no local recurrence or distant metastasis was detected. The most common acute toxicities observed within 3 months after radiotherapy were erythema, breast edema, pigmentation, and pain in the irradiated location, among which 43.8%, 12.5%, 31.3%, and 28.1% were grade 1 toxicities, respectively. The most common late toxicities occurring after 3 months until the end of the follow-up period were breast edema, pigmentation, pain in the irradiated location, and subcutaneous fibrosis, among which 6.2%, 28.1%, 21.9%, and 37.5% were grade 1 toxicities, respectively. Thirty-one patients (96.8%) had fine or excellent cosmetic outcomes, and only one patient had a poor cosmetic outcome.

Conclusion: It is feasible for Chinese females to receive APBI-IMRT after breast conserving surgery. The radiotherapeutic toxicity is acceptable, and both the initial efficacy and cosmetic outcomes are good.

No MeSH data available.


Related in: MedlinePlus

Dose distribution of two patients off-protocol. (A) Case 23 with tumor located in low inner quadrant, dose of heart and ipsilateral lung is in excess of the evaluation criteria of RTOG-0319. (B) Case 24 with tumor located in upper outer quadrant, dose of uninvolved normal breast is in excess of the evaluation criteria of RTOG-0319.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4197356&req=5

Figure 2: Dose distribution of two patients off-protocol. (A) Case 23 with tumor located in low inner quadrant, dose of heart and ipsilateral lung is in excess of the evaluation criteria of RTOG-0319. (B) Case 24 with tumor located in upper outer quadrant, dose of uninvolved normal breast is in excess of the evaluation criteria of RTOG-0319.

Mentions: A total of 38 patients meeting the inclusion criteria between October 2008 and October 2011 were selected in IMRT planning. Six of the 38 patients (15.7%) were off-protocol due to planning criteria violations and were treated with WBI; the details of the dose constraints of the unsuccessful plans are shown in Table 1 and Figure 2. Therefore, 32 patients received APBI-IMRT.


Accelerated partial breast irradiation with intensity-modulated radiotherapy is feasible for chinese breast cancer patients.

He Z, Wu S, Zhou J, Li F, Sun J, Lin Q, Lin H, Guan X - J Breast Cancer (2014)

Dose distribution of two patients off-protocol. (A) Case 23 with tumor located in low inner quadrant, dose of heart and ipsilateral lung is in excess of the evaluation criteria of RTOG-0319. (B) Case 24 with tumor located in upper outer quadrant, dose of uninvolved normal breast is in excess of the evaluation criteria of RTOG-0319.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4197356&req=5

Figure 2: Dose distribution of two patients off-protocol. (A) Case 23 with tumor located in low inner quadrant, dose of heart and ipsilateral lung is in excess of the evaluation criteria of RTOG-0319. (B) Case 24 with tumor located in upper outer quadrant, dose of uninvolved normal breast is in excess of the evaluation criteria of RTOG-0319.
Mentions: A total of 38 patients meeting the inclusion criteria between October 2008 and October 2011 were selected in IMRT planning. Six of the 38 patients (15.7%) were off-protocol due to planning criteria violations and were treated with WBI; the details of the dose constraints of the unsuccessful plans are shown in Table 1 and Figure 2. Therefore, 32 patients received APBI-IMRT.

Bottom Line: Of the 38 patients, six patients did not meet the planning criteria.Thirty-one patients (96.8%) had fine or excellent cosmetic outcomes, and only one patient had a poor cosmetic outcome.The radiotherapeutic toxicity is acceptable, and both the initial efficacy and cosmetic outcomes are good.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiation Oncology, Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Guangzhou, China.

ABSTRACT

Purpose: Several accelerated partial breast irradiation (APBI) techniques are being investigated in patients with early-stage breast cancer. The present study evaluated the feasibility, early toxicity, initial efficacy, and cosmetic outcomes of accelerated partial breast intensity-modulated radiotherapy (IMRT) for Chinese female patients with early-stage breast cancer after breast-conserving surgery.

Methods: A total of 38 patients met the inclusion criteria and an accelerated partial breast intensity-modulated radiotherapy (APBI-IMRT) plan was designed for each patient. The prescription dose was 34 Gy in 10 fractions, 3.4 Gy per fraction, twice a day, in intervals of more than 6 hours.

Results: Of the 38 patients, six patients did not meet the planning criteria. The remaining 32 patients received APBI-IMRT with a mean target volume conformity index of 0.67 and a dose homogeneity index of 1.06. The median follow-up time was 53 months and no local recurrence or distant metastasis was detected. The most common acute toxicities observed within 3 months after radiotherapy were erythema, breast edema, pigmentation, and pain in the irradiated location, among which 43.8%, 12.5%, 31.3%, and 28.1% were grade 1 toxicities, respectively. The most common late toxicities occurring after 3 months until the end of the follow-up period were breast edema, pigmentation, pain in the irradiated location, and subcutaneous fibrosis, among which 6.2%, 28.1%, 21.9%, and 37.5% were grade 1 toxicities, respectively. Thirty-one patients (96.8%) had fine or excellent cosmetic outcomes, and only one patient had a poor cosmetic outcome.

Conclusion: It is feasible for Chinese females to receive APBI-IMRT after breast conserving surgery. The radiotherapeutic toxicity is acceptable, and both the initial efficacy and cosmetic outcomes are good.

No MeSH data available.


Related in: MedlinePlus