Analysis of amyotrophic lateral sclerosis as a multistep process: a population-based modelling study.
Bottom Line: The combination of all five registers gave an overall slope of 4·8 (95% CI 4·5-5·0), with similar estimates for men (4·6, 4·3-4·9) and women (5·0, 4·5-5·5).Identification of these steps could lead to preventive and therapeutic avenues.UK Medical Research Council; UK Economic and Social Research Council; Ireland Health Research Board; The Netherlands Organisation for Health Research and Development (ZonMw); the Ministry of Health and Ministry of Education, University, and Research in Italy; the Motor Neurone Disease Association of England, Wales, and Northern Ireland; and the European Commission (Seventh Framework Programme).
Affiliation: King's College London, Institute of Psychiatry, Department of Clinical Neuroscience, London, UK. Electronic address: firstname.lastname@example.org.Show MeSH
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Mentions: Figure 3 shows findings for multiple sclerosis. The absence of a straight line suggests that an alternative model, such as simultaneous multiple hits, dose-dependent exposure, or continuum of risk operates.
Affiliation: King's College London, Institute of Psychiatry, Department of Clinical Neuroscience, London, UK. Electronic address: email@example.com.