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Analysis of amyotrophic lateral sclerosis as a multistep process: a population-based modelling study.

Al-Chalabi A, Calvo A, Chio A, Colville S, Ellis CM, Hardiman O, Heverin M, Howard RS, Huisman MH, Keren N, Leigh PN, Mazzini L, Mora G, Orrell RW, Rooney J, Scott KM, Scotton WJ, Seelen M, Shaw CE, Sidle KS, Swingler R, Tsuda M, Veldink JH, Visser AE, van den Berg LH, Pearce N - Lancet Neurol (2014)

Bottom Line: The combination of all five registers gave an overall slope of 4·8 (95% CI 4·5-5·0), with similar estimates for men (4·6, 4·3-4·9) and women (5·0, 4·5-5·5).Identification of these steps could lead to preventive and therapeutic avenues.UK Medical Research Council; UK Economic and Social Research Council; Ireland Health Research Board; The Netherlands Organisation for Health Research and Development (ZonMw); the Ministry of Health and Ministry of Education, University, and Research in Italy; the Motor Neurone Disease Association of England, Wales, and Northern Ireland; and the European Commission (Seventh Framework Programme).

View Article: PubMed Central - PubMed

Affiliation: King's College London, Institute of Psychiatry, Department of Clinical Neuroscience, London, UK. Electronic address: ammar.al-chalabi@kcl.ac.uk.

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Log(incidence) vs log(age) for multiple sclerosisData from the Manitoba register.18 The line is not straight, showing that the disease process does not fit to a multistep model.
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fig3: Log(incidence) vs log(age) for multiple sclerosisData from the Manitoba register.18 The line is not straight, showing that the disease process does not fit to a multistep model.

Mentions: Figure 3 shows findings for multiple sclerosis. The absence of a straight line suggests that an alternative model, such as simultaneous multiple hits, dose-dependent exposure, or continuum of risk operates.


Analysis of amyotrophic lateral sclerosis as a multistep process: a population-based modelling study.

Al-Chalabi A, Calvo A, Chio A, Colville S, Ellis CM, Hardiman O, Heverin M, Howard RS, Huisman MH, Keren N, Leigh PN, Mazzini L, Mora G, Orrell RW, Rooney J, Scott KM, Scotton WJ, Seelen M, Shaw CE, Sidle KS, Swingler R, Tsuda M, Veldink JH, Visser AE, van den Berg LH, Pearce N - Lancet Neurol (2014)

Log(incidence) vs log(age) for multiple sclerosisData from the Manitoba register.18 The line is not straight, showing that the disease process does not fit to a multistep model.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4197338&req=5

fig3: Log(incidence) vs log(age) for multiple sclerosisData from the Manitoba register.18 The line is not straight, showing that the disease process does not fit to a multistep model.
Mentions: Figure 3 shows findings for multiple sclerosis. The absence of a straight line suggests that an alternative model, such as simultaneous multiple hits, dose-dependent exposure, or continuum of risk operates.

Bottom Line: The combination of all five registers gave an overall slope of 4·8 (95% CI 4·5-5·0), with similar estimates for men (4·6, 4·3-4·9) and women (5·0, 4·5-5·5).Identification of these steps could lead to preventive and therapeutic avenues.UK Medical Research Council; UK Economic and Social Research Council; Ireland Health Research Board; The Netherlands Organisation for Health Research and Development (ZonMw); the Ministry of Health and Ministry of Education, University, and Research in Italy; the Motor Neurone Disease Association of England, Wales, and Northern Ireland; and the European Commission (Seventh Framework Programme).

View Article: PubMed Central - PubMed

Affiliation: King's College London, Institute of Psychiatry, Department of Clinical Neuroscience, London, UK. Electronic address: ammar.al-chalabi@kcl.ac.uk.

Show MeSH
Related in: MedlinePlus