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Role of mesenchymal cells in the natural history of ovarian cancer: a review.

Touboul C, Vidal F, Pasquier J, Lis R, Rafii A - J Transl Med (2014)

Bottom Line: They play a role at different stages of the disease: survival and peritoneal infiltration at early stage, proliferation in distant sites, chemoresistance and recurrence at later stage.The dialogue between ovarian and mesenchymal stem cells induces the constitution of a pro-tumoral mesencrine niche.Understanding the dynamics of such interaction in a clinical setting might propose new therapeutic strategies.

View Article: PubMed Central - PubMed

Affiliation: Department of Obstetrics and Gynecology, Hôpital Intercommunal de Créteil, Université Paris Est, UPEC-Paris XII, 12 avenue de Verdun, 94000, Créteil, France. cyril.touboul@gmail.com.

ABSTRACT

Background: Ovarian cancer is the deadliest gynaecologic malignancy. Despite progresses in chemotherapy and ultra-radical surgeries, this locally metastatic disease presents a high rate of local recurrence advocating for the role of a peritoneal niche. For several years, it was believed that tumor initiation, progression and metastasis were merely due to the changes in the neoplastic cell population and the adjacent non-neoplastic tissues were regarded as bystanders. The importance of the tumor microenvironment and its cellular component emerged from studies on the histopathological sequence of changes at the interface between putative tumor cells and the surrounding non-neoplastic tissues during carcinogenesis.

Method: In this review we aimed to describe the pro-tumoral crosstalk between ovarian cancer and mesenchymal stem cells. A PubMed search was performed for articles published pertaining to mesenchymal stem cells and specific to ovarian cancer.

Results: Mesenchymal stem cells participate to an elaborate crosstalk through direct and paracrine interaction with ovarian cancer cells. They play a role at different stages of the disease: survival and peritoneal infiltration at early stage, proliferation in distant sites, chemoresistance and recurrence at later stage.

Conclusion: The dialogue between ovarian and mesenchymal stem cells induces the constitution of a pro-tumoral mesencrine niche. Understanding the dynamics of such interaction in a clinical setting might propose new therapeutic strategies.

No MeSH data available.


Related in: MedlinePlus

Pathological aspects of normal peritoneum and peritoneal metastasis.
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Fig6: Pathological aspects of normal peritoneum and peritoneal metastasis.

Mentions: Clinical presentation at baseline in patients with advanced stages includes ascites, peritoneal carcinomatosis and omental involvement [140] (Figure 4). The peritoneum is a complex organ constituting the microenvironment of ovarian cancer metastatic nodules (Figure 5). It is composed of a continuous mesothelial cell layer covering all abdominal organs except ovaries. The peritoneum lies on a basement membrane covering stromal tissue. This stroma contains a collagen-based matrix (collagen types I and III), blood and lymphatic vessels, nerve fibers and fibroblastic-like cells (Figure 6). The peritoneum is considered as a tertiary lymphoid organ that allows fast mobilization and recruitment of the inflammatory machinery to overcome abdominal injury or infection. Hence many inflammatory cytokines are up regulated in ovarian cancer ascites. Mesothelial cells also contribute to peritoneal fluid dialysis, abdominal healing and formation of adherences [141,142]. Therefore, the peritoneum constitutes a functional and anatomical barrier against intra-abdominal aggression and is considered as the first line of defense against cancer spread [143,144].Figure 5


Role of mesenchymal cells in the natural history of ovarian cancer: a review.

Touboul C, Vidal F, Pasquier J, Lis R, Rafii A - J Transl Med (2014)

Pathological aspects of normal peritoneum and peritoneal metastasis.
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4197295&req=5

Fig6: Pathological aspects of normal peritoneum and peritoneal metastasis.
Mentions: Clinical presentation at baseline in patients with advanced stages includes ascites, peritoneal carcinomatosis and omental involvement [140] (Figure 4). The peritoneum is a complex organ constituting the microenvironment of ovarian cancer metastatic nodules (Figure 5). It is composed of a continuous mesothelial cell layer covering all abdominal organs except ovaries. The peritoneum lies on a basement membrane covering stromal tissue. This stroma contains a collagen-based matrix (collagen types I and III), blood and lymphatic vessels, nerve fibers and fibroblastic-like cells (Figure 6). The peritoneum is considered as a tertiary lymphoid organ that allows fast mobilization and recruitment of the inflammatory machinery to overcome abdominal injury or infection. Hence many inflammatory cytokines are up regulated in ovarian cancer ascites. Mesothelial cells also contribute to peritoneal fluid dialysis, abdominal healing and formation of adherences [141,142]. Therefore, the peritoneum constitutes a functional and anatomical barrier against intra-abdominal aggression and is considered as the first line of defense against cancer spread [143,144].Figure 5

Bottom Line: They play a role at different stages of the disease: survival and peritoneal infiltration at early stage, proliferation in distant sites, chemoresistance and recurrence at later stage.The dialogue between ovarian and mesenchymal stem cells induces the constitution of a pro-tumoral mesencrine niche.Understanding the dynamics of such interaction in a clinical setting might propose new therapeutic strategies.

View Article: PubMed Central - PubMed

Affiliation: Department of Obstetrics and Gynecology, Hôpital Intercommunal de Créteil, Université Paris Est, UPEC-Paris XII, 12 avenue de Verdun, 94000, Créteil, France. cyril.touboul@gmail.com.

ABSTRACT

Background: Ovarian cancer is the deadliest gynaecologic malignancy. Despite progresses in chemotherapy and ultra-radical surgeries, this locally metastatic disease presents a high rate of local recurrence advocating for the role of a peritoneal niche. For several years, it was believed that tumor initiation, progression and metastasis were merely due to the changes in the neoplastic cell population and the adjacent non-neoplastic tissues were regarded as bystanders. The importance of the tumor microenvironment and its cellular component emerged from studies on the histopathological sequence of changes at the interface between putative tumor cells and the surrounding non-neoplastic tissues during carcinogenesis.

Method: In this review we aimed to describe the pro-tumoral crosstalk between ovarian cancer and mesenchymal stem cells. A PubMed search was performed for articles published pertaining to mesenchymal stem cells and specific to ovarian cancer.

Results: Mesenchymal stem cells participate to an elaborate crosstalk through direct and paracrine interaction with ovarian cancer cells. They play a role at different stages of the disease: survival and peritoneal infiltration at early stage, proliferation in distant sites, chemoresistance and recurrence at later stage.

Conclusion: The dialogue between ovarian and mesenchymal stem cells induces the constitution of a pro-tumoral mesencrine niche. Understanding the dynamics of such interaction in a clinical setting might propose new therapeutic strategies.

No MeSH data available.


Related in: MedlinePlus