Limits...
Biomarkers of endothelial dysfunction in relation to impaired carbohydrate metabolism following pregnancy with gestational diabetes mellitus.

Göbl CS, Bozkurt L, Yarragudi R, Prikoszovich T, Tura A, Pacini G, Koppensteiner R, Kautzky-Willer A - Cardiovasc Diabetol (2014)

Bottom Line: Endothelial biomarkers were significantly associated with insulin sensitivity (sICAM-1: r = -0.23, p = 0.009; sVCAM-1: r = -0.22, p = 0.011; sE-selectin: r = -0.21, p = 0.018) as well as with GDM status and parameters of subtle inflammation.Accordingly, sE-selectin levels at the early post partum visit predicted a later development of the disease (HR =1.02 95%CI 1.01 to 1.04, p = 0.013), however, this was attenuated after adjustment for BMI.Elevated circulating markers of endothelial dysfunction in young females with GDM history might reflect an early stage on the pathway to the manifestation of future cardiometabolic disorders.

View Article: PubMed Central - PubMed

ABSTRACT

Background: History of gestational diabetes mellitus (GDM) identifies a very young population of females predisposed for type 2 diabetes and cardiovascular disease. Endothelial dysfunction might represent a shared precursor of both disorders. Hence, this study aimed to characterize endothelial biomarkers in relation to impaired insulin sensitivity and progression to overt diabetes early after index pregnancy.

Methods: 108 women with previous GDM and 40 controls were included three to six months after delivery and underwent specific metabolic assessments including a frequently sampled intravenous glucose tolerance test and an oral glucose tolerance test. Diabetes progression was assessed in females with pGDM over 10 years of follow-up. Circulating sICAM-1 (intracellular-adhesion-molecule-1), sVCAM-1 (vascular-cell-adhesion-molecule-1) and sE-selectin, representing biomarkers of endothelial dysfunction were assessed at baseline and annually over five years.

Results: Endothelial biomarkers were significantly associated with insulin sensitivity (sICAM-1: r = -0.23, p = 0.009; sVCAM-1: r = -0.22, p = 0.011; sE-selectin: r = -0.21, p = 0.018) as well as with GDM status and parameters of subtle inflammation. Analysis of long-term trajectories revealed constantly elevated sICAM-1 (p = 0.033) and sE-selectin (p = 0.007) in 25 subjects with diabetes progression. Accordingly, sE-selectin levels at the early post partum visit predicted a later development of the disease (HR =1.02 95%CI 1.01 to 1.04, p = 0.013), however, this was attenuated after adjustment for BMI.

Conclusions: Elevated circulating markers of endothelial dysfunction in young females with GDM history might reflect an early stage on the pathway to the manifestation of future cardiometabolic disorders. Timely identification of women at high risk and optimization of follow-up management might provide an opportunity to prevent disease progression.

Show MeSH

Related in: MedlinePlus

Association of baseline sICAM-1 (A), sVCAM-1 (B) and sE-selectin (C) with SI levels and the regression curve derived from regression analysis based on fractional polynomials.
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
getmorefigures.php?uid=PMC4197268&req=5

Fig2: Association of baseline sICAM-1 (A), sVCAM-1 (B) and sE-selectin (C) with SI levels and the regression curve derived from regression analysis based on fractional polynomials.

Mentions: A brief summary of the study sample in Table 1 shows that biomarkers of endothelial dysfunction at the baseline examination were highest in the pGDM-IR subgroup (Figure 1). This observation was also confirmed by analyses of continuous data, as sICAM-1, sVCAM-1, and sE-selectin were inversely related to SIFSIGT 3–6 month after delivery (Table 2). Regression models based on fractional polynomials revealed monotonic but non-linear relationships between insulin sensitivity at baseline (SIFSIGT) and sICAM-1 as well as sE-selectin, which were used in multivariable models (Figure 2). However, no association were observed between endothelial biomarkers and insulin secretion (Table 2).Table 1


Biomarkers of endothelial dysfunction in relation to impaired carbohydrate metabolism following pregnancy with gestational diabetes mellitus.

Göbl CS, Bozkurt L, Yarragudi R, Prikoszovich T, Tura A, Pacini G, Koppensteiner R, Kautzky-Willer A - Cardiovasc Diabetol (2014)

Association of baseline sICAM-1 (A), sVCAM-1 (B) and sE-selectin (C) with SI levels and the regression curve derived from regression analysis based on fractional polynomials.
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4197268&req=5

Fig2: Association of baseline sICAM-1 (A), sVCAM-1 (B) and sE-selectin (C) with SI levels and the regression curve derived from regression analysis based on fractional polynomials.
Mentions: A brief summary of the study sample in Table 1 shows that biomarkers of endothelial dysfunction at the baseline examination were highest in the pGDM-IR subgroup (Figure 1). This observation was also confirmed by analyses of continuous data, as sICAM-1, sVCAM-1, and sE-selectin were inversely related to SIFSIGT 3–6 month after delivery (Table 2). Regression models based on fractional polynomials revealed monotonic but non-linear relationships between insulin sensitivity at baseline (SIFSIGT) and sICAM-1 as well as sE-selectin, which were used in multivariable models (Figure 2). However, no association were observed between endothelial biomarkers and insulin secretion (Table 2).Table 1

Bottom Line: Endothelial biomarkers were significantly associated with insulin sensitivity (sICAM-1: r = -0.23, p = 0.009; sVCAM-1: r = -0.22, p = 0.011; sE-selectin: r = -0.21, p = 0.018) as well as with GDM status and parameters of subtle inflammation.Accordingly, sE-selectin levels at the early post partum visit predicted a later development of the disease (HR =1.02 95%CI 1.01 to 1.04, p = 0.013), however, this was attenuated after adjustment for BMI.Elevated circulating markers of endothelial dysfunction in young females with GDM history might reflect an early stage on the pathway to the manifestation of future cardiometabolic disorders.

View Article: PubMed Central - PubMed

ABSTRACT

Background: History of gestational diabetes mellitus (GDM) identifies a very young population of females predisposed for type 2 diabetes and cardiovascular disease. Endothelial dysfunction might represent a shared precursor of both disorders. Hence, this study aimed to characterize endothelial biomarkers in relation to impaired insulin sensitivity and progression to overt diabetes early after index pregnancy.

Methods: 108 women with previous GDM and 40 controls were included three to six months after delivery and underwent specific metabolic assessments including a frequently sampled intravenous glucose tolerance test and an oral glucose tolerance test. Diabetes progression was assessed in females with pGDM over 10 years of follow-up. Circulating sICAM-1 (intracellular-adhesion-molecule-1), sVCAM-1 (vascular-cell-adhesion-molecule-1) and sE-selectin, representing biomarkers of endothelial dysfunction were assessed at baseline and annually over five years.

Results: Endothelial biomarkers were significantly associated with insulin sensitivity (sICAM-1: r = -0.23, p = 0.009; sVCAM-1: r = -0.22, p = 0.011; sE-selectin: r = -0.21, p = 0.018) as well as with GDM status and parameters of subtle inflammation. Analysis of long-term trajectories revealed constantly elevated sICAM-1 (p = 0.033) and sE-selectin (p = 0.007) in 25 subjects with diabetes progression. Accordingly, sE-selectin levels at the early post partum visit predicted a later development of the disease (HR =1.02 95%CI 1.01 to 1.04, p = 0.013), however, this was attenuated after adjustment for BMI.

Conclusions: Elevated circulating markers of endothelial dysfunction in young females with GDM history might reflect an early stage on the pathway to the manifestation of future cardiometabolic disorders. Timely identification of women at high risk and optimization of follow-up management might provide an opportunity to prevent disease progression.

Show MeSH
Related in: MedlinePlus