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Factors affecting drug-induced liver injury: antithyroid drugs as instances.

Heidari R, Niknahad H, Jamshidzadeh A, Abdoli N - Clin Mol Hepatol (2014)

Bottom Line: The mechanism(s) of hepatic injury induced by antithyroid agents is not fully recognized yet.The purpose of this article is to give an overview on possible susceptibility factors in liver injury induced by antithyroid agents.Age, gender, metabolism characteristics, alcohol consumption, underlying diseases, immunologic mechanisms, and drug interactions are involved in enhancing antithyroid drugs-induced hepatic damage.

View Article: PubMed Central - PubMed

Affiliation: Pharmaceutical Sciences Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.

ABSTRACT
Methimazole and propylthiouracil have been used in the management of hyperthyroidism for more than half a century. However, hepatotoxicity is one of the most deleterious side effects associated with these medications. The mechanism(s) of hepatic injury induced by antithyroid agents is not fully recognized yet. Furthermore, there are no specific tools for predicting the occurrence of hepatotoxicity induced by these drugs. The purpose of this article is to give an overview on possible susceptibility factors in liver injury induced by antithyroid agents. Age, gender, metabolism characteristics, alcohol consumption, underlying diseases, immunologic mechanisms, and drug interactions are involved in enhancing antithyroid drugs-induced hepatic damage. An outline on the clinically used treatments for antithyroid drugs-induced hepatotoxicity and the potential therapeutic strategies found to be effective against this complication are also discussed.

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Related in: MedlinePlus

Susceptibility factors make patients more vulnerable to the toxicity induced by drugs. Presence of risk factors might make antithyroid drugs to be more hepatotoxic in lower doses.
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Figure 1: Susceptibility factors make patients more vulnerable to the toxicity induced by drugs. Presence of risk factors might make antithyroid drugs to be more hepatotoxic in lower doses.

Mentions: There are numerous factors that can contribute to differences among individuals in their sensitivity to xenobiotics. These include variation in age, gender, chemical metabolism in liver, underlying disease, coexposure to additional xenobiotics, and dietary status. Moreover, environmental and genetic factors have the capacity to apply significant influences on the onset of these determinants. The presence of susceptibility factors might make patients vulnerable to hepatic injury induced by xenobiotics (Fig. 1) and non-toxic chemical (e.g drugs) might become hepatotoxic in lower doses in the presence of risk factors (Fig. 1).


Factors affecting drug-induced liver injury: antithyroid drugs as instances.

Heidari R, Niknahad H, Jamshidzadeh A, Abdoli N - Clin Mol Hepatol (2014)

Susceptibility factors make patients more vulnerable to the toxicity induced by drugs. Presence of risk factors might make antithyroid drugs to be more hepatotoxic in lower doses.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4197171&req=5

Figure 1: Susceptibility factors make patients more vulnerable to the toxicity induced by drugs. Presence of risk factors might make antithyroid drugs to be more hepatotoxic in lower doses.
Mentions: There are numerous factors that can contribute to differences among individuals in their sensitivity to xenobiotics. These include variation in age, gender, chemical metabolism in liver, underlying disease, coexposure to additional xenobiotics, and dietary status. Moreover, environmental and genetic factors have the capacity to apply significant influences on the onset of these determinants. The presence of susceptibility factors might make patients vulnerable to hepatic injury induced by xenobiotics (Fig. 1) and non-toxic chemical (e.g drugs) might become hepatotoxic in lower doses in the presence of risk factors (Fig. 1).

Bottom Line: The mechanism(s) of hepatic injury induced by antithyroid agents is not fully recognized yet.The purpose of this article is to give an overview on possible susceptibility factors in liver injury induced by antithyroid agents.Age, gender, metabolism characteristics, alcohol consumption, underlying diseases, immunologic mechanisms, and drug interactions are involved in enhancing antithyroid drugs-induced hepatic damage.

View Article: PubMed Central - PubMed

Affiliation: Pharmaceutical Sciences Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.

ABSTRACT
Methimazole and propylthiouracil have been used in the management of hyperthyroidism for more than half a century. However, hepatotoxicity is one of the most deleterious side effects associated with these medications. The mechanism(s) of hepatic injury induced by antithyroid agents is not fully recognized yet. Furthermore, there are no specific tools for predicting the occurrence of hepatotoxicity induced by these drugs. The purpose of this article is to give an overview on possible susceptibility factors in liver injury induced by antithyroid agents. Age, gender, metabolism characteristics, alcohol consumption, underlying diseases, immunologic mechanisms, and drug interactions are involved in enhancing antithyroid drugs-induced hepatic damage. An outline on the clinically used treatments for antithyroid drugs-induced hepatotoxicity and the potential therapeutic strategies found to be effective against this complication are also discussed.

Show MeSH
Related in: MedlinePlus