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Prediction of fibrosis progression in chronic viral hepatitis.

Wong GL - Clin Mol Hepatol (2014)

Bottom Line: The new notion of regression of advanced fibrosis or even cirrhosis is now strongly supported various clinical studies.Transient elastography is one of the most validated tools which has both diagnostic and prognostic role.As there is no single perfect test for liver fibrosis assessment, algorithms combining the most validated noninvasive methods should be considered as initial screening tools.

View Article: PubMed Central - PubMed

Affiliation: Institute of Digestive Disease, Department of Medicine and Therapeutics, and State Key Laboratory of Digestive Disease, The Chinese University of Hong Kong, Hong Kong SAR, China.

ABSTRACT
Prediction of liver fibrosis progression has a key role in the management of chronic viral hepatitis, as it will be translated into the future risk of cirrhosis and its various complications including hepatocellular carcinoma. Both hepatitis B and C viruses mainly lead to fibrogenesis induced by chronic inflammation and a continuous wound healing response. At the same time direct and indirect profibrogenic responses are also elicited by the viral infection. There are a handful of well-established risk factors for fibrosis progression including older age, male gender, alcohol use, high viral load and co-infection with other viruses. Metabolic syndrome is an evolving risk factor of fibrosis progression. The new notion of regression of advanced fibrosis or even cirrhosis is now strongly supported various clinical studies. Even liver biopsy retains its important role in the assessment of fibrosis progression, various non-invasive assessments have been adopted widely because of their non-invasiveness, which facilitates serial applications in large cohorts of subjects. Transient elastography is one of the most validated tools which has both diagnostic and prognostic role. As there is no single perfect test for liver fibrosis assessment, algorithms combining the most validated noninvasive methods should be considered as initial screening tools.

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Related in: MedlinePlus

Adjusted odds ratio (adjusted for the change in serum alanine aminotransferase and hepatitis B virus DNA levels) of new-onset metabolic syndrome and its factors for liver fibrosis progression and regression.28 HDL-C, high density lipoprotein cholesterol; TG, triglycerides.
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Related In: Results  -  Collection

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Figure 1: Adjusted odds ratio (adjusted for the change in serum alanine aminotransferase and hepatitis B virus DNA levels) of new-onset metabolic syndrome and its factors for liver fibrosis progression and regression.28 HDL-C, high density lipoprotein cholesterol; TG, triglycerides.


Prediction of fibrosis progression in chronic viral hepatitis.

Wong GL - Clin Mol Hepatol (2014)

Adjusted odds ratio (adjusted for the change in serum alanine aminotransferase and hepatitis B virus DNA levels) of new-onset metabolic syndrome and its factors for liver fibrosis progression and regression.28 HDL-C, high density lipoprotein cholesterol; TG, triglycerides.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4197170&req=5

Figure 1: Adjusted odds ratio (adjusted for the change in serum alanine aminotransferase and hepatitis B virus DNA levels) of new-onset metabolic syndrome and its factors for liver fibrosis progression and regression.28 HDL-C, high density lipoprotein cholesterol; TG, triglycerides.
Bottom Line: The new notion of regression of advanced fibrosis or even cirrhosis is now strongly supported various clinical studies.Transient elastography is one of the most validated tools which has both diagnostic and prognostic role.As there is no single perfect test for liver fibrosis assessment, algorithms combining the most validated noninvasive methods should be considered as initial screening tools.

View Article: PubMed Central - PubMed

Affiliation: Institute of Digestive Disease, Department of Medicine and Therapeutics, and State Key Laboratory of Digestive Disease, The Chinese University of Hong Kong, Hong Kong SAR, China.

ABSTRACT
Prediction of liver fibrosis progression has a key role in the management of chronic viral hepatitis, as it will be translated into the future risk of cirrhosis and its various complications including hepatocellular carcinoma. Both hepatitis B and C viruses mainly lead to fibrogenesis induced by chronic inflammation and a continuous wound healing response. At the same time direct and indirect profibrogenic responses are also elicited by the viral infection. There are a handful of well-established risk factors for fibrosis progression including older age, male gender, alcohol use, high viral load and co-infection with other viruses. Metabolic syndrome is an evolving risk factor of fibrosis progression. The new notion of regression of advanced fibrosis or even cirrhosis is now strongly supported various clinical studies. Even liver biopsy retains its important role in the assessment of fibrosis progression, various non-invasive assessments have been adopted widely because of their non-invasiveness, which facilitates serial applications in large cohorts of subjects. Transient elastography is one of the most validated tools which has both diagnostic and prognostic role. As there is no single perfect test for liver fibrosis assessment, algorithms combining the most validated noninvasive methods should be considered as initial screening tools.

Show MeSH
Related in: MedlinePlus