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Efficacy of Malarone(®) in dogs naturally infected with Babesia gibsoni.

Iguchi A, Shiranaga N, Matsuu A, Hikasa Y - J. Vet. Med. Sci. (2014)

Bottom Line: In all dogs except one treated with Malarone(®), parasitemia decreased, and anemia improved soon after initiation of treatment.All relapsed dogs responded well to the second treatment, but 1 dog relapsed again and did not respond to the third treatment.Malarone(®) may be useful for acute stage of B. gibsoni infections, and at least second repeating treatment might be effective.

View Article: PubMed Central - PubMed

Affiliation: Laboratory of Veterinary Internal Medicine, Joint Department of Veterinary Medicine, Faculty of Agriculture, Tottori University, Tottori 680-8553, Japan.

ABSTRACT
The efficacy of Malarone(®) alone and in combination with doxycycline (DOXY) against Babesia gibsoni infections was examined in 8 dogs. In all dogs except one treated with Malarone(®), parasitemia decreased, and anemia improved soon after initiation of treatment. However, 3 of 4 dogs treated with Malarone(®) relapsed, and relapse was inhibited in 2 of 4 dogs treated with Malarone(®) and DOXY. All relapsed dogs responded well to the second treatment, but 1 dog relapsed again and did not respond to the third treatment. Malarone(®) may be useful for acute stage of B. gibsoni infections, and at least second repeating treatment might be effective.

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Changes in PCV (○), number of PLT (■) and parasitemia (♦) in the 8 dogs. The period ofMalarone® (solid line) and/or DOXY (dot line) treatment is shown as bowsunder the figure.
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fig_001: Changes in PCV (○), number of PLT (■) and parasitemia (♦) in the 8 dogs. The period ofMalarone® (solid line) and/or DOXY (dot line) treatment is shown as bowsunder the figure.

Mentions: As shown in Table 1, the 8 dogs in this studyshowed mild to severe anemia and thrombocytopenia. In 3 of 4 cases treated withMalarone® therapy (dogs 1, 2 and 3); and in all cases treated with thecombination therapy (dogs 5–8), clinical signs of babesiosis, anemia and the number of PLTsimproved soon after initiation of treatment (Fig.1Fig. 1.


Efficacy of Malarone(®) in dogs naturally infected with Babesia gibsoni.

Iguchi A, Shiranaga N, Matsuu A, Hikasa Y - J. Vet. Med. Sci. (2014)

Changes in PCV (○), number of PLT (■) and parasitemia (♦) in the 8 dogs. The period ofMalarone® (solid line) and/or DOXY (dot line) treatment is shown as bowsunder the figure.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4197161&req=5

fig_001: Changes in PCV (○), number of PLT (■) and parasitemia (♦) in the 8 dogs. The period ofMalarone® (solid line) and/or DOXY (dot line) treatment is shown as bowsunder the figure.
Mentions: As shown in Table 1, the 8 dogs in this studyshowed mild to severe anemia and thrombocytopenia. In 3 of 4 cases treated withMalarone® therapy (dogs 1, 2 and 3); and in all cases treated with thecombination therapy (dogs 5–8), clinical signs of babesiosis, anemia and the number of PLTsimproved soon after initiation of treatment (Fig.1Fig. 1.

Bottom Line: In all dogs except one treated with Malarone(®), parasitemia decreased, and anemia improved soon after initiation of treatment.All relapsed dogs responded well to the second treatment, but 1 dog relapsed again and did not respond to the third treatment.Malarone(®) may be useful for acute stage of B. gibsoni infections, and at least second repeating treatment might be effective.

View Article: PubMed Central - PubMed

Affiliation: Laboratory of Veterinary Internal Medicine, Joint Department of Veterinary Medicine, Faculty of Agriculture, Tottori University, Tottori 680-8553, Japan.

ABSTRACT
The efficacy of Malarone(®) alone and in combination with doxycycline (DOXY) against Babesia gibsoni infections was examined in 8 dogs. In all dogs except one treated with Malarone(®), parasitemia decreased, and anemia improved soon after initiation of treatment. However, 3 of 4 dogs treated with Malarone(®) relapsed, and relapse was inhibited in 2 of 4 dogs treated with Malarone(®) and DOXY. All relapsed dogs responded well to the second treatment, but 1 dog relapsed again and did not respond to the third treatment. Malarone(®) may be useful for acute stage of B. gibsoni infections, and at least second repeating treatment might be effective.

Show MeSH
Related in: MedlinePlus