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Pathological and immunohistochemical findings of natural highly pathogenic avian influenza infection in tufted ducks during 2010-2011 outbreaks in Japan.

Abdo W, Haridy M, Katou Y, Goto M, Mizoguchi T, Sakoda Y, Sakai H, Yanai T - J. Vet. Med. Sci. (2014)

Bottom Line: Tufted ducks were found dead in an urban area of Toyota City, Koriyama, Fukushima Prefecture.HPAIV antigen was detected in the malacic areas, neuronal, glial and ependymal cells, pulmonary capillary endothelial cells and epithelium of pulmonary bronchioles, necrotic pancreatic acini and degenerated cardiac myocytes.The HPAIV isolate was genetically classified into clade 2.3.2.1 group A.

View Article: PubMed Central - PubMed

Affiliation: Department of Pathogenetic Veterinary Sciences, United Graduate School of Veterinary Sciences, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan.

ABSTRACT
In the winter of 2010-2011, an outbreak of highly pathogenic avian influenza virus (HPAIV) infection occurred in wild and domestic birds in Japan. Tufted ducks were found dead in an urban area of Toyota City, Koriyama, Fukushima Prefecture. Two tufted ducks were examined histopathologically, immunohistochemically and molecularly. Gross findings included marked dark-red clotted blood in the pectoral muscles and multifocal hemorrhages on the serous membranes. Microscopically, non-suppurative meningoencephalitis, multifocal to coalescing pancreatic necrosis and severe pulmonary congestion were observed. HPAIV antigen was detected in the malacic areas, neuronal, glial and ependymal cells, pulmonary capillary endothelial cells and epithelium of pulmonary bronchioles, necrotic pancreatic acini and degenerated cardiac myocytes. The HPAIV isolate was genetically classified into clade 2.3.2.1 group A. The broad distribution of virus antigen in brain and pulmonary tissues associated with HPAIV spontaneous infection in tufted ducks might be useful in understanding its pathogenesis in nature.

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Related in: MedlinePlus

Gross and histopathological findings of HPAIV in tufted ducks. Lesions werecharacterized grossly by (a) marked dark-red clotted blood in the pectoral muscles and(b) multifocal hemorrhages on the serosal surface of the liver and pericardium and (c)in the lungs. (d) The histopathological findings in brain of tufted ducks werenon-suppurative meningoencephalitis characterized by perivascular mononuclear cellcuffing, multifocal neuronal degeneration and gliosis.
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fig_001: Gross and histopathological findings of HPAIV in tufted ducks. Lesions werecharacterized grossly by (a) marked dark-red clotted blood in the pectoral muscles and(b) multifocal hemorrhages on the serosal surface of the liver and pericardium and (c)in the lungs. (d) The histopathological findings in brain of tufted ducks werenon-suppurative meningoencephalitis characterized by perivascular mononuclear cellcuffing, multifocal neuronal degeneration and gliosis.

Mentions: Grossly, the birds showed normal body mass (weighing 2.520 & 1.7 kg, both females) withsalivation, eye discharge and bilateral bloody discharge. The main gross pathological featureswere marked dark-reddish clotted blood in the pectoral muscles (Fig. 1aFig. 1.


Pathological and immunohistochemical findings of natural highly pathogenic avian influenza infection in tufted ducks during 2010-2011 outbreaks in Japan.

Abdo W, Haridy M, Katou Y, Goto M, Mizoguchi T, Sakoda Y, Sakai H, Yanai T - J. Vet. Med. Sci. (2014)

Gross and histopathological findings of HPAIV in tufted ducks. Lesions werecharacterized grossly by (a) marked dark-red clotted blood in the pectoral muscles and(b) multifocal hemorrhages on the serosal surface of the liver and pericardium and (c)in the lungs. (d) The histopathological findings in brain of tufted ducks werenon-suppurative meningoencephalitis characterized by perivascular mononuclear cellcuffing, multifocal neuronal degeneration and gliosis.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4197160&req=5

fig_001: Gross and histopathological findings of HPAIV in tufted ducks. Lesions werecharacterized grossly by (a) marked dark-red clotted blood in the pectoral muscles and(b) multifocal hemorrhages on the serosal surface of the liver and pericardium and (c)in the lungs. (d) The histopathological findings in brain of tufted ducks werenon-suppurative meningoencephalitis characterized by perivascular mononuclear cellcuffing, multifocal neuronal degeneration and gliosis.
Mentions: Grossly, the birds showed normal body mass (weighing 2.520 & 1.7 kg, both females) withsalivation, eye discharge and bilateral bloody discharge. The main gross pathological featureswere marked dark-reddish clotted blood in the pectoral muscles (Fig. 1aFig. 1.

Bottom Line: Tufted ducks were found dead in an urban area of Toyota City, Koriyama, Fukushima Prefecture.HPAIV antigen was detected in the malacic areas, neuronal, glial and ependymal cells, pulmonary capillary endothelial cells and epithelium of pulmonary bronchioles, necrotic pancreatic acini and degenerated cardiac myocytes.The HPAIV isolate was genetically classified into clade 2.3.2.1 group A.

View Article: PubMed Central - PubMed

Affiliation: Department of Pathogenetic Veterinary Sciences, United Graduate School of Veterinary Sciences, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan.

ABSTRACT
In the winter of 2010-2011, an outbreak of highly pathogenic avian influenza virus (HPAIV) infection occurred in wild and domestic birds in Japan. Tufted ducks were found dead in an urban area of Toyota City, Koriyama, Fukushima Prefecture. Two tufted ducks were examined histopathologically, immunohistochemically and molecularly. Gross findings included marked dark-red clotted blood in the pectoral muscles and multifocal hemorrhages on the serous membranes. Microscopically, non-suppurative meningoencephalitis, multifocal to coalescing pancreatic necrosis and severe pulmonary congestion were observed. HPAIV antigen was detected in the malacic areas, neuronal, glial and ependymal cells, pulmonary capillary endothelial cells and epithelium of pulmonary bronchioles, necrotic pancreatic acini and degenerated cardiac myocytes. The HPAIV isolate was genetically classified into clade 2.3.2.1 group A. The broad distribution of virus antigen in brain and pulmonary tissues associated with HPAIV spontaneous infection in tufted ducks might be useful in understanding its pathogenesis in nature.

Show MeSH
Related in: MedlinePlus