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Effects of vitamin a status on expression of ucp1 and brown/beige adipocyte-related genes in white adipose tissues of beef cattle.

Kanamori Y, Yamada T, Asano H, Kida R, Qiao Y, Abd Eldaim MA, Tomonaga S, Matsui T, Funaba M - J. Vet. Med. Sci. (2014)

Bottom Line: We previously reported the presence of brown/beige adipocytes in the white fat depots of mature cattle.The present study examined the effects of dietary vitamin A on the expression of brown/beige adipocyte-related genes in the white fat depots of fattening cattle.The present results suggest that a vitamin A deficiency does not markedly affect the expression of Ucp1 in white fat depots, but imply that it may stimulate the emergence of beige adipocytes in the mesenteric fat depots of fattening cattle.

View Article: PubMed Central - PubMed

Affiliation: Division of Applied Biosciences, Graduate School of Agriculture, Kyoto University, Kyoto 606-8502, Japan.

ABSTRACT
We previously reported the presence of brown/beige adipocytes in the white fat depots of mature cattle. The present study examined the effects of dietary vitamin A on the expression of brown/beige adipocyte-related genes in the white fat depots of fattening cattle. No significant differences were observed in the expression of Ucp1 between vitamin A-deficient cattle and control cattle. However, the expression of the other brown/beige adipocyte-related genes was slightly higher in the mesenteric fat depots of vitamin A-deficient cattle. The present results suggest that a vitamin A deficiency does not markedly affect the expression of Ucp1 in white fat depots, but imply that it may stimulate the emergence of beige adipocytes in the mesenteric fat depots of fattening cattle.

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Expression of Ucp1, Fabp4 and Prdm16 in the white fat depots of fattening cattle.Fattening cattle were fed either a control diet or vitamin A-deficient (Vit A-def) dietfor 20 months. At 30 months of age, subcutaneous (sc), mesenteric (mesen), perirenal(pr), intermuscular (inter) and intramuscular (intra) WAT depots were collected, and theexpression of Ucp1 (A), Fabp4 (B) and Prdm16 (C) was examined by RT-qPCR. Expressionlevels were normalized to Hprt1 expression, and expression levels in each WAT depot inthe control group were set to 100. Data are shown as the mean ± SE (n=4).*P<0.05.
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fig_001: Expression of Ucp1, Fabp4 and Prdm16 in the white fat depots of fattening cattle.Fattening cattle were fed either a control diet or vitamin A-deficient (Vit A-def) dietfor 20 months. At 30 months of age, subcutaneous (sc), mesenteric (mesen), perirenal(pr), intermuscular (inter) and intramuscular (intra) WAT depots were collected, and theexpression of Ucp1 (A), Fabp4 (B) and Prdm16 (C) was examined by RT-qPCR. Expressionlevels were normalized to Hprt1 expression, and expression levels in each WAT depot inthe control group were set to 100. Data are shown as the mean ± SE (n=4).*P<0.05.

Mentions: No significant differences were observed in the expression of Ucp1 in all white fat depotsbetween the control and vitamin A-deficient groups (Fig.1AFig. 1.


Effects of vitamin a status on expression of ucp1 and brown/beige adipocyte-related genes in white adipose tissues of beef cattle.

Kanamori Y, Yamada T, Asano H, Kida R, Qiao Y, Abd Eldaim MA, Tomonaga S, Matsui T, Funaba M - J. Vet. Med. Sci. (2014)

Expression of Ucp1, Fabp4 and Prdm16 in the white fat depots of fattening cattle.Fattening cattle were fed either a control diet or vitamin A-deficient (Vit A-def) dietfor 20 months. At 30 months of age, subcutaneous (sc), mesenteric (mesen), perirenal(pr), intermuscular (inter) and intramuscular (intra) WAT depots were collected, and theexpression of Ucp1 (A), Fabp4 (B) and Prdm16 (C) was examined by RT-qPCR. Expressionlevels were normalized to Hprt1 expression, and expression levels in each WAT depot inthe control group were set to 100. Data are shown as the mean ± SE (n=4).*P<0.05.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4197155&req=5

fig_001: Expression of Ucp1, Fabp4 and Prdm16 in the white fat depots of fattening cattle.Fattening cattle were fed either a control diet or vitamin A-deficient (Vit A-def) dietfor 20 months. At 30 months of age, subcutaneous (sc), mesenteric (mesen), perirenal(pr), intermuscular (inter) and intramuscular (intra) WAT depots were collected, and theexpression of Ucp1 (A), Fabp4 (B) and Prdm16 (C) was examined by RT-qPCR. Expressionlevels were normalized to Hprt1 expression, and expression levels in each WAT depot inthe control group were set to 100. Data are shown as the mean ± SE (n=4).*P<0.05.
Mentions: No significant differences were observed in the expression of Ucp1 in all white fat depotsbetween the control and vitamin A-deficient groups (Fig.1AFig. 1.

Bottom Line: We previously reported the presence of brown/beige adipocytes in the white fat depots of mature cattle.The present study examined the effects of dietary vitamin A on the expression of brown/beige adipocyte-related genes in the white fat depots of fattening cattle.The present results suggest that a vitamin A deficiency does not markedly affect the expression of Ucp1 in white fat depots, but imply that it may stimulate the emergence of beige adipocytes in the mesenteric fat depots of fattening cattle.

View Article: PubMed Central - PubMed

Affiliation: Division of Applied Biosciences, Graduate School of Agriculture, Kyoto University, Kyoto 606-8502, Japan.

ABSTRACT
We previously reported the presence of brown/beige adipocytes in the white fat depots of mature cattle. The present study examined the effects of dietary vitamin A on the expression of brown/beige adipocyte-related genes in the white fat depots of fattening cattle. No significant differences were observed in the expression of Ucp1 between vitamin A-deficient cattle and control cattle. However, the expression of the other brown/beige adipocyte-related genes was slightly higher in the mesenteric fat depots of vitamin A-deficient cattle. The present results suggest that a vitamin A deficiency does not markedly affect the expression of Ucp1 in white fat depots, but imply that it may stimulate the emergence of beige adipocytes in the mesenteric fat depots of fattening cattle.

Show MeSH
Related in: MedlinePlus