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Glycopolymer code based on well-defined glycopolymers or glyconanomaterials and their biomolecular recognition.

Yilmaz G, Becer CR - Front Bioeng Biotechnol (2014)

Bottom Line: In the last decade, functionalized self-assembled/decided nano-objects and scaffolds containing glycopolymers were designed to develop many biological and biomedical applications in diseases treatments such as pathogen detection, inhibitors of toxins, and lectin-based biosensors.These studies will facilitate the understanding and investigation of the sugar code on the carbohydrate-lectin interactions, which are significantly influenced by the glycopolymer architecture, valency, size, and density of binding elements.In this context, these advanced and selected glycopolymers/particles showing specific interactions with various lectins are highlighted.

View Article: PubMed Central - PubMed

Affiliation: Department of Chemistry, University of Warwick , Coventry , UK ; Department of Basic Sciences, Turkish Military Academy , Ankara , Turkey.

ABSTRACT
Advances in the glycopolymer technology have allowed the preparation of more complex and well-defined glycopolymers/particles with several architectures from linear to globular structures (such as micelles, dendrimers, and nanogels). In the last decade, functionalized self-assembled/decided nano-objects and scaffolds containing glycopolymers were designed to develop many biological and biomedical applications in diseases treatments such as pathogen detection, inhibitors of toxins, and lectin-based biosensors. These studies will facilitate the understanding and investigation of the sugar code on the carbohydrate-lectin interactions, which are significantly influenced by the glycopolymer architecture, valency, size, and density of binding elements. In this context, these advanced and selected glycopolymers/particles showing specific interactions with various lectins are highlighted.

No MeSH data available.


General strategy for the synthesis of single-chain sugar arrays. Experimental conditions: (a) K2CO3, MeOH/H2O/THF, 40°C, 7 h; (b) CuBr, 4,4′-di-n-nonyl-2,2′-bipyridine, DMF, room temperature; (c) K2CO3, MeOH/H2O/THF, 60°C, 89 h; (d) TBAF, THF, room temperature, overnight. DMF, N,N-dimethylformamide, NMP, nitroxide-mediated polymerization; TBAF, tetrabutylammonium fluoride (Baradel et al., 2013).
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Figure 2: General strategy for the synthesis of single-chain sugar arrays. Experimental conditions: (a) K2CO3, MeOH/H2O/THF, 40°C, 7 h; (b) CuBr, 4,4′-di-n-nonyl-2,2′-bipyridine, DMF, room temperature; (c) K2CO3, MeOH/H2O/THF, 60°C, 89 h; (d) TBAF, THF, room temperature, overnight. DMF, N,N-dimethylformamide, NMP, nitroxide-mediated polymerization; TBAF, tetrabutylammonium fluoride (Baradel et al., 2013).

Mentions: An elegant approach to prepare precision glycopolymers in a convenient manner was reported by Baradel et al. (2013). They have utilized a combination of “living” radical polymerization technique and copper-catalyzed azide–alkyne cycloaddition (CuAAC). The NMP was performed to yield copolymers of styrene and maleimides (MIs) derivatives. Polymerization kinetics of these monomers showed a marked influence on macromolecular sequences and lead to efficient sequence controlled. The polymerization reaction was carried out in anisole at 120°C using alkoxyamine BlocBuilder as an initiator. The time-controlled addition of the protected MIs (three equivalents) during the polymerization of styrene, provided linear polystyrene chains presenting short but localized glycol functional regions (PDI = 1.23–1.24). Initially, triisopropylsilyl protected N-propargylmaleimide (TIPS-PMI) monomer was polymerized at the beginning of the reaction and then triethylsilyl protected N-propargylmaleimide (TES-PMI) was introduced after reaching full conversion of TIPS-PMI and further chain growth with styrene. Finally, trimethylsilyl protected N-propargylmaleimide (TMS-PMI) was added close to the end of the polymer chain due to their potential sensitivity to the reaction conditions (Figure 2). The precise chain positioning of all three reactive MIs was confirmed by the study of the kinetics of copolymerization.


Glycopolymer code based on well-defined glycopolymers or glyconanomaterials and their biomolecular recognition.

Yilmaz G, Becer CR - Front Bioeng Biotechnol (2014)

General strategy for the synthesis of single-chain sugar arrays. Experimental conditions: (a) K2CO3, MeOH/H2O/THF, 40°C, 7 h; (b) CuBr, 4,4′-di-n-nonyl-2,2′-bipyridine, DMF, room temperature; (c) K2CO3, MeOH/H2O/THF, 60°C, 89 h; (d) TBAF, THF, room temperature, overnight. DMF, N,N-dimethylformamide, NMP, nitroxide-mediated polymerization; TBAF, tetrabutylammonium fluoride (Baradel et al., 2013).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4196633&req=5

Figure 2: General strategy for the synthesis of single-chain sugar arrays. Experimental conditions: (a) K2CO3, MeOH/H2O/THF, 40°C, 7 h; (b) CuBr, 4,4′-di-n-nonyl-2,2′-bipyridine, DMF, room temperature; (c) K2CO3, MeOH/H2O/THF, 60°C, 89 h; (d) TBAF, THF, room temperature, overnight. DMF, N,N-dimethylformamide, NMP, nitroxide-mediated polymerization; TBAF, tetrabutylammonium fluoride (Baradel et al., 2013).
Mentions: An elegant approach to prepare precision glycopolymers in a convenient manner was reported by Baradel et al. (2013). They have utilized a combination of “living” radical polymerization technique and copper-catalyzed azide–alkyne cycloaddition (CuAAC). The NMP was performed to yield copolymers of styrene and maleimides (MIs) derivatives. Polymerization kinetics of these monomers showed a marked influence on macromolecular sequences and lead to efficient sequence controlled. The polymerization reaction was carried out in anisole at 120°C using alkoxyamine BlocBuilder as an initiator. The time-controlled addition of the protected MIs (three equivalents) during the polymerization of styrene, provided linear polystyrene chains presenting short but localized glycol functional regions (PDI = 1.23–1.24). Initially, triisopropylsilyl protected N-propargylmaleimide (TIPS-PMI) monomer was polymerized at the beginning of the reaction and then triethylsilyl protected N-propargylmaleimide (TES-PMI) was introduced after reaching full conversion of TIPS-PMI and further chain growth with styrene. Finally, trimethylsilyl protected N-propargylmaleimide (TMS-PMI) was added close to the end of the polymer chain due to their potential sensitivity to the reaction conditions (Figure 2). The precise chain positioning of all three reactive MIs was confirmed by the study of the kinetics of copolymerization.

Bottom Line: In the last decade, functionalized self-assembled/decided nano-objects and scaffolds containing glycopolymers were designed to develop many biological and biomedical applications in diseases treatments such as pathogen detection, inhibitors of toxins, and lectin-based biosensors.These studies will facilitate the understanding and investigation of the sugar code on the carbohydrate-lectin interactions, which are significantly influenced by the glycopolymer architecture, valency, size, and density of binding elements.In this context, these advanced and selected glycopolymers/particles showing specific interactions with various lectins are highlighted.

View Article: PubMed Central - PubMed

Affiliation: Department of Chemistry, University of Warwick , Coventry , UK ; Department of Basic Sciences, Turkish Military Academy , Ankara , Turkey.

ABSTRACT
Advances in the glycopolymer technology have allowed the preparation of more complex and well-defined glycopolymers/particles with several architectures from linear to globular structures (such as micelles, dendrimers, and nanogels). In the last decade, functionalized self-assembled/decided nano-objects and scaffolds containing glycopolymers were designed to develop many biological and biomedical applications in diseases treatments such as pathogen detection, inhibitors of toxins, and lectin-based biosensors. These studies will facilitate the understanding and investigation of the sugar code on the carbohydrate-lectin interactions, which are significantly influenced by the glycopolymer architecture, valency, size, and density of binding elements. In this context, these advanced and selected glycopolymers/particles showing specific interactions with various lectins are highlighted.

No MeSH data available.