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Fungal glycans and the innate immune recognition.

Barreto-Bergter E, Figueiredo RT - Front Cell Infect Microbiol (2014)

Bottom Line: Polysaccharides such as α- and β-glucans, chitin, and glycoproteins extensively modified with both N- and O-linked carbohydrates are the major components of fungal surfaces.The fungal cell wall is an excellent target for the action of antifungal agents, since most of its components are absent from mammalian cells.This review will discuss the structure of surface fungal glycoconjugates and polysaccharides and their recognition by innate immune receptors.

View Article: PubMed Central - PubMed

Affiliation: Departamento de Microbiologia Geral, Instituto de Microbiologia, Universidade Federal do Rio de Janeiro Rio de Janeiro, Brazil.

ABSTRACT
Polysaccharides such as α- and β-glucans, chitin, and glycoproteins extensively modified with both N- and O-linked carbohydrates are the major components of fungal surfaces. The fungal cell wall is an excellent target for the action of antifungal agents, since most of its components are absent from mammalian cells. Recognition of these carbohydrate-containing molecules by the innate immune system triggers inflammatory responses and activation of microbicidal mechanisms by leukocytes. This review will discuss the structure of surface fungal glycoconjugates and polysaccharides and their recognition by innate immune receptors.

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Related in: MedlinePlus

Schematic representation of the major cell wall components of the fungi A. fumigatus, C. albicans, Scedosporium/Pseudallescheria complex.
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Figure 1: Schematic representation of the major cell wall components of the fungi A. fumigatus, C. albicans, Scedosporium/Pseudallescheria complex.

Mentions: Polysaccharides and glycoconjugates are the major components of the fungal surface. Their structures vary among filamentous fungi and yeast and also among fungal species (Figure 1). The variety of carbohydrate structures present in the different fungal pathogens offers exceptional targets for the innate immune recognition which has evolved to recognize specific fungal glycans through a plethora of different receptors (Figure 2). Thus, the identification of fungal carbohydrates and their recognition by pattern recognition receptors must bring important contributions to the comprehension of the pathogenesis and immunity to fungal infections, and this must reveal new opportunities for the development of new classes of immunomodulators, antigens, and adjuvants.


Fungal glycans and the innate immune recognition.

Barreto-Bergter E, Figueiredo RT - Front Cell Infect Microbiol (2014)

Schematic representation of the major cell wall components of the fungi A. fumigatus, C. albicans, Scedosporium/Pseudallescheria complex.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4196476&req=5

Figure 1: Schematic representation of the major cell wall components of the fungi A. fumigatus, C. albicans, Scedosporium/Pseudallescheria complex.
Mentions: Polysaccharides and glycoconjugates are the major components of the fungal surface. Their structures vary among filamentous fungi and yeast and also among fungal species (Figure 1). The variety of carbohydrate structures present in the different fungal pathogens offers exceptional targets for the innate immune recognition which has evolved to recognize specific fungal glycans through a plethora of different receptors (Figure 2). Thus, the identification of fungal carbohydrates and their recognition by pattern recognition receptors must bring important contributions to the comprehension of the pathogenesis and immunity to fungal infections, and this must reveal new opportunities for the development of new classes of immunomodulators, antigens, and adjuvants.

Bottom Line: Polysaccharides such as α- and β-glucans, chitin, and glycoproteins extensively modified with both N- and O-linked carbohydrates are the major components of fungal surfaces.The fungal cell wall is an excellent target for the action of antifungal agents, since most of its components are absent from mammalian cells.This review will discuss the structure of surface fungal glycoconjugates and polysaccharides and their recognition by innate immune receptors.

View Article: PubMed Central - PubMed

Affiliation: Departamento de Microbiologia Geral, Instituto de Microbiologia, Universidade Federal do Rio de Janeiro Rio de Janeiro, Brazil.

ABSTRACT
Polysaccharides such as α- and β-glucans, chitin, and glycoproteins extensively modified with both N- and O-linked carbohydrates are the major components of fungal surfaces. The fungal cell wall is an excellent target for the action of antifungal agents, since most of its components are absent from mammalian cells. Recognition of these carbohydrate-containing molecules by the innate immune system triggers inflammatory responses and activation of microbicidal mechanisms by leukocytes. This review will discuss the structure of surface fungal glycoconjugates and polysaccharides and their recognition by innate immune receptors.

Show MeSH
Related in: MedlinePlus