Limits...
Extranodal marginal zone B-cell lymphoma of Mucosa-Associated Lymphoid Tissue (MALT lymphoma) in ulcerative colitis.

Terada T - Saudi J Gastroenterol (2014 Sep-Oct)

Bottom Line: Immunohistochemically, the atypical lymphocytes were positive for vimentin, CD45, CD20, CD79α, CD138, κ-chain, λ-chain, and p53 and Ki-67 antigen (labeling index = 63%).They were also positive for CD45RO, CD3, and CD15, but these positive cells were very scant compared with CD20 and CD79α.They were negative for CD10, CD30, CD56, cytokeratin (CK) AE1/3, CK CAM5.2, CK34BE12, CK5, CK6, CK7, CK8, CK14, CK18, CK19, CK20, EMA, chromogranin, synaptophysin, NSE, S100 protein, CEA, CA19-9, p63, and HMB45.

View Article: PubMed Central - PubMed

Affiliation: Department of Pathology, Shizuoka City Shimizu Hospital, Shizuoka, Japan.

ABSTRACT
Extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) occurring in inflammatory bowel diseases, including ulcerative colitis (UC) and Crohn's disease, has been reported, although it is extremely rare. An 18-year-old man with a two-years history of UC underwent colon endoscopy, and was found to have active total UC ranging from anus to cecum. Six biopsies were obtained. The microscopic examinations showed severe infiltrations of atypical small lymphocytes. They showed hyperchromatic nuclei and increased nucleocytoplasmic ratio and scattered immunoblastic cells. Centrocyte-like atypical lymphocytes, monocytoid cells, and plasma cells were seen in some places. Vague germinal centers were present, and apparent lymphoepithelial lesions were seen. No crypt abscesses were seen, and there were few neutrophils. No apparent other findings of UC were seen. Immunohistochemically, the atypical lymphocytes were positive for vimentin, CD45, CD20, CD79α, CD138, κ-chain, λ-chain, and p53 and Ki-67 antigen (labeling index = 63%). They were also positive for CD45RO, CD3, and CD15, but these positive cells were very scant compared with CD20 and CD79α. They were negative for CD10, CD30, CD56, cytokeratin (CK) AE1/3, CK CAM5.2, CK34BE12, CK5, CK6, CK7, CK8, CK14, CK18, CK19, CK20, EMA, chromogranin, synaptophysin, NSE, S100 protein, CEA, CA19-9, p63, and HMB45. Without clinical information, the appearances are those of MALT lymphoma. However, with clinical information, making the diagnosis of MALT lymphoma was hesitated. It is only mentioned herein that atypical lymphocytic infiltrations indistinguishable from MALT lymphoma occurred in an 18-year-old male patient with a two-year history of UC.

Show MeSH

Related in: MedlinePlus

Histological findings. (A) Low power view of the one specimen of colon biopsies. Severe atypical lymphoid infiltrates are seen. (B) High power view. It is evident that the lymphoid infiltrates are composed of atypical small lymphocytes reminiscent of centrocytes-like features. Monocytoid atypical cells, plasmacytoid atypical cells, and immunoblastic cells were seen. Mitotic figures were also seen. Germinal centers and lymphepithelial lesions are seen. (A): hematoxylin and eosin (H and E), ×100. (B) (H and E), ×200
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4196349&req=5

Figure 1: Histological findings. (A) Low power view of the one specimen of colon biopsies. Severe atypical lymphoid infiltrates are seen. (B) High power view. It is evident that the lymphoid infiltrates are composed of atypical small lymphocytes reminiscent of centrocytes-like features. Monocytoid atypical cells, plasmacytoid atypical cells, and immunoblastic cells were seen. Mitotic figures were also seen. Germinal centers and lymphepithelial lesions are seen. (A): hematoxylin and eosin (H and E), ×100. (B) (H and E), ×200

Mentions: The microscopic examinations of all the six biopsies showed severe infiltration of atypical small lymphocytes [Figure 1A, B]. They showed hyperchromatic nuclei and increased nucleocytoplasmic ratio. Immunoblastic cells were scattered. Centrocyte-like atypical lymphocytes (CCLs), monocytoid cells, and plasma cell differentiations were seen in some places. Vague germinal centers were present, and apparent lymphoepithelial lesions (LELs) were seen [Figure 1A, Bb]. No crypt abscesses were seen, and there were few neutrophils. No apparent features of UC such as crypt abscess, deletion of goblet cells, abnormal branching of the crypts and cryptal atrophy were seen. No Crohn's granuloma was seen.


Extranodal marginal zone B-cell lymphoma of Mucosa-Associated Lymphoid Tissue (MALT lymphoma) in ulcerative colitis.

Terada T - Saudi J Gastroenterol (2014 Sep-Oct)

Histological findings. (A) Low power view of the one specimen of colon biopsies. Severe atypical lymphoid infiltrates are seen. (B) High power view. It is evident that the lymphoid infiltrates are composed of atypical small lymphocytes reminiscent of centrocytes-like features. Monocytoid atypical cells, plasmacytoid atypical cells, and immunoblastic cells were seen. Mitotic figures were also seen. Germinal centers and lymphepithelial lesions are seen. (A): hematoxylin and eosin (H and E), ×100. (B) (H and E), ×200
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4196349&req=5

Figure 1: Histological findings. (A) Low power view of the one specimen of colon biopsies. Severe atypical lymphoid infiltrates are seen. (B) High power view. It is evident that the lymphoid infiltrates are composed of atypical small lymphocytes reminiscent of centrocytes-like features. Monocytoid atypical cells, plasmacytoid atypical cells, and immunoblastic cells were seen. Mitotic figures were also seen. Germinal centers and lymphepithelial lesions are seen. (A): hematoxylin and eosin (H and E), ×100. (B) (H and E), ×200
Mentions: The microscopic examinations of all the six biopsies showed severe infiltration of atypical small lymphocytes [Figure 1A, B]. They showed hyperchromatic nuclei and increased nucleocytoplasmic ratio. Immunoblastic cells were scattered. Centrocyte-like atypical lymphocytes (CCLs), monocytoid cells, and plasma cell differentiations were seen in some places. Vague germinal centers were present, and apparent lymphoepithelial lesions (LELs) were seen [Figure 1A, Bb]. No crypt abscesses were seen, and there were few neutrophils. No apparent features of UC such as crypt abscess, deletion of goblet cells, abnormal branching of the crypts and cryptal atrophy were seen. No Crohn's granuloma was seen.

Bottom Line: Immunohistochemically, the atypical lymphocytes were positive for vimentin, CD45, CD20, CD79α, CD138, κ-chain, λ-chain, and p53 and Ki-67 antigen (labeling index = 63%).They were also positive for CD45RO, CD3, and CD15, but these positive cells were very scant compared with CD20 and CD79α.They were negative for CD10, CD30, CD56, cytokeratin (CK) AE1/3, CK CAM5.2, CK34BE12, CK5, CK6, CK7, CK8, CK14, CK18, CK19, CK20, EMA, chromogranin, synaptophysin, NSE, S100 protein, CEA, CA19-9, p63, and HMB45.

View Article: PubMed Central - PubMed

Affiliation: Department of Pathology, Shizuoka City Shimizu Hospital, Shizuoka, Japan.

ABSTRACT
Extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) occurring in inflammatory bowel diseases, including ulcerative colitis (UC) and Crohn's disease, has been reported, although it is extremely rare. An 18-year-old man with a two-years history of UC underwent colon endoscopy, and was found to have active total UC ranging from anus to cecum. Six biopsies were obtained. The microscopic examinations showed severe infiltrations of atypical small lymphocytes. They showed hyperchromatic nuclei and increased nucleocytoplasmic ratio and scattered immunoblastic cells. Centrocyte-like atypical lymphocytes, monocytoid cells, and plasma cells were seen in some places. Vague germinal centers were present, and apparent lymphoepithelial lesions were seen. No crypt abscesses were seen, and there were few neutrophils. No apparent other findings of UC were seen. Immunohistochemically, the atypical lymphocytes were positive for vimentin, CD45, CD20, CD79α, CD138, κ-chain, λ-chain, and p53 and Ki-67 antigen (labeling index = 63%). They were also positive for CD45RO, CD3, and CD15, but these positive cells were very scant compared with CD20 and CD79α. They were negative for CD10, CD30, CD56, cytokeratin (CK) AE1/3, CK CAM5.2, CK34BE12, CK5, CK6, CK7, CK8, CK14, CK18, CK19, CK20, EMA, chromogranin, synaptophysin, NSE, S100 protein, CEA, CA19-9, p63, and HMB45. Without clinical information, the appearances are those of MALT lymphoma. However, with clinical information, making the diagnosis of MALT lymphoma was hesitated. It is only mentioned herein that atypical lymphocytic infiltrations indistinguishable from MALT lymphoma occurred in an 18-year-old male patient with a two-year history of UC.

Show MeSH
Related in: MedlinePlus