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Immunohistochemical study of CD44s expression in oral squamous cell carcinoma-its correlation with prognostic parameters.

Hema K, Rao K, Devi HU, Priya N, Smitha T, Sheethal H - J Oral Maxillofac Pathol (2014)

Bottom Line: A total of 30 cases of OSCC, - 10 cases of each well differentiated (WD SCC), moderately differentiated (MD SCC) and poorly differentiated squamous cell carcinomas (PD SCC) were included in the study.There was no statistical significance observed with respect to the other prognostic markers.Based on these observations it can be suggested that the decrease in expression of CD44s in OSCC cells may be due to the reduced cell-to-cell and cell-to-matrix adhesion, resulting in easy detachment from the rigid constitution.

View Article: PubMed Central - PubMed

Affiliation: Department of Oral and Maxillofacial Pathology, Vokkaligara Sangha Dental College and Research Centre, Bangaluru, Karnataka, India.

ABSTRACT

Background and objectives: The study aims at the observation of the immunohistochemical expression of CD44s in Oral Squamous Cell Carcinoma (OSCC) and to correlate its expression with prognostic parameters.

Materials and methods: A total of 30 cases of OSCC, - 10 cases of each well differentiated (WD SCC), moderately differentiated (MD SCC) and poorly differentiated squamous cell carcinomas (PD SCC) were included in the study. The sections were subjected to immunohistochemical study using CD44s antigen marker. The degree of intensity and distribution of CD44s immunostaining was assessed and correlated with prognostic markers such as tumor stage (tumor size), tumor grade (Broder's histological grading), tumor site, tumor thickness (histological depth of invasion) and nodal status.

Results: CD44s expression by tumor cells in OSCCs is statistically correlated with tumor grade i.e. Higher mean of CD44s immunoexpression was observed in WD SCC group (10.80 ± 3.97), followed by MD SCC group (5.90 ± 3.38) and PD SCC group showed least CD44s immunoexpression (3.70 ± 4.64). There was no statistical significance observed with respect to the other prognostic markers.

Conclusion: Based on these observations it can be suggested that the decrease in expression of CD44s in OSCC cells may be due to the reduced cell-to-cell and cell-to-matrix adhesion, resulting in easy detachment from the rigid constitution. Low expression of CD44s in OSCC tissues may be an indicator of tumor invasion and high metastatic potential.

No MeSH data available.


Related in: MedlinePlus

CD44s expression in tumor site
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Figure 11: CD44s expression in tumor site

Mentions: Association between CD44s immunoexpression and tumor site: The association between site and CD44s immunoexpression is not found to be statistically significant (P > 0.05). Both weakly positive and strongly positive cases were seen in higher numbers in buccal mucosal samples [Table 4, Graph 2]


Immunohistochemical study of CD44s expression in oral squamous cell carcinoma-its correlation with prognostic parameters.

Hema K, Rao K, Devi HU, Priya N, Smitha T, Sheethal H - J Oral Maxillofac Pathol (2014)

CD44s expression in tumor site
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4196281&req=5

Figure 11: CD44s expression in tumor site
Mentions: Association between CD44s immunoexpression and tumor site: The association between site and CD44s immunoexpression is not found to be statistically significant (P > 0.05). Both weakly positive and strongly positive cases were seen in higher numbers in buccal mucosal samples [Table 4, Graph 2]

Bottom Line: A total of 30 cases of OSCC, - 10 cases of each well differentiated (WD SCC), moderately differentiated (MD SCC) and poorly differentiated squamous cell carcinomas (PD SCC) were included in the study.There was no statistical significance observed with respect to the other prognostic markers.Based on these observations it can be suggested that the decrease in expression of CD44s in OSCC cells may be due to the reduced cell-to-cell and cell-to-matrix adhesion, resulting in easy detachment from the rigid constitution.

View Article: PubMed Central - PubMed

Affiliation: Department of Oral and Maxillofacial Pathology, Vokkaligara Sangha Dental College and Research Centre, Bangaluru, Karnataka, India.

ABSTRACT

Background and objectives: The study aims at the observation of the immunohistochemical expression of CD44s in Oral Squamous Cell Carcinoma (OSCC) and to correlate its expression with prognostic parameters.

Materials and methods: A total of 30 cases of OSCC, - 10 cases of each well differentiated (WD SCC), moderately differentiated (MD SCC) and poorly differentiated squamous cell carcinomas (PD SCC) were included in the study. The sections were subjected to immunohistochemical study using CD44s antigen marker. The degree of intensity and distribution of CD44s immunostaining was assessed and correlated with prognostic markers such as tumor stage (tumor size), tumor grade (Broder's histological grading), tumor site, tumor thickness (histological depth of invasion) and nodal status.

Results: CD44s expression by tumor cells in OSCCs is statistically correlated with tumor grade i.e. Higher mean of CD44s immunoexpression was observed in WD SCC group (10.80 ± 3.97), followed by MD SCC group (5.90 ± 3.38) and PD SCC group showed least CD44s immunoexpression (3.70 ± 4.64). There was no statistical significance observed with respect to the other prognostic markers.

Conclusion: Based on these observations it can be suggested that the decrease in expression of CD44s in OSCC cells may be due to the reduced cell-to-cell and cell-to-matrix adhesion, resulting in easy detachment from the rigid constitution. Low expression of CD44s in OSCC tissues may be an indicator of tumor invasion and high metastatic potential.

No MeSH data available.


Related in: MedlinePlus