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Eosinophilic nucleoli.

Bavle RM - J Oral Maxillofac Pathol (2014)

View Article: PubMed Central - PubMed

Affiliation: Editor-in-Chief-JOMFP, Department of Oral and Maxillofacial Pathology, Krishnadevaraya College of Dental Sciences, Bangalore - 562 157, Karnataka, India. E-mail: rad.iaomp@gmail.com.

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When observed under a microscope, the nucleus within the cells can either present as open phase nucleus or a closed phase nucleus... Open phase nucleus is also called as vesicular nucleus... It can exhibit marked variation in size and shape, occasionally with very large and bizarre forms... Usually no more than 2-3 nucleoli per cell are seen... In such cells, the nucleolus can be seen only during interphase... The most prominent substructure within the nucleus is the nucleolus... The ribosomal proteins are then transported from the cytoplasm to the nucleolus, where they are assembled with rRNAs to form pre-ribosomal particles... However, in a cell that is actively synthesizing proteins and possesses increased amounts of pre-ribosomal particles (protein factories), the nucleoli are positively charged and may stain amphophilic to eosinophilic owing to their very high protein content... The importance of ribosomal production is particularly evident in oocytes and actively growing mammalian cells in which the rRNA genes are amplified to support the synthesis of large number of ribosomes required to meet the need for protein synthesis... In cancerous cells, the cell's entry into cell cycle is always associated with up-regulation of the nucleolar function and increased nucleolar size, which is directly dependent on the rapidity of cell cycle proliferation... As the amount of pre-ribosomal proteins increase in these cancerous cells, they may exhibit amphophilic to eosinophilic nucleoli upon staining with hematoxylin and eosin stain... Few lesions/pathologies where eosinophilic nuclei can be encountered include: Classical Reed-Sternberg cells: The hallmark of Hodgkin's lymphoma is characterized by bilobed or multinucleated nucleus with prominent eosinophilic inclusions-like nucleoli resembling an “owl's eye” Malignant melanoma Myeloid sarcoma Carcinoid tumors Colon carcinoma Ewing's sarcoma Peripheral neuroectodermal tumor Rhabdomyosarcoma Olfactory neuroblastoma Nephroblastoma or Wilms’ tumor Poorly differentiated squamous cell carcinoma Anaplastic carcinoma... The cells were of varied morphology ranging from spindle to ovoid to epitheliod... They exhibited cellular and nuclear pleomorphism; increased mitoses and were almost completely devoid of melanin pigmentation... Most of the tumor cells showed the presence of eosinophilic nucleoli representing an actively synthesizing cell, which aided in arriving at a diagnosis of malignant melanoma.

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Related in: MedlinePlus

(a) Photomicrograph shows tumor cells with ill-defined cell borders, abundant cytoplasm and open phase nucleus with prominent eosinophilic nucleoli (H&E stain, ×400). (b) Hand-drawn illustration of the same
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Figure 1: (a) Photomicrograph shows tumor cells with ill-defined cell borders, abundant cytoplasm and open phase nucleus with prominent eosinophilic nucleoli (H&E stain, ×400). (b) Hand-drawn illustration of the same

Mentions: A high-power view of the tumor cells along with a hand-drawn illustration of the lesion is presented in Figure 1. The H and E stained images of the tumor cells is presented in Figure 2.


Eosinophilic nucleoli.

Bavle RM - J Oral Maxillofac Pathol (2014)

(a) Photomicrograph shows tumor cells with ill-defined cell borders, abundant cytoplasm and open phase nucleus with prominent eosinophilic nucleoli (H&E stain, ×400). (b) Hand-drawn illustration of the same
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4196279&req=5

Figure 1: (a) Photomicrograph shows tumor cells with ill-defined cell borders, abundant cytoplasm and open phase nucleus with prominent eosinophilic nucleoli (H&E stain, ×400). (b) Hand-drawn illustration of the same
Mentions: A high-power view of the tumor cells along with a hand-drawn illustration of the lesion is presented in Figure 1. The H and E stained images of the tumor cells is presented in Figure 2.

View Article: PubMed Central - PubMed

Affiliation: Editor-in-Chief-JOMFP, Department of Oral and Maxillofacial Pathology, Krishnadevaraya College of Dental Sciences, Bangalore - 562 157, Karnataka, India. E-mail: rad.iaomp@gmail.com.

AUTOMATICALLY GENERATED EXCERPT
Please rate it.

When observed under a microscope, the nucleus within the cells can either present as open phase nucleus or a closed phase nucleus... Open phase nucleus is also called as vesicular nucleus... It can exhibit marked variation in size and shape, occasionally with very large and bizarre forms... Usually no more than 2-3 nucleoli per cell are seen... In such cells, the nucleolus can be seen only during interphase... The most prominent substructure within the nucleus is the nucleolus... The ribosomal proteins are then transported from the cytoplasm to the nucleolus, where they are assembled with rRNAs to form pre-ribosomal particles... However, in a cell that is actively synthesizing proteins and possesses increased amounts of pre-ribosomal particles (protein factories), the nucleoli are positively charged and may stain amphophilic to eosinophilic owing to their very high protein content... The importance of ribosomal production is particularly evident in oocytes and actively growing mammalian cells in which the rRNA genes are amplified to support the synthesis of large number of ribosomes required to meet the need for protein synthesis... In cancerous cells, the cell's entry into cell cycle is always associated with up-regulation of the nucleolar function and increased nucleolar size, which is directly dependent on the rapidity of cell cycle proliferation... As the amount of pre-ribosomal proteins increase in these cancerous cells, they may exhibit amphophilic to eosinophilic nucleoli upon staining with hematoxylin and eosin stain... Few lesions/pathologies where eosinophilic nuclei can be encountered include: Classical Reed-Sternberg cells: The hallmark of Hodgkin's lymphoma is characterized by bilobed or multinucleated nucleus with prominent eosinophilic inclusions-like nucleoli resembling an “owl's eye” Malignant melanoma Myeloid sarcoma Carcinoid tumors Colon carcinoma Ewing's sarcoma Peripheral neuroectodermal tumor Rhabdomyosarcoma Olfactory neuroblastoma Nephroblastoma or Wilms’ tumor Poorly differentiated squamous cell carcinoma Anaplastic carcinoma... The cells were of varied morphology ranging from spindle to ovoid to epitheliod... They exhibited cellular and nuclear pleomorphism; increased mitoses and were almost completely devoid of melanin pigmentation... Most of the tumor cells showed the presence of eosinophilic nucleoli representing an actively synthesizing cell, which aided in arriving at a diagnosis of malignant melanoma.

No MeSH data available.


Related in: MedlinePlus