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Eosinophilic nucleoli.

Bavle RM - J Oral Maxillofac Pathol (2014)

View Article: PubMed Central - PubMed

Affiliation: Editor-in-Chief-JOMFP, Department of Oral and Maxillofacial Pathology, Krishnadevaraya College of Dental Sciences, Bangalore - 562 157, Karnataka, India. E-mail: rad.iaomp@gmail.com.

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When observed under a microscope, the nucleus within the cells can either present as open phase nucleus or a closed phase nucleus... Open phase nucleus is also called as vesicular nucleus... It can exhibit marked variation in size and shape, occasionally with very large and bizarre forms... Usually no more than 2-3 nucleoli per cell are seen... In such cells, the nucleolus can be seen only during interphase... The most prominent substructure within the nucleus is the nucleolus... It is a dense non-membrane bound structure observed during interphase in a normal cell, because it dissipates during cell division... The nucleolus is the site of rRNA synthesis, transcription and processing... The ribosomal proteins are then transported from the cytoplasm to the nucleolus, where they are assembled with rRNAs to form pre-ribosomal particles... However, in a cell that is actively synthesizing proteins and possesses increased amounts of pre-ribosomal particles (protein factories), the nucleoli are positively charged and may stain amphophilic to eosinophilic owing to their very high protein content... As the amount of pre-ribosomal proteins increase in these cancerous cells, they may exhibit amphophilic to eosinophilic nucleoli upon staining with hematoxylin and eosin stain... Classical Reed-Sternberg cells: The hallmark of Hodgkin's lymphoma is characterized by bilobed or multinucleated nucleus with prominent eosinophilic inclusions-like nucleoli resembling an “owl's eye” Malignant melanoma Myeloid sarcoma Carcinoid tumors Colon carcinoma Ewing's sarcoma Peripheral neuroectodermal tumor Rhabdomyosarcoma Olfactory neuroblastoma Nephroblastoma or Wilms’ tumor Poorly differentiated squamous cell carcinoma Anaplastic carcinoma... Microscopically, the lesion presented as a highly cellular pleomorphic tumor with the tumor cells arranged in the form of fascicles, pseudo-organoid and storiform pattern... The cells were of varied morphology ranging from spindle to ovoid to epitheliod... Most of the tumor cells showed the presence of eosinophilic nucleoli representing an actively synthesizing cell, which aided in arriving at a diagnosis of malignant melanoma.

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(a) Photomicrograph shows tumor cells with ill-defined cell borders, abundant cytoplasm and open phase nucleus with prominent eosinophilic nucleoli (H&E stain, ×400). (b) Hand-drawn illustration of the same
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Figure 1: (a) Photomicrograph shows tumor cells with ill-defined cell borders, abundant cytoplasm and open phase nucleus with prominent eosinophilic nucleoli (H&E stain, ×400). (b) Hand-drawn illustration of the same

Mentions: A high-power view of the tumor cells along with a hand-drawn illustration of the lesion is presented in Figure 1. The H and E stained images of the tumor cells is presented in Figure 2.


Eosinophilic nucleoli.

Bavle RM - J Oral Maxillofac Pathol (2014)

(a) Photomicrograph shows tumor cells with ill-defined cell borders, abundant cytoplasm and open phase nucleus with prominent eosinophilic nucleoli (H&E stain, ×400). (b) Hand-drawn illustration of the same
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4196279&req=5

Figure 1: (a) Photomicrograph shows tumor cells with ill-defined cell borders, abundant cytoplasm and open phase nucleus with prominent eosinophilic nucleoli (H&E stain, ×400). (b) Hand-drawn illustration of the same
Mentions: A high-power view of the tumor cells along with a hand-drawn illustration of the lesion is presented in Figure 1. The H and E stained images of the tumor cells is presented in Figure 2.

View Article: PubMed Central - PubMed

Affiliation: Editor-in-Chief-JOMFP, Department of Oral and Maxillofacial Pathology, Krishnadevaraya College of Dental Sciences, Bangalore - 562 157, Karnataka, India. E-mail: rad.iaomp@gmail.com.

AUTOMATICALLY GENERATED EXCERPT
Please rate it.

When observed under a microscope, the nucleus within the cells can either present as open phase nucleus or a closed phase nucleus... Open phase nucleus is also called as vesicular nucleus... It can exhibit marked variation in size and shape, occasionally with very large and bizarre forms... Usually no more than 2-3 nucleoli per cell are seen... In such cells, the nucleolus can be seen only during interphase... The most prominent substructure within the nucleus is the nucleolus... It is a dense non-membrane bound structure observed during interphase in a normal cell, because it dissipates during cell division... The nucleolus is the site of rRNA synthesis, transcription and processing... The ribosomal proteins are then transported from the cytoplasm to the nucleolus, where they are assembled with rRNAs to form pre-ribosomal particles... However, in a cell that is actively synthesizing proteins and possesses increased amounts of pre-ribosomal particles (protein factories), the nucleoli are positively charged and may stain amphophilic to eosinophilic owing to their very high protein content... As the amount of pre-ribosomal proteins increase in these cancerous cells, they may exhibit amphophilic to eosinophilic nucleoli upon staining with hematoxylin and eosin stain... Classical Reed-Sternberg cells: The hallmark of Hodgkin's lymphoma is characterized by bilobed or multinucleated nucleus with prominent eosinophilic inclusions-like nucleoli resembling an “owl's eye” Malignant melanoma Myeloid sarcoma Carcinoid tumors Colon carcinoma Ewing's sarcoma Peripheral neuroectodermal tumor Rhabdomyosarcoma Olfactory neuroblastoma Nephroblastoma or Wilms’ tumor Poorly differentiated squamous cell carcinoma Anaplastic carcinoma... Microscopically, the lesion presented as a highly cellular pleomorphic tumor with the tumor cells arranged in the form of fascicles, pseudo-organoid and storiform pattern... The cells were of varied morphology ranging from spindle to ovoid to epitheliod... Most of the tumor cells showed the presence of eosinophilic nucleoli representing an actively synthesizing cell, which aided in arriving at a diagnosis of malignant melanoma.

No MeSH data available.


Related in: MedlinePlus