Absence of patient-to-patient intrahospital transmission of Staphylococcus aureus as determined by whole-genome sequencing.
Bottom Line: To identify patient-to-patient intrahospital transmission using high-resolution genetic analysis, we sequenced the genomes of a consecutive set of 398 S. aureus isolates from sterile-site infections.The S. aureus strains were collected from four hospitals in the Houston Methodist Hospital System over a 6-month period.In addition, our data demonstrate that highly related pools of S. aureus strains exist in the community which may complicate outbreak investigations.
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Mentions: S. aureus CC75 is a highly genetically divergent lineage that has been reported only in Australia, Cambodia, and South America (39–42). Unexpectedly, our Houston data set included three isolates that clustered with CC75, thus representing the first report of these organisms in North America. Interestingly, our three CC75 isolates are phylogenetically divergent (17,002 to 20,915 SNPs) from the only available CC75 reference genome, MSHR1132 (Fig. 5) (39). Consequently, these newly identified clones may represent the emergence of a novel clonal complex in North America.