Metagenome-wide association of microbial determinants of host phenotype in Drosophila melanogaster.
Bottom Line: The effects of monoassociation on host traits were not confined to particular taxonomic groups.This analysis showed significant effects of pyrroloquinoline quinone biosynthesis genes on development time, confirming the results of a published transposon mutagenesis screen, thereby validating the MGWA; it also identified multiple genes predicted to affect host TAG content, including extracellular glucose oxidation pathway components.The genomes of the chosen bacterial strains were previously sequenced, so we could statistically associate specific bacterial genes with bacterially mediated reduction in host fat content.
Affiliation: Department of Entomology, Cornell University, Ithaca, New York, USA firstname.lastname@example.org.Show MeSH
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Affiliation: Department of Entomology, Cornell University, Ithaca, New York, USA email@example.com.