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The effect of perinatal anxiety on bronchiolitis is influenced by polymorphisms in ROS-related genes.

Lee E, Chang HY, Lee KS, Suh DI, Yu HS, Kang MJ, Choi IA, Park J, Kim KW, Shin YH, Ahn KM, Kwon JY, Choi SJ, Lee KJ, Won HS, Yang SI, Jung YH, Kim HY, Seo JH, Kwon JW, Kim BJ, Kim HB, Lee SY, Kim EJ, Lee JS, Keyes KM, Shin YJ, Hong SJ, COCOA study gro - BMC Pulm Med (2014)

Bottom Line: Copy number variations of GSTT1 were measured by real-time polymerase chain reaction.In infants with the TC + CC genotype of CD14, high levels of perinatal anxiety were associated with an increased risk of upper RTI, lower RTI, and bronchiolitis (aOR 2.51, 4.60, and 4.31, respectively).The effect of perinatal anxiety on the occurrence of bronchiolitis during infancy was influenced by genetic polymorphisms in antioxidant defense and innate immunity genes.

View Article: PubMed Central - PubMed

Affiliation: Department of Pediatrics, Childhood Asthma Atopy Center, Research Center for Standardization of Allergic Diseases, Asan Medical Center, University of Ulsan College of Medicine, 88 Olympic-ro 43-gil, Songpa-gu, Seoul 138-736, Korea. yjshin@yuhs.ac.

ABSTRACT

Background: Exposure to perinatal anxiety affects disease susceptibility in offspring but studies on the association between perinatal anxiety and gene polymorphisms are lacking. This study aimed to elucidate the interaction between perinatal anxiety and polymorphisms in antioxidant defense and innate immunity genes on the development of respiratory tract infections (RTIs) during early infancy.

Methods: Trait anxiety levels in 440 women were assessed by the State-Trait Anxiety Inventory during late gestation. The occurrence of RTIs, including bronchiolitis, during the first year of life was assessed by parent-reported doctor diagnosis. Polymorphisms in glutathione S-transferase P-1 (GSTP1, rs1695) and CD14 (rs2569190) were genotyped using the TaqMan assay. Copy number variations of GSTT1 were measured by real-time polymerase chain reaction.

Results: Exposure to high levels of perinatal anxiety increased the risk of bronchiolitis in the first year of life (adjusted odds ratio [aOR], 1.30; 95% confidence interval [CI]: 1.00-1.80), in particular among children with the AG + GG genotype of GSTP1 or the GSTT1 genotype (aOR 3.36 and 2.79). In infants with the TC + CC genotype of CD14, high levels of perinatal anxiety were associated with an increased risk of upper RTI, lower RTI, and bronchiolitis (aOR 2.51, 4.60, and 4.31, respectively).

Conclusions: Perinatal maternal anxiety levels affect the occurrence of bronchiolitis in offspring. The effect of perinatal anxiety on the occurrence of bronchiolitis during infancy was influenced by genetic polymorphisms in antioxidant defense and innate immunity genes.

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Related in: MedlinePlus

Relationship between perinatal maternal anxiety levels and predicted probability of bronchiolitis at 1 year of age.
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Fig1: Relationship between perinatal maternal anxiety levels and predicted probability of bronchiolitis at 1 year of age.

Mentions: High levels of perinatal maternal anxiety were associated with an increased risk of LRTIs, especially bronchiolitis, but not with total URTIs (Table 2). For a 1 SD increase in STAI score, the odds of LRTI risk during the first year of life increased by 1.35 times (95% CI: 1.01–1.78). The crude association between perinatal anxiety levels and the development of bronchiolitis was weakly significant (OR 1.35, 95% CI: 1.00–1.81; adjusted OR [aOR] 1.30, 95% CI: 1.00–1.80). However, perinatal anxiety did not increase the risk of URTIs (aOR 1.10, 95% CI: 0.87–1.39). In addition, high levels of perinatal maternal anxiety were not significantly associated with the occurrence of other subtypes of RTIs except bronchiolitis. Figure 1 represents the predicted probability of bronchiolitis at 1 year of age for each observed value of perinatal anxiety score in the multivariate model.Table 2


The effect of perinatal anxiety on bronchiolitis is influenced by polymorphisms in ROS-related genes.

Lee E, Chang HY, Lee KS, Suh DI, Yu HS, Kang MJ, Choi IA, Park J, Kim KW, Shin YH, Ahn KM, Kwon JY, Choi SJ, Lee KJ, Won HS, Yang SI, Jung YH, Kim HY, Seo JH, Kwon JW, Kim BJ, Kim HB, Lee SY, Kim EJ, Lee JS, Keyes KM, Shin YJ, Hong SJ, COCOA study gro - BMC Pulm Med (2014)

Relationship between perinatal maternal anxiety levels and predicted probability of bronchiolitis at 1 year of age.
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4196140&req=5

Fig1: Relationship between perinatal maternal anxiety levels and predicted probability of bronchiolitis at 1 year of age.
Mentions: High levels of perinatal maternal anxiety were associated with an increased risk of LRTIs, especially bronchiolitis, but not with total URTIs (Table 2). For a 1 SD increase in STAI score, the odds of LRTI risk during the first year of life increased by 1.35 times (95% CI: 1.01–1.78). The crude association between perinatal anxiety levels and the development of bronchiolitis was weakly significant (OR 1.35, 95% CI: 1.00–1.81; adjusted OR [aOR] 1.30, 95% CI: 1.00–1.80). However, perinatal anxiety did not increase the risk of URTIs (aOR 1.10, 95% CI: 0.87–1.39). In addition, high levels of perinatal maternal anxiety were not significantly associated with the occurrence of other subtypes of RTIs except bronchiolitis. Figure 1 represents the predicted probability of bronchiolitis at 1 year of age for each observed value of perinatal anxiety score in the multivariate model.Table 2

Bottom Line: Copy number variations of GSTT1 were measured by real-time polymerase chain reaction.In infants with the TC + CC genotype of CD14, high levels of perinatal anxiety were associated with an increased risk of upper RTI, lower RTI, and bronchiolitis (aOR 2.51, 4.60, and 4.31, respectively).The effect of perinatal anxiety on the occurrence of bronchiolitis during infancy was influenced by genetic polymorphisms in antioxidant defense and innate immunity genes.

View Article: PubMed Central - PubMed

Affiliation: Department of Pediatrics, Childhood Asthma Atopy Center, Research Center for Standardization of Allergic Diseases, Asan Medical Center, University of Ulsan College of Medicine, 88 Olympic-ro 43-gil, Songpa-gu, Seoul 138-736, Korea. yjshin@yuhs.ac.

ABSTRACT

Background: Exposure to perinatal anxiety affects disease susceptibility in offspring but studies on the association between perinatal anxiety and gene polymorphisms are lacking. This study aimed to elucidate the interaction between perinatal anxiety and polymorphisms in antioxidant defense and innate immunity genes on the development of respiratory tract infections (RTIs) during early infancy.

Methods: Trait anxiety levels in 440 women were assessed by the State-Trait Anxiety Inventory during late gestation. The occurrence of RTIs, including bronchiolitis, during the first year of life was assessed by parent-reported doctor diagnosis. Polymorphisms in glutathione S-transferase P-1 (GSTP1, rs1695) and CD14 (rs2569190) were genotyped using the TaqMan assay. Copy number variations of GSTT1 were measured by real-time polymerase chain reaction.

Results: Exposure to high levels of perinatal anxiety increased the risk of bronchiolitis in the first year of life (adjusted odds ratio [aOR], 1.30; 95% confidence interval [CI]: 1.00-1.80), in particular among children with the AG + GG genotype of GSTP1 or the GSTT1 genotype (aOR 3.36 and 2.79). In infants with the TC + CC genotype of CD14, high levels of perinatal anxiety were associated with an increased risk of upper RTI, lower RTI, and bronchiolitis (aOR 2.51, 4.60, and 4.31, respectively).

Conclusions: Perinatal maternal anxiety levels affect the occurrence of bronchiolitis in offspring. The effect of perinatal anxiety on the occurrence of bronchiolitis during infancy was influenced by genetic polymorphisms in antioxidant defense and innate immunity genes.

Show MeSH
Related in: MedlinePlus