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Sleep complaints in adolescent depression: one year naturalistic follow-up study.

Urrila AS, Karlsson L, Kiviruusu O, Pankakoski M, Pelkonen M, Strandholm T, Marttunen M, Adolescent Depression Study gro - BMC Psychiatry (2014)

Bottom Line: All sleep complaints were less frequent at one-year follow-up compared to baseline.Baseline sleep complaints did not adversely affect clinical outcome at one-year follow-up: severity of the sleep complaints at baseline was associated with a steeper improvement of depressive and anxiety symptoms, suicidality/self-harm symptoms, and overall psychosocial functioning over time.Our results suggest that sleep disturbances at baseline do not necessarily lead to poorer clinical outcome during follow-up.

View Article: PubMed Central - PubMed

ABSTRACT

Background: Sleep complaints are highly prevalent in adolescents suffering from major depressive disorder (MDD). The aims of this study were to describe the longitudinal course of sleep complaints, and to assess the association between sleep complaints and clinical outcome in a sample of adolescents with MDD during naturalistic follow-up.

Methods: A sample of adolescent outpatients (n = 166; age 13-19 years, 17.5% boys) diagnosed with MDD was followed-up during one year in naturalistic settings. Sleep symptoms and psychiatric symptoms were assessed with interviews and self-report questionnaires.

Results: All sleep complaints were less frequent at one-year follow-up compared to baseline. Baseline sleep complaints did not adversely affect clinical outcome at one-year follow-up: severity of the sleep complaints at baseline was associated with a steeper improvement of depressive and anxiety symptoms, suicidality/self-harm symptoms, and overall psychosocial functioning over time.

Conclusions: Our results suggest that sleep disturbances at baseline do not necessarily lead to poorer clinical outcome during follow-up. Larger longitudinal studies combining both subjective and objective measures of sleep in depressed adolescents are needed to clarify the link between sleep and depression further.

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Related in: MedlinePlus

BDI-21 total scores (sleep item excluded) during the follow-up period up to 400 days. Black dots indicate subjects with a sleep complaint severity score of 6–9 (n = 52), blue dots indicate subjects with a sleep complaint severity score of 10–13 (n = 83), and red dots indicate the subjects with a sleep complaint severity score of 14–18 (n = 31) at baseline interview. Loess curves with respective colours are fitted for each of these sleep subgroups.
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Fig2: BDI-21 total scores (sleep item excluded) during the follow-up period up to 400 days. Black dots indicate subjects with a sleep complaint severity score of 6–9 (n = 52), blue dots indicate subjects with a sleep complaint severity score of 10–13 (n = 83), and red dots indicate the subjects with a sleep complaint severity score of 14–18 (n = 31) at baseline interview. Loess curves with respective colours are fitted for each of these sleep subgroups.

Mentions: To assess the recovery process in more detail, the effects of baseline sleep complaint severity on the changes in the repeated BDI-21 measurement scores during the follow-up period were assessed with a GEE-model. Age and gender were controlled; female gender was associated with higher BDI-21 scores, while age showed no significant effect. Sleep complaint severity score at baseline showed a major effect on BDI-21 score. An interaction between time and sleep complaint severity score was observed (β = −0.003, SE = 0.0012, p = 0.028), indicating a significantly steeper decline in depression symptom severity over time in adolescents with higher sleep complaint severity score (Figure 2).Figure 2


Sleep complaints in adolescent depression: one year naturalistic follow-up study.

Urrila AS, Karlsson L, Kiviruusu O, Pankakoski M, Pelkonen M, Strandholm T, Marttunen M, Adolescent Depression Study gro - BMC Psychiatry (2014)

BDI-21 total scores (sleep item excluded) during the follow-up period up to 400 days. Black dots indicate subjects with a sleep complaint severity score of 6–9 (n = 52), blue dots indicate subjects with a sleep complaint severity score of 10–13 (n = 83), and red dots indicate the subjects with a sleep complaint severity score of 14–18 (n = 31) at baseline interview. Loess curves with respective colours are fitted for each of these sleep subgroups.
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4196090&req=5

Fig2: BDI-21 total scores (sleep item excluded) during the follow-up period up to 400 days. Black dots indicate subjects with a sleep complaint severity score of 6–9 (n = 52), blue dots indicate subjects with a sleep complaint severity score of 10–13 (n = 83), and red dots indicate the subjects with a sleep complaint severity score of 14–18 (n = 31) at baseline interview. Loess curves with respective colours are fitted for each of these sleep subgroups.
Mentions: To assess the recovery process in more detail, the effects of baseline sleep complaint severity on the changes in the repeated BDI-21 measurement scores during the follow-up period were assessed with a GEE-model. Age and gender were controlled; female gender was associated with higher BDI-21 scores, while age showed no significant effect. Sleep complaint severity score at baseline showed a major effect on BDI-21 score. An interaction between time and sleep complaint severity score was observed (β = −0.003, SE = 0.0012, p = 0.028), indicating a significantly steeper decline in depression symptom severity over time in adolescents with higher sleep complaint severity score (Figure 2).Figure 2

Bottom Line: All sleep complaints were less frequent at one-year follow-up compared to baseline.Baseline sleep complaints did not adversely affect clinical outcome at one-year follow-up: severity of the sleep complaints at baseline was associated with a steeper improvement of depressive and anxiety symptoms, suicidality/self-harm symptoms, and overall psychosocial functioning over time.Our results suggest that sleep disturbances at baseline do not necessarily lead to poorer clinical outcome during follow-up.

View Article: PubMed Central - PubMed

ABSTRACT

Background: Sleep complaints are highly prevalent in adolescents suffering from major depressive disorder (MDD). The aims of this study were to describe the longitudinal course of sleep complaints, and to assess the association between sleep complaints and clinical outcome in a sample of adolescents with MDD during naturalistic follow-up.

Methods: A sample of adolescent outpatients (n = 166; age 13-19 years, 17.5% boys) diagnosed with MDD was followed-up during one year in naturalistic settings. Sleep symptoms and psychiatric symptoms were assessed with interviews and self-report questionnaires.

Results: All sleep complaints were less frequent at one-year follow-up compared to baseline. Baseline sleep complaints did not adversely affect clinical outcome at one-year follow-up: severity of the sleep complaints at baseline was associated with a steeper improvement of depressive and anxiety symptoms, suicidality/self-harm symptoms, and overall psychosocial functioning over time.

Conclusions: Our results suggest that sleep disturbances at baseline do not necessarily lead to poorer clinical outcome during follow-up. Larger longitudinal studies combining both subjective and objective measures of sleep in depressed adolescents are needed to clarify the link between sleep and depression further.

Show MeSH
Related in: MedlinePlus