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Different efficacy of EGFR tyrosine kinase inhibitors and prognosis in patients with subtypes of EGFR-mutated advanced non-small cell lung cancer: a meta-analysis.

Wang H, Huang J, Yu X, Han S, Yan X, Sun S, Zhu X - J. Cancer Res. Clin. Oncol. (2014)

Bottom Line: In addition, we used variance analysis for the progression-free survival data (PFS) and used the rank sum test for the overall survival data.The PFS (MD 3.55; 95 % CI 0.90-6.20; P = 0.009; MD 2.57; 95 % CI 0.51-4.62; P = 0.01) and overall survival (OS) (MD 10.52; 95 % CI 5.10-15.93; P = 0.0001) of the 19del mutation group were significantly longer than the 21L858R mutation group; the same results were observed in the variance analysis and rank sum test.Furthermore, patients with the 19del mutation have both a longer PFS and OS.

View Article: PubMed Central - PubMed

Affiliation: Medical School of Southeast University, Nanjing, China. Zhongda Hospital of Southeast University, Dingjiaqiao 87,Gulou District, Nanjing 210009, China

ABSTRACT

Background: Nearly 85 % of lung-cancer-specific epidermal growth factor receptor (EGFR) sensitive mutations comprise a substitution at position 858 (21L858R) and deletion mutants in exon 19 (19del). The aim of this study was to assess the role of EGFR mutation subtypes in predicting the efficacy of EGFR tyrosine kinase inhibitors (EGFR TKIs) and the prognosis of patients with advanced non-small cell lung cancer (NSCLC).

Method: We systematically searched for eligible articles investigating the association between EGFR mutation subtypes and the efficacy of EGFR TKIs and the prognosis of patients with NSCLC. The summary risk ratio (RR) and mean difference (MD) were calculated using meta-analysis. In addition, we used variance analysis for the progression-free survival data (PFS) and used the rank sum test for the overall survival data.

Results: We identified 22 eligible trials involving 1,082 patients. The objective response rate of the 19del mutation group was significantly higher than the 21L858R mutation group (RR 1.23; 95 % CI 1.12-1.36; P < 0.0001). The PFS (MD 3.55; 95 % CI 0.90-6.20; P = 0.009; MD 2.57; 95 % CI 0.51-4.62; P = 0.01) and overall survival (OS) (MD 10.52; 95 % CI 5.10-15.93; P = 0.0001) of the 19del mutation group were significantly longer than the 21L858R mutation group; the same results were observed in the variance analysis and rank sum test.

Conclusion: The 19del mutation may be a more efficient clinical marker for predicting the response of patients with NSCLC to EGFR TKIs. Furthermore, patients with the 19del mutation have both a longer PFS and OS. The 19del mutation is also the prognostic factor for patients with NSCLC.

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Related in: MedlinePlus

Electronic search flow chart
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Related In: Results  -  Collection


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Fig1: Electronic search flow chart

Mentions: As shown in the NSCLC flow chart (Fig. 1), our initial search yielded 950 potentially relevant published articles. A review of the titles and abstracts of these articles resulted in 145 promising articles. These remaining 145 articles were selected for analysis and evaluated in greater detail by reviewing the full articles. After exclusion of the studies that did not meet the inclusion criteria, 22 studies with 1,082 patients were included in the meta-analysis, 593 patients with the exon 19del mutation and 489 patients with the exon 21L858R mutation. The characteristics of the eligible studies are summarized in Table 1.Fig. 1


Different efficacy of EGFR tyrosine kinase inhibitors and prognosis in patients with subtypes of EGFR-mutated advanced non-small cell lung cancer: a meta-analysis.

Wang H, Huang J, Yu X, Han S, Yan X, Sun S, Zhu X - J. Cancer Res. Clin. Oncol. (2014)

Electronic search flow chart
© Copyright Policy - OpenAccess
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4196046&req=5

Fig1: Electronic search flow chart
Mentions: As shown in the NSCLC flow chart (Fig. 1), our initial search yielded 950 potentially relevant published articles. A review of the titles and abstracts of these articles resulted in 145 promising articles. These remaining 145 articles were selected for analysis and evaluated in greater detail by reviewing the full articles. After exclusion of the studies that did not meet the inclusion criteria, 22 studies with 1,082 patients were included in the meta-analysis, 593 patients with the exon 19del mutation and 489 patients with the exon 21L858R mutation. The characteristics of the eligible studies are summarized in Table 1.Fig. 1

Bottom Line: In addition, we used variance analysis for the progression-free survival data (PFS) and used the rank sum test for the overall survival data.The PFS (MD 3.55; 95 % CI 0.90-6.20; P = 0.009; MD 2.57; 95 % CI 0.51-4.62; P = 0.01) and overall survival (OS) (MD 10.52; 95 % CI 5.10-15.93; P = 0.0001) of the 19del mutation group were significantly longer than the 21L858R mutation group; the same results were observed in the variance analysis and rank sum test.Furthermore, patients with the 19del mutation have both a longer PFS and OS.

View Article: PubMed Central - PubMed

Affiliation: Medical School of Southeast University, Nanjing, China. Zhongda Hospital of Southeast University, Dingjiaqiao 87,Gulou District, Nanjing 210009, China

ABSTRACT

Background: Nearly 85 % of lung-cancer-specific epidermal growth factor receptor (EGFR) sensitive mutations comprise a substitution at position 858 (21L858R) and deletion mutants in exon 19 (19del). The aim of this study was to assess the role of EGFR mutation subtypes in predicting the efficacy of EGFR tyrosine kinase inhibitors (EGFR TKIs) and the prognosis of patients with advanced non-small cell lung cancer (NSCLC).

Method: We systematically searched for eligible articles investigating the association between EGFR mutation subtypes and the efficacy of EGFR TKIs and the prognosis of patients with NSCLC. The summary risk ratio (RR) and mean difference (MD) were calculated using meta-analysis. In addition, we used variance analysis for the progression-free survival data (PFS) and used the rank sum test for the overall survival data.

Results: We identified 22 eligible trials involving 1,082 patients. The objective response rate of the 19del mutation group was significantly higher than the 21L858R mutation group (RR 1.23; 95 % CI 1.12-1.36; P < 0.0001). The PFS (MD 3.55; 95 % CI 0.90-6.20; P = 0.009; MD 2.57; 95 % CI 0.51-4.62; P = 0.01) and overall survival (OS) (MD 10.52; 95 % CI 5.10-15.93; P = 0.0001) of the 19del mutation group were significantly longer than the 21L858R mutation group; the same results were observed in the variance analysis and rank sum test.

Conclusion: The 19del mutation may be a more efficient clinical marker for predicting the response of patients with NSCLC to EGFR TKIs. Furthermore, patients with the 19del mutation have both a longer PFS and OS. The 19del mutation is also the prognostic factor for patients with NSCLC.

Show MeSH
Related in: MedlinePlus