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The neutrophil protein S100A12 is associated with a comprehensive ultrasonographic synovitis score in a longitudinal study of patients with rheumatoid arthritis treated with adalimumab.

Nordal HH, Brun JG, Halse AK, Jonsson R, Fagerhol MK, Hammer HB - BMC Musculoskelet Disord (2014)

Bottom Line: The concentrations of S100A12 decreased after 3 months (p < 0.01) and significant correlations were found between S100A12 and the other laboratory markers during follow-up (0.50-0.62, p < 0.05).Compared with CRP and ESR, S100A12 showed higher correlations with the sum US scores (both BM and PD), with median (range) correlation coefficients of 0.55 (0.35-0.78 (NS-p < 0.001)) for sum BM scores and 0.45 (0.27-0.75 (NS-p < 0.001)) for sum PD scores.The S100A12 protein was significantly associated with other inflammatory markers, clinical assessments as well as sum US scores, indicating that S100A12 is a potential marker of inflammation in RA patients.

View Article: PubMed Central - PubMed

Affiliation: Broegelmann Research Laboratory, Department of Clinical Science, University of Bergen, Postboks 7804, N-5020 Bergen, Norway. Hilde.Nordal@k2.uib.no.

ABSTRACT

Background: The calcium-binding protein S100A12 correlates with measures of disease activity in patients with rheumatoid arthritis (RA). The protein reflects neutrophil activation and the present objective was to explore in a pilot study the associations between S100A12 and other inflammatory markers, clinical assessments as well as degree of synovitis detected by a comprehensive ultrasonography (US) examination in RA patients during biologic treatment.

Methods: Twenty patients with RA were examined clinically and by use of US as well as laboratory markers S100A12, calprotectin, C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) before starting adalimumab, with follow-up after 1, 3, 6 and 12 months. Ultrasonographic B-mode (BM) and power Doppler (PD) assessments of 78 joints, 36 tendons/tendon groups and 2 bursas were performed, and sum US scores calculated. Wilcoxon signed rank test assessed treatment response and Spearman rank correlation test was used to calculate correlations.

Results: The concentrations of S100A12 decreased after 3 months (p < 0.01) and significant correlations were found between S100A12 and the other laboratory markers during follow-up (0.50-0.62, p < 0.05). Of the clinical assessments, S100A12 had highest correlations with the assessor's global VAS (0.46-0.85, p < 0.05). Compared with CRP and ESR, S100A12 showed higher correlations with the sum US scores (both BM and PD), with median (range) correlation coefficients of 0.55 (0.35-0.78 (NS-p < 0.001)) for sum BM scores and 0.45 (0.27-0.75 (NS-p < 0.001)) for sum PD scores.

Conclusions: The S100A12 protein was significantly associated with other inflammatory markers, clinical assessments as well as sum US scores, indicating that S100A12 is a potential marker of inflammation in RA patients.

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Related in: MedlinePlus

Median levels (interquartile range) of the inflammatory markers and ultrasonographic scores during 12 months follow-up. a) Concentrations of S100A12. b) Concentrations of C-reactive protein (CRP). c) Erythrocyte sedimentation rates (ESRs). d) B-mode (BM) sum scores. e) Power Doppler (PD) sum scores. *Significantly decreased levels from baseline, p<0.01.
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Fig1: Median levels (interquartile range) of the inflammatory markers and ultrasonographic scores during 12 months follow-up. a) Concentrations of S100A12. b) Concentrations of C-reactive protein (CRP). c) Erythrocyte sedimentation rates (ESRs). d) B-mode (BM) sum scores. e) Power Doppler (PD) sum scores. *Significantly decreased levels from baseline, p<0.01.

Mentions: The patients had median (range) S100A12 levels of 49 (18 to 475) ng/mL at baseline, 34 (18 to 687) ng/mL after 1 month, 23 (16 to 173) ng/mL after 3 months, 33 (19 to 394) ng/mL after 6 months and 40 (12 to 620) ng/mL after 12 months. The level of S100A12, ESR and CRP changed significantly from baseline to 3 months follow-up and ESR already after 1 month, while the sum US scores decreased significantly during follow-up (Figure 1).Figure 1


The neutrophil protein S100A12 is associated with a comprehensive ultrasonographic synovitis score in a longitudinal study of patients with rheumatoid arthritis treated with adalimumab.

Nordal HH, Brun JG, Halse AK, Jonsson R, Fagerhol MK, Hammer HB - BMC Musculoskelet Disord (2014)

Median levels (interquartile range) of the inflammatory markers and ultrasonographic scores during 12 months follow-up. a) Concentrations of S100A12. b) Concentrations of C-reactive protein (CRP). c) Erythrocyte sedimentation rates (ESRs). d) B-mode (BM) sum scores. e) Power Doppler (PD) sum scores. *Significantly decreased levels from baseline, p<0.01.
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4196044&req=5

Fig1: Median levels (interquartile range) of the inflammatory markers and ultrasonographic scores during 12 months follow-up. a) Concentrations of S100A12. b) Concentrations of C-reactive protein (CRP). c) Erythrocyte sedimentation rates (ESRs). d) B-mode (BM) sum scores. e) Power Doppler (PD) sum scores. *Significantly decreased levels from baseline, p<0.01.
Mentions: The patients had median (range) S100A12 levels of 49 (18 to 475) ng/mL at baseline, 34 (18 to 687) ng/mL after 1 month, 23 (16 to 173) ng/mL after 3 months, 33 (19 to 394) ng/mL after 6 months and 40 (12 to 620) ng/mL after 12 months. The level of S100A12, ESR and CRP changed significantly from baseline to 3 months follow-up and ESR already after 1 month, while the sum US scores decreased significantly during follow-up (Figure 1).Figure 1

Bottom Line: The concentrations of S100A12 decreased after 3 months (p < 0.01) and significant correlations were found between S100A12 and the other laboratory markers during follow-up (0.50-0.62, p < 0.05).Compared with CRP and ESR, S100A12 showed higher correlations with the sum US scores (both BM and PD), with median (range) correlation coefficients of 0.55 (0.35-0.78 (NS-p < 0.001)) for sum BM scores and 0.45 (0.27-0.75 (NS-p < 0.001)) for sum PD scores.The S100A12 protein was significantly associated with other inflammatory markers, clinical assessments as well as sum US scores, indicating that S100A12 is a potential marker of inflammation in RA patients.

View Article: PubMed Central - PubMed

Affiliation: Broegelmann Research Laboratory, Department of Clinical Science, University of Bergen, Postboks 7804, N-5020 Bergen, Norway. Hilde.Nordal@k2.uib.no.

ABSTRACT

Background: The calcium-binding protein S100A12 correlates with measures of disease activity in patients with rheumatoid arthritis (RA). The protein reflects neutrophil activation and the present objective was to explore in a pilot study the associations between S100A12 and other inflammatory markers, clinical assessments as well as degree of synovitis detected by a comprehensive ultrasonography (US) examination in RA patients during biologic treatment.

Methods: Twenty patients with RA were examined clinically and by use of US as well as laboratory markers S100A12, calprotectin, C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) before starting adalimumab, with follow-up after 1, 3, 6 and 12 months. Ultrasonographic B-mode (BM) and power Doppler (PD) assessments of 78 joints, 36 tendons/tendon groups and 2 bursas were performed, and sum US scores calculated. Wilcoxon signed rank test assessed treatment response and Spearman rank correlation test was used to calculate correlations.

Results: The concentrations of S100A12 decreased after 3 months (p < 0.01) and significant correlations were found between S100A12 and the other laboratory markers during follow-up (0.50-0.62, p < 0.05). Of the clinical assessments, S100A12 had highest correlations with the assessor's global VAS (0.46-0.85, p < 0.05). Compared with CRP and ESR, S100A12 showed higher correlations with the sum US scores (both BM and PD), with median (range) correlation coefficients of 0.55 (0.35-0.78 (NS-p < 0.001)) for sum BM scores and 0.45 (0.27-0.75 (NS-p < 0.001)) for sum PD scores.

Conclusions: The S100A12 protein was significantly associated with other inflammatory markers, clinical assessments as well as sum US scores, indicating that S100A12 is a potential marker of inflammation in RA patients.

Show MeSH
Related in: MedlinePlus