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Association between Catechol-O-methyltransferase rs4680 (G>A) polymorphism and lung cancer risk.

Tan X, Chen M - Diagn Pathol (2014)

Bottom Line: Two major public databases (Pubmed and Embase) and several Chinese databases were searched for eligible studies.Pooled odds ratios (OR) and 95% confidence intervals (CI) were calculated to estimate the strength of the association.GG, OR=1.190, 95% CI=1.001-1.422, p=0.049).

View Article: PubMed Central - PubMed

Affiliation: Department of Cardiothoracic Surgery, First Affiliated Hospital, Guangxi Medical University, Nanning, Guangxi, China. chen535@126.com.

ABSTRACT

Background: The association between the Val158Met polymorphism in the catechol-O-methyltransferase (COMT) gene and lung cancer risk remains controversial and inconclusive. Therefore, the meta-analysis was performed to provide a quality reevaluation of the association between the COMT Val158Met polymorphism and the risk of lung cancer.

Methods: Two major public databases (Pubmed and Embase) and several Chinese databases were searched for eligible studies. Pooled odds ratios (OR) and 95% confidence intervals (CI) were calculated to estimate the strength of the association.

Results: Five publications, including six individual studies with a total of 4,043 subjects (1,796 cases and 2,247 controls) regarding the association of COMT Val158Met polymorphism with lung cancer susceptibility were included in this meta-analysis. Overall, pooled analysis indicated that there was no significant association between COMT Val158Met polymorphism and lung cancer susceptibility under all genetic models. Likewise, no association was observed in the stratified analysis by ethnicity and control source, either. However, Val158Met polymorphism was shown to increase lung cancer risk among women (AG vs. GG, OR=1.190, 95% CI=1.001-1.422, p=0.049).

Conclusion: These findings suggested that the COMT l58Val/Met polymorphism confer genetic susceptibility to lung cancer among women. However, no evidence was found for the association with lung cancer risk in ethnicity and smoking status.

Virtual slides: The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/13000_2014_192.

No MeSH data available.


Related in: MedlinePlus

Forest plots of COMT Val158Met polymorphism and lung cancer in the overall analysis using the fixed-effect dominant model (AG vs. GG).
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Fig2: Forest plots of COMT Val158Met polymorphism and lung cancer in the overall analysis using the fixed-effect dominant model (AG vs. GG).

Mentions: The meta-analysis results on the association between COMT Val158Met polymorphism and the risk of lung cancer are shown in Table 2. When between-study heterogeneity was significant, the random-effects model was performed in our analysis; otherwise, fixed-effects model was adopted used. By pooling eligible studies together, the results derived from random-effect models indicated that variant allele (A) of COMT Val158Met was not associated with lung cancer (A vs. G, OR = 1.052, 95% CI = 0.837–1.322, p = 0.664). Similarly, no significant associations were observed under all other genetic models (homogenous: AA vs. GG, OR = 1.088,95% CI = 0.677–1.749, p = 0.729; heterogeneous: AG vs. GG, OR = 1.107, 95% CI = 0.962–1.275, p = 0.157; dominant: AA/AG vs. GG, OR = 1.085, 95% CI = 0.867–1.357, p = 0.477; recessive: AA vs. AG/GG, OR = 1.037, 95% CI = 0.686–1.568, p = 0.863) (Table 2, Figure 2).Table 2


Association between Catechol-O-methyltransferase rs4680 (G>A) polymorphism and lung cancer risk.

Tan X, Chen M - Diagn Pathol (2014)

Forest plots of COMT Val158Met polymorphism and lung cancer in the overall analysis using the fixed-effect dominant model (AG vs. GG).
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4196007&req=5

Fig2: Forest plots of COMT Val158Met polymorphism and lung cancer in the overall analysis using the fixed-effect dominant model (AG vs. GG).
Mentions: The meta-analysis results on the association between COMT Val158Met polymorphism and the risk of lung cancer are shown in Table 2. When between-study heterogeneity was significant, the random-effects model was performed in our analysis; otherwise, fixed-effects model was adopted used. By pooling eligible studies together, the results derived from random-effect models indicated that variant allele (A) of COMT Val158Met was not associated with lung cancer (A vs. G, OR = 1.052, 95% CI = 0.837–1.322, p = 0.664). Similarly, no significant associations were observed under all other genetic models (homogenous: AA vs. GG, OR = 1.088,95% CI = 0.677–1.749, p = 0.729; heterogeneous: AG vs. GG, OR = 1.107, 95% CI = 0.962–1.275, p = 0.157; dominant: AA/AG vs. GG, OR = 1.085, 95% CI = 0.867–1.357, p = 0.477; recessive: AA vs. AG/GG, OR = 1.037, 95% CI = 0.686–1.568, p = 0.863) (Table 2, Figure 2).Table 2

Bottom Line: Two major public databases (Pubmed and Embase) and several Chinese databases were searched for eligible studies.Pooled odds ratios (OR) and 95% confidence intervals (CI) were calculated to estimate the strength of the association.GG, OR=1.190, 95% CI=1.001-1.422, p=0.049).

View Article: PubMed Central - PubMed

Affiliation: Department of Cardiothoracic Surgery, First Affiliated Hospital, Guangxi Medical University, Nanning, Guangxi, China. chen535@126.com.

ABSTRACT

Background: The association between the Val158Met polymorphism in the catechol-O-methyltransferase (COMT) gene and lung cancer risk remains controversial and inconclusive. Therefore, the meta-analysis was performed to provide a quality reevaluation of the association between the COMT Val158Met polymorphism and the risk of lung cancer.

Methods: Two major public databases (Pubmed and Embase) and several Chinese databases were searched for eligible studies. Pooled odds ratios (OR) and 95% confidence intervals (CI) were calculated to estimate the strength of the association.

Results: Five publications, including six individual studies with a total of 4,043 subjects (1,796 cases and 2,247 controls) regarding the association of COMT Val158Met polymorphism with lung cancer susceptibility were included in this meta-analysis. Overall, pooled analysis indicated that there was no significant association between COMT Val158Met polymorphism and lung cancer susceptibility under all genetic models. Likewise, no association was observed in the stratified analysis by ethnicity and control source, either. However, Val158Met polymorphism was shown to increase lung cancer risk among women (AG vs. GG, OR=1.190, 95% CI=1.001-1.422, p=0.049).

Conclusion: These findings suggested that the COMT l58Val/Met polymorphism confer genetic susceptibility to lung cancer among women. However, no evidence was found for the association with lung cancer risk in ethnicity and smoking status.

Virtual slides: The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/13000_2014_192.

No MeSH data available.


Related in: MedlinePlus