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Preoperative diagnostic for periprosthetic joint infection prior to total knee revision arthroplasty.

Claassen L, Radtke K, Ettinger M, Plaass C, von Lewinski G - Orthop Rev (Pavia) (2014)

Bottom Line: The diagnostic aspiration had a specificity of 0.87, a sensitivity of 0.39, a positive predictive value of 0.67 and a negative predictive value of 0.68.For C-reactive protein the specificity was 0.61 and the sensitivity was 0.48, the serum white blood cell count had a specificity of 0.98 and a sensitivity of 0.23.Our data queries whether diagnostic joint aspiration or serum inflammatory markers are sufficient to verify or exclude a PJI.

View Article: PubMed Central - PubMed

Affiliation: Orthopedic Department, Hannover Medical School , Germany.

ABSTRACT
Periprosthetic joint infection (PJI) after total knee arthroplasty remains a challenging problem. The aim of this study was to evaluate the accuracy of diagnostic knee aspiration and serum inflammatory markers in diagnostic of a PJI after total knee arthroplasty. Within 2011 and 2012, 46 patients received a one- or two-stage revision arthroplasty of the knee joint. These patients received a total number of 77 operations. A preoperative aspiration was performed in each case. We analyzed the microbiological and histological examinations of the samples from the aspiration and from the revision operation and additionally estimated serum inflammatory markers. The diagnostic aspiration had a specificity of 0.87, a sensitivity of 0.39, a positive predictive value of 0.67 and a negative predictive value of 0.68. For C-reactive protein the specificity was 0.61 and the sensitivity was 0.48, the serum white blood cell count had a specificity of 0.98 and a sensitivity of 0.23. Our data queries whether diagnostic joint aspiration or serum inflammatory markers are sufficient to verify or exclude a PJI.

No MeSH data available.


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Serum white blood cell had high values for specificity and the positive predictive value.
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fig003: Serum white blood cell had high values for specificity and the positive predictive value.

Mentions: The serum WBC was elevated in 7 cases. In 90 cases the serum WBC was normal. The threshold was 10 thousand for female and 9.1 thousand for male. The sensitivity of the serum WBC for detecting an ongoing infection was 0.23 (0.1-0.4), the specificity 0.98 (0.88-1.0), the positive predictive value 0.88 (0.47-1.0) and the negative predictive value 0.65 (0.53-0.76) (Figure 3).


Preoperative diagnostic for periprosthetic joint infection prior to total knee revision arthroplasty.

Claassen L, Radtke K, Ettinger M, Plaass C, von Lewinski G - Orthop Rev (Pavia) (2014)

Serum white blood cell had high values for specificity and the positive predictive value.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4195990&req=5

fig003: Serum white blood cell had high values for specificity and the positive predictive value.
Mentions: The serum WBC was elevated in 7 cases. In 90 cases the serum WBC was normal. The threshold was 10 thousand for female and 9.1 thousand for male. The sensitivity of the serum WBC for detecting an ongoing infection was 0.23 (0.1-0.4), the specificity 0.98 (0.88-1.0), the positive predictive value 0.88 (0.47-1.0) and the negative predictive value 0.65 (0.53-0.76) (Figure 3).

Bottom Line: The diagnostic aspiration had a specificity of 0.87, a sensitivity of 0.39, a positive predictive value of 0.67 and a negative predictive value of 0.68.For C-reactive protein the specificity was 0.61 and the sensitivity was 0.48, the serum white blood cell count had a specificity of 0.98 and a sensitivity of 0.23.Our data queries whether diagnostic joint aspiration or serum inflammatory markers are sufficient to verify or exclude a PJI.

View Article: PubMed Central - PubMed

Affiliation: Orthopedic Department, Hannover Medical School , Germany.

ABSTRACT
Periprosthetic joint infection (PJI) after total knee arthroplasty remains a challenging problem. The aim of this study was to evaluate the accuracy of diagnostic knee aspiration and serum inflammatory markers in diagnostic of a PJI after total knee arthroplasty. Within 2011 and 2012, 46 patients received a one- or two-stage revision arthroplasty of the knee joint. These patients received a total number of 77 operations. A preoperative aspiration was performed in each case. We analyzed the microbiological and histological examinations of the samples from the aspiration and from the revision operation and additionally estimated serum inflammatory markers. The diagnostic aspiration had a specificity of 0.87, a sensitivity of 0.39, a positive predictive value of 0.67 and a negative predictive value of 0.68. For C-reactive protein the specificity was 0.61 and the sensitivity was 0.48, the serum white blood cell count had a specificity of 0.98 and a sensitivity of 0.23. Our data queries whether diagnostic joint aspiration or serum inflammatory markers are sufficient to verify or exclude a PJI.

No MeSH data available.


Related in: MedlinePlus