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Does intra articular platelet rich plasma injection improve function, pain and quality of life in patients with osteoarthritis of the knee? A randomized clinical trial.

Rayegani SM, Raeissadat SA, Taheri MS, Babaee M, Bahrami MH, Eliaspour D, Ghorbani E - Orthop Rev (Pavia) (2014)

Bottom Line: Thirty-one patients in the PRP group and 31 patients in the control group were studied.Mean changes of total WOMAC, physical component summery and mental component summery of Short Form-36 in PRP group showed better improvement than control group (P<0.05).This study showed that intra articular PRP knee injection combined with therapeutic exercise can be more effective in pain reduction and improvement of stiffness and quality of life, compared with therapeutic exercise alone.

View Article: PubMed Central - PubMed

Affiliation: Physical Medicine and Rehabilitation Department, Shohada-e-Tajrish Hospital , Tehran, Iran.

ABSTRACT
We designed a randomized clinical trial with control group, to investigate the effects of platelet rich plasma (PRP) on pain, stiffness, function and quality of life in patients with knee osteoarthritis. Patients were randomly divided in two groups. For both groups of participants, therapeutic exercise was prescribed. In the PRP group, two courses of leukocyte rich PRP (5.6 fold higher platelet concentration) with a 4-week interval was injected. For each participant, Western Ontario and McMaster University's Arthritis Index (WOMAC) and the SF-36 questionnaire (Farsi version) were filled at the baseline and 6 months after treatments. Thirty-one patients in the PRP group and 31 patients in the control group were studied. Mean changes of total WOMAC, physical component summery and mental component summery of Short Form-36 in PRP group showed better improvement than control group (P<0.05). This study showed that intra articular PRP knee injection combined with therapeutic exercise can be more effective in pain reduction and improvement of stiffness and quality of life, compared with therapeutic exercise alone.

No MeSH data available.


Related in: MedlinePlus

A) Score changes of WOMAC between 2 groups. B) SF-36 test: pre and post-treatment for the physical health domain in both groups. C) SF-36 test: pre and post-treatment for the mental health domain in both groups. Statistical between and inter-group difference was observed (P<0.05). Blue lines: values at baseline; green lines: values after 6 months.
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fig002: A) Score changes of WOMAC between 2 groups. B) SF-36 test: pre and post-treatment for the physical health domain in both groups. C) SF-36 test: pre and post-treatment for the mental health domain in both groups. Statistical between and inter-group difference was observed (P<0.05). Blue lines: values at baseline; green lines: values after 6 months.

Mentions: Mean total WOMAC score from base to 6 months follow up improved in the two groups with a P=0.01 (Figure 2A). Also mean total WOMAC changes between the two groups had a significant difference with P=0.03 (Figure 2A). Changes of all 3 WOMAC parameters in the two groups showed improvements. The mean difference of WOMAC subgroups between the two groups was significant only for pain (P<0.05) Table 3.


Does intra articular platelet rich plasma injection improve function, pain and quality of life in patients with osteoarthritis of the knee? A randomized clinical trial.

Rayegani SM, Raeissadat SA, Taheri MS, Babaee M, Bahrami MH, Eliaspour D, Ghorbani E - Orthop Rev (Pavia) (2014)

A) Score changes of WOMAC between 2 groups. B) SF-36 test: pre and post-treatment for the physical health domain in both groups. C) SF-36 test: pre and post-treatment for the mental health domain in both groups. Statistical between and inter-group difference was observed (P<0.05). Blue lines: values at baseline; green lines: values after 6 months.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4195987&req=5

fig002: A) Score changes of WOMAC between 2 groups. B) SF-36 test: pre and post-treatment for the physical health domain in both groups. C) SF-36 test: pre and post-treatment for the mental health domain in both groups. Statistical between and inter-group difference was observed (P<0.05). Blue lines: values at baseline; green lines: values after 6 months.
Mentions: Mean total WOMAC score from base to 6 months follow up improved in the two groups with a P=0.01 (Figure 2A). Also mean total WOMAC changes between the two groups had a significant difference with P=0.03 (Figure 2A). Changes of all 3 WOMAC parameters in the two groups showed improvements. The mean difference of WOMAC subgroups between the two groups was significant only for pain (P<0.05) Table 3.

Bottom Line: Thirty-one patients in the PRP group and 31 patients in the control group were studied.Mean changes of total WOMAC, physical component summery and mental component summery of Short Form-36 in PRP group showed better improvement than control group (P<0.05).This study showed that intra articular PRP knee injection combined with therapeutic exercise can be more effective in pain reduction and improvement of stiffness and quality of life, compared with therapeutic exercise alone.

View Article: PubMed Central - PubMed

Affiliation: Physical Medicine and Rehabilitation Department, Shohada-e-Tajrish Hospital , Tehran, Iran.

ABSTRACT
We designed a randomized clinical trial with control group, to investigate the effects of platelet rich plasma (PRP) on pain, stiffness, function and quality of life in patients with knee osteoarthritis. Patients were randomly divided in two groups. For both groups of participants, therapeutic exercise was prescribed. In the PRP group, two courses of leukocyte rich PRP (5.6 fold higher platelet concentration) with a 4-week interval was injected. For each participant, Western Ontario and McMaster University's Arthritis Index (WOMAC) and the SF-36 questionnaire (Farsi version) were filled at the baseline and 6 months after treatments. Thirty-one patients in the PRP group and 31 patients in the control group were studied. Mean changes of total WOMAC, physical component summery and mental component summery of Short Form-36 in PRP group showed better improvement than control group (P<0.05). This study showed that intra articular PRP knee injection combined with therapeutic exercise can be more effective in pain reduction and improvement of stiffness and quality of life, compared with therapeutic exercise alone.

No MeSH data available.


Related in: MedlinePlus