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Does intra articular platelet rich plasma injection improve function, pain and quality of life in patients with osteoarthritis of the knee? A randomized clinical trial.

Rayegani SM, Raeissadat SA, Taheri MS, Babaee M, Bahrami MH, Eliaspour D, Ghorbani E - Orthop Rev (Pavia) (2014)

Bottom Line: Thirty-one patients in the PRP group and 31 patients in the control group were studied.Mean changes of total WOMAC, physical component summery and mental component summery of Short Form-36 in PRP group showed better improvement than control group (P<0.05).This study showed that intra articular PRP knee injection combined with therapeutic exercise can be more effective in pain reduction and improvement of stiffness and quality of life, compared with therapeutic exercise alone.

View Article: PubMed Central - PubMed

Affiliation: Physical Medicine and Rehabilitation Department, Shohada-e-Tajrish Hospital , Tehran, Iran.

ABSTRACT
We designed a randomized clinical trial with control group, to investigate the effects of platelet rich plasma (PRP) on pain, stiffness, function and quality of life in patients with knee osteoarthritis. Patients were randomly divided in two groups. For both groups of participants, therapeutic exercise was prescribed. In the PRP group, two courses of leukocyte rich PRP (5.6 fold higher platelet concentration) with a 4-week interval was injected. For each participant, Western Ontario and McMaster University's Arthritis Index (WOMAC) and the SF-36 questionnaire (Farsi version) were filled at the baseline and 6 months after treatments. Thirty-one patients in the PRP group and 31 patients in the control group were studied. Mean changes of total WOMAC, physical component summery and mental component summery of Short Form-36 in PRP group showed better improvement than control group (P<0.05). This study showed that intra articular PRP knee injection combined with therapeutic exercise can be more effective in pain reduction and improvement of stiffness and quality of life, compared with therapeutic exercise alone.

No MeSH data available.


Related in: MedlinePlus

Consort flow diagram.
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Related In: Results  -  Collection

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fig001: Consort flow diagram.

Mentions: In this study, 31 patients in the PRP group and 31 patients in the control group were finally investigated. The mean age of the patients was 56.19±10 and the mean BMI 27.77±3.61. Characteristics of the two groups are presented in Table 1. Figure 1 shows the consort flow diagram.


Does intra articular platelet rich plasma injection improve function, pain and quality of life in patients with osteoarthritis of the knee? A randomized clinical trial.

Rayegani SM, Raeissadat SA, Taheri MS, Babaee M, Bahrami MH, Eliaspour D, Ghorbani E - Orthop Rev (Pavia) (2014)

Consort flow diagram.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4195987&req=5

fig001: Consort flow diagram.
Mentions: In this study, 31 patients in the PRP group and 31 patients in the control group were finally investigated. The mean age of the patients was 56.19±10 and the mean BMI 27.77±3.61. Characteristics of the two groups are presented in Table 1. Figure 1 shows the consort flow diagram.

Bottom Line: Thirty-one patients in the PRP group and 31 patients in the control group were studied.Mean changes of total WOMAC, physical component summery and mental component summery of Short Form-36 in PRP group showed better improvement than control group (P<0.05).This study showed that intra articular PRP knee injection combined with therapeutic exercise can be more effective in pain reduction and improvement of stiffness and quality of life, compared with therapeutic exercise alone.

View Article: PubMed Central - PubMed

Affiliation: Physical Medicine and Rehabilitation Department, Shohada-e-Tajrish Hospital , Tehran, Iran.

ABSTRACT
We designed a randomized clinical trial with control group, to investigate the effects of platelet rich plasma (PRP) on pain, stiffness, function and quality of life in patients with knee osteoarthritis. Patients were randomly divided in two groups. For both groups of participants, therapeutic exercise was prescribed. In the PRP group, two courses of leukocyte rich PRP (5.6 fold higher platelet concentration) with a 4-week interval was injected. For each participant, Western Ontario and McMaster University's Arthritis Index (WOMAC) and the SF-36 questionnaire (Farsi version) were filled at the baseline and 6 months after treatments. Thirty-one patients in the PRP group and 31 patients in the control group were studied. Mean changes of total WOMAC, physical component summery and mental component summery of Short Form-36 in PRP group showed better improvement than control group (P<0.05). This study showed that intra articular PRP knee injection combined with therapeutic exercise can be more effective in pain reduction and improvement of stiffness and quality of life, compared with therapeutic exercise alone.

No MeSH data available.


Related in: MedlinePlus