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Western Eurasian ancestry in modern Siberians based on mitogenomic data.

Derenko M, Malyarchuk B, Denisova G, Perkova M, Litvinov A, Grzybowski T, Dambueva I, Skonieczna K, Rogalla U, Tsybovsky I, Zakharov I - BMC Evol. Biol. (2014)

Bottom Line: From a survey of 158 western Eurasian mtDNA genomes found in Siberia we estimate that nearly 40% of them most likely have western Asian and another 29% European ancestry.It is striking that 65 of northern Asian mitogenomes, i.e. ~41%, fall into 19 branches and subclades which can be considered as Siberian-specific being found so far only in Siberian populations.We have not found the modern northern Asians to have western Eurasian genetic components of sufficient antiquity to indicate traces of pre-LGM expansions.

View Article: PubMed Central - PubMed

Affiliation: Institute of Biological Problems of the North, Russian Academy of Sciences, Magadan, Russia. mderenko@mail.ru.

ABSTRACT

Background: Although the genetic heritage of aboriginal Siberians is mostly of eastern Asian ancestry, a substantial western Eurasian component is observed in the majority of northern Asian populations. Traces of at least two migrations into southern Siberia, one from eastern Europe and the other from western Asia/the Caucasus have been detected previously in mitochondrial gene pools of modern Siberians.

Results: We report here 166 new complete mitochondrial DNA (mtDNA) sequences that allow us to expand and re-analyze the available data sets of western Eurasian lineages found in northern Asian populations, define the phylogenetic status of Siberian-specific subclades and search for links between mtDNA haplotypes/subclades and events of human migrations. From a survey of 158 western Eurasian mtDNA genomes found in Siberia we estimate that nearly 40% of them most likely have western Asian and another 29% European ancestry. It is striking that 65 of northern Asian mitogenomes, i.e. ~41%, fall into 19 branches and subclades which can be considered as Siberian-specific being found so far only in Siberian populations. From the coalescence analysis it is evident that the sequence divergence of Siberian-specific subclades was relatively small, corresponding to only 0.6-9.5 kya (using the complete mtDNA rate) and 1-6 kya (coding region rate).

Conclusions: The phylogeographic analysis implies that the western Eurasian founders, giving rise to Siberian specific subclades, may trace their ancestry only to the early and mid-Holocene, though some of genetic lineages may trace their ancestry back to the end of Last Glacial Maximum (LGM). We have not found the modern northern Asians to have western Eurasian genetic components of sufficient antiquity to indicate traces of pre-LGM expansions.

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Related in: MedlinePlus

Phylogenetic tree of haplogroup H8. Numbers along links refer to substitutions scored relative to rCRS [47]. Transversions are further specified; ins and del denote insertions and deletions of nucleotides, respectively; symbol < denotes parallel mutations, back mutations are underlined. Time estimates (in kya) shown along links next to clade labels are based on the complete mtDNA genome clock (given with 95% CI and marked in blue) and the coding region clock (given with the associated standard error and marked in red). Established haplogroup labels are shown in black; red are newly identified haplogroups in the present study.
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Fig2: Phylogenetic tree of haplogroup H8. Numbers along links refer to substitutions scored relative to rCRS [47]. Transversions are further specified; ins and del denote insertions and deletions of nucleotides, respectively; symbol < denotes parallel mutations, back mutations are underlined. Time estimates (in kya) shown along links next to clade labels are based on the complete mtDNA genome clock (given with 95% CI and marked in blue) and the coding region clock (given with the associated standard error and marked in red). Established haplogroup labels are shown in black; red are newly identified haplogroups in the present study.

Mentions: Another haplogroup, H8b1 is also found solely in Siberians, and it falls into two distinct sub-clades, H8b1a and H8b1b, with almost the same coalescence age estimated as 0–3.5 kya and 1.3-3 kya, respectively (Figure 2). If we regard H8 as potentially having a Near Eastern and Caucasus source (as has been suggested in [39] based on the mtDNA hypervariable region 1 (HVS 1) variability data), we may assume that H8b1 might have arose in situ in southern Siberia after the arrival of the H8b1 founder from somewhere else in the Near East/Caucasus region.Figure 2


Western Eurasian ancestry in modern Siberians based on mitogenomic data.

Derenko M, Malyarchuk B, Denisova G, Perkova M, Litvinov A, Grzybowski T, Dambueva I, Skonieczna K, Rogalla U, Tsybovsky I, Zakharov I - BMC Evol. Biol. (2014)

Phylogenetic tree of haplogroup H8. Numbers along links refer to substitutions scored relative to rCRS [47]. Transversions are further specified; ins and del denote insertions and deletions of nucleotides, respectively; symbol < denotes parallel mutations, back mutations are underlined. Time estimates (in kya) shown along links next to clade labels are based on the complete mtDNA genome clock (given with 95% CI and marked in blue) and the coding region clock (given with the associated standard error and marked in red). Established haplogroup labels are shown in black; red are newly identified haplogroups in the present study.
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4195960&req=5

Fig2: Phylogenetic tree of haplogroup H8. Numbers along links refer to substitutions scored relative to rCRS [47]. Transversions are further specified; ins and del denote insertions and deletions of nucleotides, respectively; symbol < denotes parallel mutations, back mutations are underlined. Time estimates (in kya) shown along links next to clade labels are based on the complete mtDNA genome clock (given with 95% CI and marked in blue) and the coding region clock (given with the associated standard error and marked in red). Established haplogroup labels are shown in black; red are newly identified haplogroups in the present study.
Mentions: Another haplogroup, H8b1 is also found solely in Siberians, and it falls into two distinct sub-clades, H8b1a and H8b1b, with almost the same coalescence age estimated as 0–3.5 kya and 1.3-3 kya, respectively (Figure 2). If we regard H8 as potentially having a Near Eastern and Caucasus source (as has been suggested in [39] based on the mtDNA hypervariable region 1 (HVS 1) variability data), we may assume that H8b1 might have arose in situ in southern Siberia after the arrival of the H8b1 founder from somewhere else in the Near East/Caucasus region.Figure 2

Bottom Line: From a survey of 158 western Eurasian mtDNA genomes found in Siberia we estimate that nearly 40% of them most likely have western Asian and another 29% European ancestry.It is striking that 65 of northern Asian mitogenomes, i.e. ~41%, fall into 19 branches and subclades which can be considered as Siberian-specific being found so far only in Siberian populations.We have not found the modern northern Asians to have western Eurasian genetic components of sufficient antiquity to indicate traces of pre-LGM expansions.

View Article: PubMed Central - PubMed

Affiliation: Institute of Biological Problems of the North, Russian Academy of Sciences, Magadan, Russia. mderenko@mail.ru.

ABSTRACT

Background: Although the genetic heritage of aboriginal Siberians is mostly of eastern Asian ancestry, a substantial western Eurasian component is observed in the majority of northern Asian populations. Traces of at least two migrations into southern Siberia, one from eastern Europe and the other from western Asia/the Caucasus have been detected previously in mitochondrial gene pools of modern Siberians.

Results: We report here 166 new complete mitochondrial DNA (mtDNA) sequences that allow us to expand and re-analyze the available data sets of western Eurasian lineages found in northern Asian populations, define the phylogenetic status of Siberian-specific subclades and search for links between mtDNA haplotypes/subclades and events of human migrations. From a survey of 158 western Eurasian mtDNA genomes found in Siberia we estimate that nearly 40% of them most likely have western Asian and another 29% European ancestry. It is striking that 65 of northern Asian mitogenomes, i.e. ~41%, fall into 19 branches and subclades which can be considered as Siberian-specific being found so far only in Siberian populations. From the coalescence analysis it is evident that the sequence divergence of Siberian-specific subclades was relatively small, corresponding to only 0.6-9.5 kya (using the complete mtDNA rate) and 1-6 kya (coding region rate).

Conclusions: The phylogeographic analysis implies that the western Eurasian founders, giving rise to Siberian specific subclades, may trace their ancestry only to the early and mid-Holocene, though some of genetic lineages may trace their ancestry back to the end of Last Glacial Maximum (LGM). We have not found the modern northern Asians to have western Eurasian genetic components of sufficient antiquity to indicate traces of pre-LGM expansions.

Show MeSH
Related in: MedlinePlus