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Western Eurasian ancestry in modern Siberians based on mitogenomic data.

Derenko M, Malyarchuk B, Denisova G, Perkova M, Litvinov A, Grzybowski T, Dambueva I, Skonieczna K, Rogalla U, Tsybovsky I, Zakharov I - BMC Evol. Biol. (2014)

Bottom Line: From a survey of 158 western Eurasian mtDNA genomes found in Siberia we estimate that nearly 40% of them most likely have western Asian and another 29% European ancestry.It is striking that 65 of northern Asian mitogenomes, i.e. ~41%, fall into 19 branches and subclades which can be considered as Siberian-specific being found so far only in Siberian populations.We have not found the modern northern Asians to have western Eurasian genetic components of sufficient antiquity to indicate traces of pre-LGM expansions.

View Article: PubMed Central - PubMed

Affiliation: Institute of Biological Problems of the North, Russian Academy of Sciences, Magadan, Russia. mderenko@mail.ru.

ABSTRACT

Background: Although the genetic heritage of aboriginal Siberians is mostly of eastern Asian ancestry, a substantial western Eurasian component is observed in the majority of northern Asian populations. Traces of at least two migrations into southern Siberia, one from eastern Europe and the other from western Asia/the Caucasus have been detected previously in mitochondrial gene pools of modern Siberians.

Results: We report here 166 new complete mitochondrial DNA (mtDNA) sequences that allow us to expand and re-analyze the available data sets of western Eurasian lineages found in northern Asian populations, define the phylogenetic status of Siberian-specific subclades and search for links between mtDNA haplotypes/subclades and events of human migrations. From a survey of 158 western Eurasian mtDNA genomes found in Siberia we estimate that nearly 40% of them most likely have western Asian and another 29% European ancestry. It is striking that 65 of northern Asian mitogenomes, i.e. ~41%, fall into 19 branches and subclades which can be considered as Siberian-specific being found so far only in Siberian populations. From the coalescence analysis it is evident that the sequence divergence of Siberian-specific subclades was relatively small, corresponding to only 0.6-9.5 kya (using the complete mtDNA rate) and 1-6 kya (coding region rate).

Conclusions: The phylogeographic analysis implies that the western Eurasian founders, giving rise to Siberian specific subclades, may trace their ancestry only to the early and mid-Holocene, though some of genetic lineages may trace their ancestry back to the end of Last Glacial Maximum (LGM). We have not found the modern northern Asians to have western Eurasian genetic components of sufficient antiquity to indicate traces of pre-LGM expansions.

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Related in: MedlinePlus

Phylogenetic tree of haplogroup K1a17. Numbers along links refer to substitutions scored relative to rCRS [47], back mutation is underlined. Time estimates (in kya) shown along links next to clade labels are based on the complete mtDNA genome clock (given with 95% CI and marked in blue) and the coding region clock (given with the associated standard error and marked in red). Redefined haplogroup label is shown in blue; red are newly identified haplogroups in the present study.
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Fig1: Phylogenetic tree of haplogroup K1a17. Numbers along links refer to substitutions scored relative to rCRS [47], back mutation is underlined. Time estimates (in kya) shown along links next to clade labels are based on the complete mtDNA genome clock (given with 95% CI and marked in blue) and the coding region clock (given with the associated standard error and marked in red). Redefined haplogroup label is shown in blue; red are newly identified haplogroups in the present study.

Mentions: Clade U8a phylogeny demonstrates that our Buryat individual together with eastern Europeans (Russians, Finns and Swedes) belongs to subclade U8a1a1b1. The addition of Polish mtDNA (P14) to the tree gives a new branching point for U8a2, defined now by transitions at nps 827 and 1700. Most surprisingly, by analyzing Siberian K sequences in the context of published Eurasian mtDNAs, we found eight subclades including five new - K1a17b, K1a3b, K1a32, K1b2a2b and K2a5b, two of which (K1a17b and K1a32) seem to be Siberian-specific, being found so far only in Buryats and Khamnigans (FigureĀ 1, Additional file 5).Figure 1


Western Eurasian ancestry in modern Siberians based on mitogenomic data.

Derenko M, Malyarchuk B, Denisova G, Perkova M, Litvinov A, Grzybowski T, Dambueva I, Skonieczna K, Rogalla U, Tsybovsky I, Zakharov I - BMC Evol. Biol. (2014)

Phylogenetic tree of haplogroup K1a17. Numbers along links refer to substitutions scored relative to rCRS [47], back mutation is underlined. Time estimates (in kya) shown along links next to clade labels are based on the complete mtDNA genome clock (given with 95% CI and marked in blue) and the coding region clock (given with the associated standard error and marked in red). Redefined haplogroup label is shown in blue; red are newly identified haplogroups in the present study.
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4195960&req=5

Fig1: Phylogenetic tree of haplogroup K1a17. Numbers along links refer to substitutions scored relative to rCRS [47], back mutation is underlined. Time estimates (in kya) shown along links next to clade labels are based on the complete mtDNA genome clock (given with 95% CI and marked in blue) and the coding region clock (given with the associated standard error and marked in red). Redefined haplogroup label is shown in blue; red are newly identified haplogroups in the present study.
Mentions: Clade U8a phylogeny demonstrates that our Buryat individual together with eastern Europeans (Russians, Finns and Swedes) belongs to subclade U8a1a1b1. The addition of Polish mtDNA (P14) to the tree gives a new branching point for U8a2, defined now by transitions at nps 827 and 1700. Most surprisingly, by analyzing Siberian K sequences in the context of published Eurasian mtDNAs, we found eight subclades including five new - K1a17b, K1a3b, K1a32, K1b2a2b and K2a5b, two of which (K1a17b and K1a32) seem to be Siberian-specific, being found so far only in Buryats and Khamnigans (FigureĀ 1, Additional file 5).Figure 1

Bottom Line: From a survey of 158 western Eurasian mtDNA genomes found in Siberia we estimate that nearly 40% of them most likely have western Asian and another 29% European ancestry.It is striking that 65 of northern Asian mitogenomes, i.e. ~41%, fall into 19 branches and subclades which can be considered as Siberian-specific being found so far only in Siberian populations.We have not found the modern northern Asians to have western Eurasian genetic components of sufficient antiquity to indicate traces of pre-LGM expansions.

View Article: PubMed Central - PubMed

Affiliation: Institute of Biological Problems of the North, Russian Academy of Sciences, Magadan, Russia. mderenko@mail.ru.

ABSTRACT

Background: Although the genetic heritage of aboriginal Siberians is mostly of eastern Asian ancestry, a substantial western Eurasian component is observed in the majority of northern Asian populations. Traces of at least two migrations into southern Siberia, one from eastern Europe and the other from western Asia/the Caucasus have been detected previously in mitochondrial gene pools of modern Siberians.

Results: We report here 166 new complete mitochondrial DNA (mtDNA) sequences that allow us to expand and re-analyze the available data sets of western Eurasian lineages found in northern Asian populations, define the phylogenetic status of Siberian-specific subclades and search for links between mtDNA haplotypes/subclades and events of human migrations. From a survey of 158 western Eurasian mtDNA genomes found in Siberia we estimate that nearly 40% of them most likely have western Asian and another 29% European ancestry. It is striking that 65 of northern Asian mitogenomes, i.e. ~41%, fall into 19 branches and subclades which can be considered as Siberian-specific being found so far only in Siberian populations. From the coalescence analysis it is evident that the sequence divergence of Siberian-specific subclades was relatively small, corresponding to only 0.6-9.5 kya (using the complete mtDNA rate) and 1-6 kya (coding region rate).

Conclusions: The phylogeographic analysis implies that the western Eurasian founders, giving rise to Siberian specific subclades, may trace their ancestry only to the early and mid-Holocene, though some of genetic lineages may trace their ancestry back to the end of Last Glacial Maximum (LGM). We have not found the modern northern Asians to have western Eurasian genetic components of sufficient antiquity to indicate traces of pre-LGM expansions.

Show MeSH
Related in: MedlinePlus