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The relation between neutrophil-to-lymphocyte ratio and coronary chronic total occlusions.

Demir K, Avci A, Altunkeser BB, Yilmaz A, Keles F, Ersecgin A - BMC Cardiovasc Disord (2014)

Bottom Line: NLR was compared in the three groups.NLR levels were significantly higher in the CTO than in the other two groups (p < 0.001).Bivariate correlation analysis showed a positive correlation between NLR and SYNTAX Score, and multivariate logistic regression analysis found that NLR was an independent predictor of CTO.

View Article: PubMed Central - PubMed

Affiliation: Faculty of Medicine Cardiology Department, Selcuk University, 42075 Konya, Turkey. drkenan76@yahoo.com.

ABSTRACT

Background: Neutrophil-to-lymphocyte ratio (NLR) is a marker of systemic inflammation that correlates with cardiac events. This study assessed the association between NLR and the presence of chronic coronary total occlusion (CTO).

Methods: The study population included 225 patients, a control group (n = 75), a coronary artery disease group (n = 75), and a CTO group (n = 75). NLR was compared in the three groups.

Results: NLR levels were significantly higher in the CTO than in the other two groups (p < 0.001). Bivariate correlation analysis showed a positive correlation between NLR and SYNTAX Score, and multivariate logistic regression analysis found that NLR was an independent predictor of CTO. ROC analysis showed that an NLR cut-off of 2.09 could distinguish between patients with and without CTO (AUC = 0.74; 95% CI, 0.68-0.81), with a specificity of 69.3% and a sensitivity of 61%.

Conclusion: NLR may be useful as a marker of CTO.

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Related in: MedlinePlus

Receiver–operating characteristic analysis and curve for predicting coronary total occlusions (CTOs).
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Fig4: Receiver–operating characteristic analysis and curve for predicting coronary total occlusions (CTOs).

Mentions: In ROC analysis, a cut point of 2.09 for NLR was identified in patients with CTO (area under the curve = 0.74; 95% CI, 0.68-0.81). A NLR value of more than 2.09 demonstrated a specificity of 69.3% and a sensitivity of 61% (Figure 4).Table 2


The relation between neutrophil-to-lymphocyte ratio and coronary chronic total occlusions.

Demir K, Avci A, Altunkeser BB, Yilmaz A, Keles F, Ersecgin A - BMC Cardiovasc Disord (2014)

Receiver–operating characteristic analysis and curve for predicting coronary total occlusions (CTOs).
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4195893&req=5

Fig4: Receiver–operating characteristic analysis and curve for predicting coronary total occlusions (CTOs).
Mentions: In ROC analysis, a cut point of 2.09 for NLR was identified in patients with CTO (area under the curve = 0.74; 95% CI, 0.68-0.81). A NLR value of more than 2.09 demonstrated a specificity of 69.3% and a sensitivity of 61% (Figure 4).Table 2

Bottom Line: NLR was compared in the three groups.NLR levels were significantly higher in the CTO than in the other two groups (p < 0.001).Bivariate correlation analysis showed a positive correlation between NLR and SYNTAX Score, and multivariate logistic regression analysis found that NLR was an independent predictor of CTO.

View Article: PubMed Central - PubMed

Affiliation: Faculty of Medicine Cardiology Department, Selcuk University, 42075 Konya, Turkey. drkenan76@yahoo.com.

ABSTRACT

Background: Neutrophil-to-lymphocyte ratio (NLR) is a marker of systemic inflammation that correlates with cardiac events. This study assessed the association between NLR and the presence of chronic coronary total occlusion (CTO).

Methods: The study population included 225 patients, a control group (n = 75), a coronary artery disease group (n = 75), and a CTO group (n = 75). NLR was compared in the three groups.

Results: NLR levels were significantly higher in the CTO than in the other two groups (p < 0.001). Bivariate correlation analysis showed a positive correlation between NLR and SYNTAX Score, and multivariate logistic regression analysis found that NLR was an independent predictor of CTO. ROC analysis showed that an NLR cut-off of 2.09 could distinguish between patients with and without CTO (AUC = 0.74; 95% CI, 0.68-0.81), with a specificity of 69.3% and a sensitivity of 61%.

Conclusion: NLR may be useful as a marker of CTO.

Show MeSH
Related in: MedlinePlus