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The relation between neutrophil-to-lymphocyte ratio and coronary chronic total occlusions.

Demir K, Avci A, Altunkeser BB, Yilmaz A, Keles F, Ersecgin A - BMC Cardiovasc Disord (2014)

Bottom Line: NLR was compared in the three groups.NLR levels were significantly higher in the CTO than in the other two groups (p < 0.001).Bivariate correlation analysis showed a positive correlation between NLR and SYNTAX Score, and multivariate logistic regression analysis found that NLR was an independent predictor of CTO.

View Article: PubMed Central - PubMed

Affiliation: Faculty of Medicine Cardiology Department, Selcuk University, 42075 Konya, Turkey. drkenan76@yahoo.com.

ABSTRACT

Background: Neutrophil-to-lymphocyte ratio (NLR) is a marker of systemic inflammation that correlates with cardiac events. This study assessed the association between NLR and the presence of chronic coronary total occlusion (CTO).

Methods: The study population included 225 patients, a control group (n = 75), a coronary artery disease group (n = 75), and a CTO group (n = 75). NLR was compared in the three groups.

Results: NLR levels were significantly higher in the CTO than in the other two groups (p < 0.001). Bivariate correlation analysis showed a positive correlation between NLR and SYNTAX Score, and multivariate logistic regression analysis found that NLR was an independent predictor of CTO. ROC analysis showed that an NLR cut-off of 2.09 could distinguish between patients with and without CTO (AUC = 0.74; 95% CI, 0.68-0.81), with a specificity of 69.3% and a sensitivity of 61%.

Conclusion: NLR may be useful as a marker of CTO.

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Related in: MedlinePlus

NLR levels among study groups.
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Fig1: NLR levels among study groups.

Mentions: The baseline characteristics of patients are summarized in Table 1. There were 75 patients (mean age of 58 ± 11, and 45.3% were male) in the control group, 75 patients (mean age of 63 ± 10, and 65.3% were male) in the CAD group, and 75 patients (mean age of 61 ± 8, and 88% were male) in the CTO group. Mean age was significantly higher in the CAD group (p = 0.01). The male patient ratio of CTO and CAD groups were higher than that of the control group. The prevalence of cardiovascular risk factors. such as diabetes mellitus, hyperlipidemia, and family history of CAD, were significantly higher in the CTO group than in other groups (p = 0.004, p < 0.001, and p < 0.001, respectively), but hypertension and smoking were similar in all the groups. The groups were similar in terms of hemoglobin levels and platelet count. WBC and neutrophil count were significantly higher in the CTO group; in contrast, the lymphocyte count was significantly lower in the CTO group (p = 0.001, p < 0.001, and p = 0.01, respectively). NLR levels were significantly higher in the CTO group (p < 0.001) (Figure 1). Also, Gensini score and SYNTAX score were significantly higher in the CTO group than in other groups (both p < 0.001).


The relation between neutrophil-to-lymphocyte ratio and coronary chronic total occlusions.

Demir K, Avci A, Altunkeser BB, Yilmaz A, Keles F, Ersecgin A - BMC Cardiovasc Disord (2014)

NLR levels among study groups.
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4195893&req=5

Fig1: NLR levels among study groups.
Mentions: The baseline characteristics of patients are summarized in Table 1. There were 75 patients (mean age of 58 ± 11, and 45.3% were male) in the control group, 75 patients (mean age of 63 ± 10, and 65.3% were male) in the CAD group, and 75 patients (mean age of 61 ± 8, and 88% were male) in the CTO group. Mean age was significantly higher in the CAD group (p = 0.01). The male patient ratio of CTO and CAD groups were higher than that of the control group. The prevalence of cardiovascular risk factors. such as diabetes mellitus, hyperlipidemia, and family history of CAD, were significantly higher in the CTO group than in other groups (p = 0.004, p < 0.001, and p < 0.001, respectively), but hypertension and smoking were similar in all the groups. The groups were similar in terms of hemoglobin levels and platelet count. WBC and neutrophil count were significantly higher in the CTO group; in contrast, the lymphocyte count was significantly lower in the CTO group (p = 0.001, p < 0.001, and p = 0.01, respectively). NLR levels were significantly higher in the CTO group (p < 0.001) (Figure 1). Also, Gensini score and SYNTAX score were significantly higher in the CTO group than in other groups (both p < 0.001).

Bottom Line: NLR was compared in the three groups.NLR levels were significantly higher in the CTO than in the other two groups (p < 0.001).Bivariate correlation analysis showed a positive correlation between NLR and SYNTAX Score, and multivariate logistic regression analysis found that NLR was an independent predictor of CTO.

View Article: PubMed Central - PubMed

Affiliation: Faculty of Medicine Cardiology Department, Selcuk University, 42075 Konya, Turkey. drkenan76@yahoo.com.

ABSTRACT

Background: Neutrophil-to-lymphocyte ratio (NLR) is a marker of systemic inflammation that correlates with cardiac events. This study assessed the association between NLR and the presence of chronic coronary total occlusion (CTO).

Methods: The study population included 225 patients, a control group (n = 75), a coronary artery disease group (n = 75), and a CTO group (n = 75). NLR was compared in the three groups.

Results: NLR levels were significantly higher in the CTO than in the other two groups (p < 0.001). Bivariate correlation analysis showed a positive correlation between NLR and SYNTAX Score, and multivariate logistic regression analysis found that NLR was an independent predictor of CTO. ROC analysis showed that an NLR cut-off of 2.09 could distinguish between patients with and without CTO (AUC = 0.74; 95% CI, 0.68-0.81), with a specificity of 69.3% and a sensitivity of 61%.

Conclusion: NLR may be useful as a marker of CTO.

Show MeSH
Related in: MedlinePlus