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Defining the concept of locally advanced squamous cell carcinoma of the vulva: a new perspective based on standardization of criteria and current evidence.

Aragona AM, Soderini AH, Cuneo NA - J Gynecol Oncol (2014)

Bottom Line: Grounded on cervical cancer experience, we are able to state that designing a tailored primary strategy based on clinically measurable adverse prognostic factors represents the cornerstone of therapy.This fact urged us to rethink about the real usefulness of the concept of locally advanced squamous cell carcinoma of the vulva.Finally, a standardized definition will help us compare the results obtained, which is extremely necessary given the worldwide low prevalence of this disease.

View Article: PubMed Central - PubMed

Affiliation: Department of Gynecologic Oncology, Oncology Hospital of Buenos Aires Marie Curie, Buenos Aires, Argentina.; Unit of Gynecologic Oncology, Donacion Francisco Santojanni Hospital, Buenos Aires, Argentina. alearagona2@gmail.com.

ABSTRACT
The phrase "locally advanced carcinoma of the vulva" has often been mentioned in the literature, though not accurately defined, or even leading to the interpretation overlapping. Grounded on cervical cancer experience, we are able to state that designing a tailored primary strategy based on clinically measurable adverse prognostic factors represents the cornerstone of therapy. This fact urged us to rethink about the real usefulness of the concept of locally advanced squamous cell carcinoma of the vulva. We will refer to this concept as a clinical entity emerging from a rigorous workup which is a valuable guiding tool in the context of a thorough debate about the best primary treatment approach to be used. Furthermore, bulky tumors of the vulva have been associated with a worse prognosis on several occasions. Some authors have questioned the fact that tumor size has not been considered in the staging system. Finally, a standardized definition will help us compare the results obtained, which is extremely necessary given the worldwide low prevalence of this disease.

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Related in: MedlinePlus

Authors recommendations for the management of probably locally advanced squamous cell carcinoma of the vulva (LASCCV): primary treatment of regional disease.
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Figure 2: Authors recommendations for the management of probably locally advanced squamous cell carcinoma of the vulva (LASCCV): primary treatment of regional disease.

Mentions: An ongoing prospective randomized phase III trial is being carried out at the Gynecologic Oncology Department of the Oncology Hospital of Buenos Aires Marie Curie comparing NCH followed by radical surgery vs. primary radical surgery in this high risk group of patients. Our current recommendations for the management of LASCCV appear in Figs. 1, 2.


Defining the concept of locally advanced squamous cell carcinoma of the vulva: a new perspective based on standardization of criteria and current evidence.

Aragona AM, Soderini AH, Cuneo NA - J Gynecol Oncol (2014)

Authors recommendations for the management of probably locally advanced squamous cell carcinoma of the vulva (LASCCV): primary treatment of regional disease.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4195295&req=5

Figure 2: Authors recommendations for the management of probably locally advanced squamous cell carcinoma of the vulva (LASCCV): primary treatment of regional disease.
Mentions: An ongoing prospective randomized phase III trial is being carried out at the Gynecologic Oncology Department of the Oncology Hospital of Buenos Aires Marie Curie comparing NCH followed by radical surgery vs. primary radical surgery in this high risk group of patients. Our current recommendations for the management of LASCCV appear in Figs. 1, 2.

Bottom Line: Grounded on cervical cancer experience, we are able to state that designing a tailored primary strategy based on clinically measurable adverse prognostic factors represents the cornerstone of therapy.This fact urged us to rethink about the real usefulness of the concept of locally advanced squamous cell carcinoma of the vulva.Finally, a standardized definition will help us compare the results obtained, which is extremely necessary given the worldwide low prevalence of this disease.

View Article: PubMed Central - PubMed

Affiliation: Department of Gynecologic Oncology, Oncology Hospital of Buenos Aires Marie Curie, Buenos Aires, Argentina.; Unit of Gynecologic Oncology, Donacion Francisco Santojanni Hospital, Buenos Aires, Argentina. alearagona2@gmail.com.

ABSTRACT
The phrase "locally advanced carcinoma of the vulva" has often been mentioned in the literature, though not accurately defined, or even leading to the interpretation overlapping. Grounded on cervical cancer experience, we are able to state that designing a tailored primary strategy based on clinically measurable adverse prognostic factors represents the cornerstone of therapy. This fact urged us to rethink about the real usefulness of the concept of locally advanced squamous cell carcinoma of the vulva. We will refer to this concept as a clinical entity emerging from a rigorous workup which is a valuable guiding tool in the context of a thorough debate about the best primary treatment approach to be used. Furthermore, bulky tumors of the vulva have been associated with a worse prognosis on several occasions. Some authors have questioned the fact that tumor size has not been considered in the staging system. Finally, a standardized definition will help us compare the results obtained, which is extremely necessary given the worldwide low prevalence of this disease.

Show MeSH
Related in: MedlinePlus