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Pemphigus vulgaris presented with cheilitis.

Abbas Z, Safaie Naraghi Z, Behrangi E - Case Rep Dermatol Med (2014)

Bottom Line: Patient showed excellent response and lesions resolved completely within 2 months.In one-year follow-up, there was no evidence of relapse or any additional lesion on the other sites.Conclusion.

View Article: PubMed Central - PubMed

Affiliation: Department of Dermatology, Razi Hospital, Tehran University of Medical Sciences, Vahdate Eslami Square, Vahdate Eslami Avenue, Tehran 11996, Iran.

ABSTRACT
Background. Pemphigus vulgaris is an autoimmune blistering disease affecting the mucous membrane and skin. In 50 to 70% of cases, the initial manifestations of pemphigus vulgaris are oral lesions which may be followed by skin lesions. But it is unusual for the disease to present with initial and solitary persistent lower lip lesions without progression to any other location. Main Observations. We report a 41-year-old woman with dry crusted lesions only on the lower lip, clinically resembling actinic cheilitis and erosive lichen planus, but histopathological evaluation showed unexpected results of suprabasal acantholysis and cleft compatible with pemphigus vulgaris. We treated her with intralesional triamcinolone 10 mg/mL for 2 sessions and 2 g cellcept daily. Patient showed excellent response and lesions resolved completely within 2 months. In one-year follow-up, there was no evidence of relapse or any additional lesion on the other sites. Conclusion. Cheilitis may be the initial and sole manifestation of pemphigus vulgaris. Localized and solitary lesions of pemphigus vulgaris can be treated and controlled without systemic corticosteroids.

No MeSH data available.


Related in: MedlinePlus

After 2-month follow-up (lesions resolved).
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fig3: After 2-month follow-up (lesions resolved).

Mentions: As the disease was mild and localized, we started cellcept 2 g daily along with 2 sessions of triamcinolone 10 mg/mL intralesional injections after performing initial necessary tests. Lesions were totally resolved within 2 months (Figure 3). After disease remission, treatment continued with cellcept 2 g daily for 1 year follow-up period. There was neither recurrence nor any new lesion elsewhere (Figure 4). Anti-Dsg 1 and anti-Dsg 3 values at the end of 6-month follow-up were 11 and 18.9 (positive >20), respectively.


Pemphigus vulgaris presented with cheilitis.

Abbas Z, Safaie Naraghi Z, Behrangi E - Case Rep Dermatol Med (2014)

After 2-month follow-up (lesions resolved).
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4195250&req=5

fig3: After 2-month follow-up (lesions resolved).
Mentions: As the disease was mild and localized, we started cellcept 2 g daily along with 2 sessions of triamcinolone 10 mg/mL intralesional injections after performing initial necessary tests. Lesions were totally resolved within 2 months (Figure 3). After disease remission, treatment continued with cellcept 2 g daily for 1 year follow-up period. There was neither recurrence nor any new lesion elsewhere (Figure 4). Anti-Dsg 1 and anti-Dsg 3 values at the end of 6-month follow-up were 11 and 18.9 (positive >20), respectively.

Bottom Line: Patient showed excellent response and lesions resolved completely within 2 months.In one-year follow-up, there was no evidence of relapse or any additional lesion on the other sites.Conclusion.

View Article: PubMed Central - PubMed

Affiliation: Department of Dermatology, Razi Hospital, Tehran University of Medical Sciences, Vahdate Eslami Square, Vahdate Eslami Avenue, Tehran 11996, Iran.

ABSTRACT
Background. Pemphigus vulgaris is an autoimmune blistering disease affecting the mucous membrane and skin. In 50 to 70% of cases, the initial manifestations of pemphigus vulgaris are oral lesions which may be followed by skin lesions. But it is unusual for the disease to present with initial and solitary persistent lower lip lesions without progression to any other location. Main Observations. We report a 41-year-old woman with dry crusted lesions only on the lower lip, clinically resembling actinic cheilitis and erosive lichen planus, but histopathological evaluation showed unexpected results of suprabasal acantholysis and cleft compatible with pemphigus vulgaris. We treated her with intralesional triamcinolone 10 mg/mL for 2 sessions and 2 g cellcept daily. Patient showed excellent response and lesions resolved completely within 2 months. In one-year follow-up, there was no evidence of relapse or any additional lesion on the other sites. Conclusion. Cheilitis may be the initial and sole manifestation of pemphigus vulgaris. Localized and solitary lesions of pemphigus vulgaris can be treated and controlled without systemic corticosteroids.

No MeSH data available.


Related in: MedlinePlus