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Pemphigus vulgaris presented with cheilitis.

Abbas Z, Safaie Naraghi Z, Behrangi E - Case Rep Dermatol Med (2014)

Bottom Line: Patient showed excellent response and lesions resolved completely within 2 months.In one-year follow-up, there was no evidence of relapse or any additional lesion on the other sites.Conclusion.

View Article: PubMed Central - PubMed

Affiliation: Department of Dermatology, Razi Hospital, Tehran University of Medical Sciences, Vahdate Eslami Square, Vahdate Eslami Avenue, Tehran 11996, Iran.

ABSTRACT
Background. Pemphigus vulgaris is an autoimmune blistering disease affecting the mucous membrane and skin. In 50 to 70% of cases, the initial manifestations of pemphigus vulgaris are oral lesions which may be followed by skin lesions. But it is unusual for the disease to present with initial and solitary persistent lower lip lesions without progression to any other location. Main Observations. We report a 41-year-old woman with dry crusted lesions only on the lower lip, clinically resembling actinic cheilitis and erosive lichen planus, but histopathological evaluation showed unexpected results of suprabasal acantholysis and cleft compatible with pemphigus vulgaris. We treated her with intralesional triamcinolone 10 mg/mL for 2 sessions and 2 g cellcept daily. Patient showed excellent response and lesions resolved completely within 2 months. In one-year follow-up, there was no evidence of relapse or any additional lesion on the other sites. Conclusion. Cheilitis may be the initial and sole manifestation of pemphigus vulgaris. Localized and solitary lesions of pemphigus vulgaris can be treated and controlled without systemic corticosteroids.

No MeSH data available.


Related in: MedlinePlus

Scaly crusted lesions on lower lip (before biopsy).
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fig1: Scaly crusted lesions on lower lip (before biopsy).

Mentions: A 41-year-old woman was referred to the dermatology clinic of Razi Hospital, Tehran, Iran, with a 6-month history of erosions and crusts on lower lip accompanied by pain and burning sensation (Figure 1). Further physical examination did not reveal any lesion on the skin and mucosa. Multiple topical treatments had been used by the patient in this period but lesions did not improve.


Pemphigus vulgaris presented with cheilitis.

Abbas Z, Safaie Naraghi Z, Behrangi E - Case Rep Dermatol Med (2014)

Scaly crusted lesions on lower lip (before biopsy).
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4195250&req=5

fig1: Scaly crusted lesions on lower lip (before biopsy).
Mentions: A 41-year-old woman was referred to the dermatology clinic of Razi Hospital, Tehran, Iran, with a 6-month history of erosions and crusts on lower lip accompanied by pain and burning sensation (Figure 1). Further physical examination did not reveal any lesion on the skin and mucosa. Multiple topical treatments had been used by the patient in this period but lesions did not improve.

Bottom Line: Patient showed excellent response and lesions resolved completely within 2 months.In one-year follow-up, there was no evidence of relapse or any additional lesion on the other sites.Conclusion.

View Article: PubMed Central - PubMed

Affiliation: Department of Dermatology, Razi Hospital, Tehran University of Medical Sciences, Vahdate Eslami Square, Vahdate Eslami Avenue, Tehran 11996, Iran.

ABSTRACT
Background. Pemphigus vulgaris is an autoimmune blistering disease affecting the mucous membrane and skin. In 50 to 70% of cases, the initial manifestations of pemphigus vulgaris are oral lesions which may be followed by skin lesions. But it is unusual for the disease to present with initial and solitary persistent lower lip lesions without progression to any other location. Main Observations. We report a 41-year-old woman with dry crusted lesions only on the lower lip, clinically resembling actinic cheilitis and erosive lichen planus, but histopathological evaluation showed unexpected results of suprabasal acantholysis and cleft compatible with pemphigus vulgaris. We treated her with intralesional triamcinolone 10 mg/mL for 2 sessions and 2 g cellcept daily. Patient showed excellent response and lesions resolved completely within 2 months. In one-year follow-up, there was no evidence of relapse or any additional lesion on the other sites. Conclusion. Cheilitis may be the initial and sole manifestation of pemphigus vulgaris. Localized and solitary lesions of pemphigus vulgaris can be treated and controlled without systemic corticosteroids.

No MeSH data available.


Related in: MedlinePlus