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Postmenopausal choriocarcinoma: A rare case report.

Samal SK, Rathod S, Ghose S - J Midlife Health (2014)

Bottom Line: Histopathology revealed uterine choriocarcinoma.She was treated with EMACO regimen following which her beta-hCG returned to normal in five cycles.The patient is under regular follow-up and is doing well.

View Article: PubMed Central - PubMed

Affiliation: Department of Obstetrics and Gynaecology, Mahatma Gandhi Medical College and Research Institute, Pondicherry, India.

ABSTRACT
Choriocarcinoma is a highly malignant epithelial tumor originating from trophoblast. It primarily occurs during the fertile period. Postmenopausal uterine choriocarcinoma is very rare. We present a case of choriocarcinoma in a postmenopausal lady developing 5 years after menopause. She presented with heavy postmenopausal bleeding along with passage of vesicles per vaginum. Serum beta-hCG was 96,484 mIU/ml. Emergency abdominal hysterectomy with bilateral salpingo-ooperectomy was done due to intractable bleeding following suction and evacuation. Histopathology revealed uterine choriocarcinoma. She was treated with EMACO regimen following which her beta-hCG returned to normal in five cycles. The patient is under regular follow-up and is doing well.

No MeSH data available.


Related in: MedlinePlus

Cut section of uterus showing soft brown polyoid structures
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Figure 2: Cut section of uterus showing soft brown polyoid structures

Mentions: Grossly uterus was 14 × 10 × 9 cm and cut section showed cavity filled with soft dark brown polyps [Figure 2]. Microscopic examination revealed wide areas of hemorrhagic necrosis with clusters of trophoblastic cells having intermediate trophoblasts, bizzare nuclei among these cells having increased mitotic activity with dilated vesicular spaces lined by trophoblasts and filled with fibrinoid material. Villus pattern was completely absent and there was no evidence of myometrial invasion. Histopathology of uterus was suggestive of choriocarcinoma whereas cervix showed features of chronic cervicitis.


Postmenopausal choriocarcinoma: A rare case report.

Samal SK, Rathod S, Ghose S - J Midlife Health (2014)

Cut section of uterus showing soft brown polyoid structures
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4195191&req=5

Figure 2: Cut section of uterus showing soft brown polyoid structures
Mentions: Grossly uterus was 14 × 10 × 9 cm and cut section showed cavity filled with soft dark brown polyps [Figure 2]. Microscopic examination revealed wide areas of hemorrhagic necrosis with clusters of trophoblastic cells having intermediate trophoblasts, bizzare nuclei among these cells having increased mitotic activity with dilated vesicular spaces lined by trophoblasts and filled with fibrinoid material. Villus pattern was completely absent and there was no evidence of myometrial invasion. Histopathology of uterus was suggestive of choriocarcinoma whereas cervix showed features of chronic cervicitis.

Bottom Line: Histopathology revealed uterine choriocarcinoma.She was treated with EMACO regimen following which her beta-hCG returned to normal in five cycles.The patient is under regular follow-up and is doing well.

View Article: PubMed Central - PubMed

Affiliation: Department of Obstetrics and Gynaecology, Mahatma Gandhi Medical College and Research Institute, Pondicherry, India.

ABSTRACT
Choriocarcinoma is a highly malignant epithelial tumor originating from trophoblast. It primarily occurs during the fertile period. Postmenopausal uterine choriocarcinoma is very rare. We present a case of choriocarcinoma in a postmenopausal lady developing 5 years after menopause. She presented with heavy postmenopausal bleeding along with passage of vesicles per vaginum. Serum beta-hCG was 96,484 mIU/ml. Emergency abdominal hysterectomy with bilateral salpingo-ooperectomy was done due to intractable bleeding following suction and evacuation. Histopathology revealed uterine choriocarcinoma. She was treated with EMACO regimen following which her beta-hCG returned to normal in five cycles. The patient is under regular follow-up and is doing well.

No MeSH data available.


Related in: MedlinePlus