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Postmenopausal choriocarcinoma: A rare case report.

Samal SK, Rathod S, Ghose S - J Midlife Health (2014)

Bottom Line: Histopathology revealed uterine choriocarcinoma.She was treated with EMACO regimen following which her beta-hCG returned to normal in five cycles.The patient is under regular follow-up and is doing well.

View Article: PubMed Central - PubMed

Affiliation: Department of Obstetrics and Gynaecology, Mahatma Gandhi Medical College and Research Institute, Pondicherry, India.

ABSTRACT
Choriocarcinoma is a highly malignant epithelial tumor originating from trophoblast. It primarily occurs during the fertile period. Postmenopausal uterine choriocarcinoma is very rare. We present a case of choriocarcinoma in a postmenopausal lady developing 5 years after menopause. She presented with heavy postmenopausal bleeding along with passage of vesicles per vaginum. Serum beta-hCG was 96,484 mIU/ml. Emergency abdominal hysterectomy with bilateral salpingo-ooperectomy was done due to intractable bleeding following suction and evacuation. Histopathology revealed uterine choriocarcinoma. She was treated with EMACO regimen following which her beta-hCG returned to normal in five cycles. The patient is under regular follow-up and is doing well.

No MeSH data available.


Related in: MedlinePlus

Bleeding with the passage of vesicles
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Figure 1: Bleeding with the passage of vesicles

Mentions: On general examination she was severely pale with pulse rate 110/minute and blood pressure of 90/60 mm of Hg. Clinical examination revealed uterus of 16-weeks size, cervix was long, soft; os open with passage of fleshy vesicles [Figure 1]. She was resuscitated with crystalloids and three units of blood transfusion. Blood investigations showed hemoglobin to be 6.4 gm% and serum beta-hCG was 96,484 mIU/ml. Chest X ray, thyroid profile, liver function, renal function tests and coagulation profile were within normal limits. Ultrasound showed a large moderately echogenic mass with numerous cystic spaces seen filling the central uterine cavity with bilateral normal ovaries. She was diagnosed as a case of gestational trophoblastic disease and suction and evacuation was planned. During evacuation there was intractable bleeding for which emergency total abdominal hysterectomy with bilateral salpingo-oophorectomy was done.


Postmenopausal choriocarcinoma: A rare case report.

Samal SK, Rathod S, Ghose S - J Midlife Health (2014)

Bleeding with the passage of vesicles
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4195191&req=5

Figure 1: Bleeding with the passage of vesicles
Mentions: On general examination she was severely pale with pulse rate 110/minute and blood pressure of 90/60 mm of Hg. Clinical examination revealed uterus of 16-weeks size, cervix was long, soft; os open with passage of fleshy vesicles [Figure 1]. She was resuscitated with crystalloids and three units of blood transfusion. Blood investigations showed hemoglobin to be 6.4 gm% and serum beta-hCG was 96,484 mIU/ml. Chest X ray, thyroid profile, liver function, renal function tests and coagulation profile were within normal limits. Ultrasound showed a large moderately echogenic mass with numerous cystic spaces seen filling the central uterine cavity with bilateral normal ovaries. She was diagnosed as a case of gestational trophoblastic disease and suction and evacuation was planned. During evacuation there was intractable bleeding for which emergency total abdominal hysterectomy with bilateral salpingo-oophorectomy was done.

Bottom Line: Histopathology revealed uterine choriocarcinoma.She was treated with EMACO regimen following which her beta-hCG returned to normal in five cycles.The patient is under regular follow-up and is doing well.

View Article: PubMed Central - PubMed

Affiliation: Department of Obstetrics and Gynaecology, Mahatma Gandhi Medical College and Research Institute, Pondicherry, India.

ABSTRACT
Choriocarcinoma is a highly malignant epithelial tumor originating from trophoblast. It primarily occurs during the fertile period. Postmenopausal uterine choriocarcinoma is very rare. We present a case of choriocarcinoma in a postmenopausal lady developing 5 years after menopause. She presented with heavy postmenopausal bleeding along with passage of vesicles per vaginum. Serum beta-hCG was 96,484 mIU/ml. Emergency abdominal hysterectomy with bilateral salpingo-ooperectomy was done due to intractable bleeding following suction and evacuation. Histopathology revealed uterine choriocarcinoma. She was treated with EMACO regimen following which her beta-hCG returned to normal in five cycles. The patient is under regular follow-up and is doing well.

No MeSH data available.


Related in: MedlinePlus