Limits...
Granulosa cell tumor of ovary: A clinicopathological study of four cases with brief review of literature.

Vani BR, Geethamala K, Geetha RL, Srinivasa MV - J Midlife Health (2014)

Bottom Line: Histologically, variety of patterns like diffuse, trabecular, cords, spindle and clear cells were noted.Both Call-Exner bodies and nuclear grooves were observed in all cases.Staging and histopathology helps in prediction of survival.

View Article: PubMed Central - PubMed

Affiliation: Department of Pathology, Employees State Insurance Corporation Medical College and Post Graduate Institute of Medical Science and Research, Rajajinagar, Bangalore, Karnataka, India.

ABSTRACT

Introduction: Adult granulosa cell tumor (GCT) is a rare ovarian malignancy having good prognosis in comparison with other epithelial tumors. The study aims to collect data of all granulosa cell tumors diagnosed in ESIC Medical College & PGIMSR, Rajajinagar, Bangalore over the last 3 years and to describe the patient profile, ultrasonographic and various histopathological features.

Materials and methods: A total of 4 granulosa cell tumors were diagnosed in ESIC Medical College & PGIMSR, Rajajinagar, Bangalore during the period from June 2010 to June 2013. The patient's age, clinical manifestations, radiological and histopathological findings were evaluated.

Results: All 4 patients were diagnosed as adult granulosa cell tumor, three of four cases were in premenopausal age group and one case was in perimenopausal age. The clinical manifestations were menorrhagia and abdominal pain. Ultrasonographically, 2 cases of granulosa cell tumors were both solid and cystic and one case each was either solid or cystic. Histologically, variety of patterns like diffuse, trabecular, cords, spindle and clear cells were noted. Both Call-Exner bodies and nuclear grooves were observed in all cases. All four cases showed simple hyperplasia without atypia endometrial findings. Follow up on all patients revealed no evidence of recurrence.

Conclusion: Granulosa cell tumor of the ovary is a rare ovarian entity. The important prognostic factor is staging of the tumor. Staging and histopathology helps in prediction of survival. Also diligent endometrial pathology has to be sorted to rule out endometrial carcinoma.

No MeSH data available.


Related in: MedlinePlus

H and E photomicrograph of scrape cytology shows vague Call-Exner bodies (×40). Inset shows nuclear grooves (×100)
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4195186&req=5

Figure 2: H and E photomicrograph of scrape cytology shows vague Call-Exner bodies (×40). Inset shows nuclear grooves (×100)

Mentions: A 37-year female presented to the gynaecology outpatient block with history of menorrhagia. On examination the patient was pale looking and her hemoglobin levels were 8 gm%. Other vitals were stable. Ultrasonogram (USG) revealed left adnexal solid-cystic mass with mild heterogeneity and diagnosis of ovarian tumor was offered. After preoperative investigation the patient was subjected to total abdominal hysterectomy with bilateral salphingo-opharectomy (TAH with BSO). On receipt of the specimen, uterus, cervix was unremarkable with the left ovarian encapsulated mass measuring 12 × 9 × 7 cm and stretched out tube over it. Cut section of the lesion showed solid grey white to yellow tumor with tiny multiple cysts, few of which were filled with blood. No normal ovarian stroma was made out. Other adnexae were unremarkable. On histopathological examination (HPE), mass revealed tumor cells being arranged in cords, solid sheets, trabecular pattern and at places microfollicular pattern with Call-Exner bodies. Individual tumor cells are round to oval with nuclear grooves and mitotic figures of 2/10 high power field. Final diagnosis of GCT — Stage 1A — (T1a, N0, M0-TNM and Federation International de Gynecologie et d'Obsterique (FIGO)) was given. Endometrium showed simple hyperplasia without atypia. [Figures 1 and 2]


Granulosa cell tumor of ovary: A clinicopathological study of four cases with brief review of literature.

Vani BR, Geethamala K, Geetha RL, Srinivasa MV - J Midlife Health (2014)

H and E photomicrograph of scrape cytology shows vague Call-Exner bodies (×40). Inset shows nuclear grooves (×100)
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4195186&req=5

Figure 2: H and E photomicrograph of scrape cytology shows vague Call-Exner bodies (×40). Inset shows nuclear grooves (×100)
Mentions: A 37-year female presented to the gynaecology outpatient block with history of menorrhagia. On examination the patient was pale looking and her hemoglobin levels were 8 gm%. Other vitals were stable. Ultrasonogram (USG) revealed left adnexal solid-cystic mass with mild heterogeneity and diagnosis of ovarian tumor was offered. After preoperative investigation the patient was subjected to total abdominal hysterectomy with bilateral salphingo-opharectomy (TAH with BSO). On receipt of the specimen, uterus, cervix was unremarkable with the left ovarian encapsulated mass measuring 12 × 9 × 7 cm and stretched out tube over it. Cut section of the lesion showed solid grey white to yellow tumor with tiny multiple cysts, few of which were filled with blood. No normal ovarian stroma was made out. Other adnexae were unremarkable. On histopathological examination (HPE), mass revealed tumor cells being arranged in cords, solid sheets, trabecular pattern and at places microfollicular pattern with Call-Exner bodies. Individual tumor cells are round to oval with nuclear grooves and mitotic figures of 2/10 high power field. Final diagnosis of GCT — Stage 1A — (T1a, N0, M0-TNM and Federation International de Gynecologie et d'Obsterique (FIGO)) was given. Endometrium showed simple hyperplasia without atypia. [Figures 1 and 2]

Bottom Line: Histologically, variety of patterns like diffuse, trabecular, cords, spindle and clear cells were noted.Both Call-Exner bodies and nuclear grooves were observed in all cases.Staging and histopathology helps in prediction of survival.

View Article: PubMed Central - PubMed

Affiliation: Department of Pathology, Employees State Insurance Corporation Medical College and Post Graduate Institute of Medical Science and Research, Rajajinagar, Bangalore, Karnataka, India.

ABSTRACT

Introduction: Adult granulosa cell tumor (GCT) is a rare ovarian malignancy having good prognosis in comparison with other epithelial tumors. The study aims to collect data of all granulosa cell tumors diagnosed in ESIC Medical College & PGIMSR, Rajajinagar, Bangalore over the last 3 years and to describe the patient profile, ultrasonographic and various histopathological features.

Materials and methods: A total of 4 granulosa cell tumors were diagnosed in ESIC Medical College & PGIMSR, Rajajinagar, Bangalore during the period from June 2010 to June 2013. The patient's age, clinical manifestations, radiological and histopathological findings were evaluated.

Results: All 4 patients were diagnosed as adult granulosa cell tumor, three of four cases were in premenopausal age group and one case was in perimenopausal age. The clinical manifestations were menorrhagia and abdominal pain. Ultrasonographically, 2 cases of granulosa cell tumors were both solid and cystic and one case each was either solid or cystic. Histologically, variety of patterns like diffuse, trabecular, cords, spindle and clear cells were noted. Both Call-Exner bodies and nuclear grooves were observed in all cases. All four cases showed simple hyperplasia without atypia endometrial findings. Follow up on all patients revealed no evidence of recurrence.

Conclusion: Granulosa cell tumor of the ovary is a rare ovarian entity. The important prognostic factor is staging of the tumor. Staging and histopathology helps in prediction of survival. Also diligent endometrial pathology has to be sorted to rule out endometrial carcinoma.

No MeSH data available.


Related in: MedlinePlus