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Retrospective analysis of antibiotic resistance pattern to urinary pathogens in a Tertiary Care Hospital in South India.

Somashekara SC, Deepalaxmi S, Jagannath N, Ramesh B, Laveesh MR, Govindadas D - J Basic Clin Pharm (2014)

Bottom Line: Therefore, the knowledge on the frequency of the causative microorganisms and their susceptibility to various antibiotics are necessary for a better therapeutic outcome.Nalidixic acid, ampicillin, co-trimoxazole, and first-generation fluoroquinolones have limited value for the treatment of UTI.Routine monitoring of drug resistance pattern will help to identify the resistance trends regionally.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmacology, Malabar Medical College and Research Centre, Modakkallur, Kozhikode, Kerala, India.

ABSTRACT

Context: The distribution of uropathogens and their susceptibility pattern to antibiotics vary regionally and even in the same region, they change over time. Therefore, the knowledge on the frequency of the causative microorganisms and their susceptibility to various antibiotics are necessary for a better therapeutic outcome.

Aim: The aim was to study the frequency and distribution of uropathogens and their resistance pattern to antibiotics in a tertiary care hospital.

Settings and design: Retrospective study for a period of 1 year from January 2011 to December 2011 in a tertiary care hospital.

Materials and methods: The culture and sensitivity data of the uropathogens from suspected cases of UTI were collected from the records of Microbiology Department for study period. Midstream urine samples were processed for microscopy and culture, and the organisms were identified by standard methods. Antibiotic susceptibility was carried out by Kirby-Bauer disk diffusion method according to Clinical and Laboratory Standards Institute guidelines. Descriptive statistics were used to analyze the data.

Results: Of 896 urine samples, 348 (38.84%) samples were positive for urine culture. Escherichia coli (52.59%) was the most common organism followed by Klebsiella. E. coli was least resistant to imipenem (8%) and amikacin (16%) and was highly resistant to co-trimoxazole (69%) and ampicillin (86%). Klebsiella species were least resistant to amikacin (26%) and were highly resistant to ampicillin (92%). The overall resistance pattern of antibiotics to uropathogens was the highest to nalidixic acid (79%) followed by co-trimoxazole (75%) and ampicillin (72%). Good susceptibility was seen with imipenem and cephalosporins.

Conclusion: E. coli is still the most common uropathogen. Nalidixic acid, ampicillin, co-trimoxazole, and first-generation fluoroquinolones have limited value for the treatment of UTI. Sensitivity to imipenem and amikacin are still retained and may be prescribed for complicated UTI. Routine monitoring of drug resistance pattern will help to identify the resistance trends regionally. This will help in the empirical treatment of UTIs to the clinicians.

No MeSH data available.


Related in: MedlinePlus

Prevalence of uropathogens isolated
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Figure 1: Prevalence of uropathogens isolated

Mentions: Of 896 urine samples analyzed, 548 (61.16%) were from females and 348 (38.84%) were from males. Of 896 urine samples, 348 (38.84%) samples were positive for urine culture. Escherichia coli (52.59%) was the most common organism followed by Klebsiella, Citrobacter and Staphylococcus aureus. Proteus and Acinetobacter showed the least infectivity pattern accounting only for 1.44% of the organisms isolated. Candida albicans growth was seen in 7.47% of the samples. The pattern of bacterial agents isolated is as shown in Figure 1.


Retrospective analysis of antibiotic resistance pattern to urinary pathogens in a Tertiary Care Hospital in South India.

Somashekara SC, Deepalaxmi S, Jagannath N, Ramesh B, Laveesh MR, Govindadas D - J Basic Clin Pharm (2014)

Prevalence of uropathogens isolated
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4194940&req=5

Figure 1: Prevalence of uropathogens isolated
Mentions: Of 896 urine samples analyzed, 548 (61.16%) were from females and 348 (38.84%) were from males. Of 896 urine samples, 348 (38.84%) samples were positive for urine culture. Escherichia coli (52.59%) was the most common organism followed by Klebsiella, Citrobacter and Staphylococcus aureus. Proteus and Acinetobacter showed the least infectivity pattern accounting only for 1.44% of the organisms isolated. Candida albicans growth was seen in 7.47% of the samples. The pattern of bacterial agents isolated is as shown in Figure 1.

Bottom Line: Therefore, the knowledge on the frequency of the causative microorganisms and their susceptibility to various antibiotics are necessary for a better therapeutic outcome.Nalidixic acid, ampicillin, co-trimoxazole, and first-generation fluoroquinolones have limited value for the treatment of UTI.Routine monitoring of drug resistance pattern will help to identify the resistance trends regionally.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmacology, Malabar Medical College and Research Centre, Modakkallur, Kozhikode, Kerala, India.

ABSTRACT

Context: The distribution of uropathogens and their susceptibility pattern to antibiotics vary regionally and even in the same region, they change over time. Therefore, the knowledge on the frequency of the causative microorganisms and their susceptibility to various antibiotics are necessary for a better therapeutic outcome.

Aim: The aim was to study the frequency and distribution of uropathogens and their resistance pattern to antibiotics in a tertiary care hospital.

Settings and design: Retrospective study for a period of 1 year from January 2011 to December 2011 in a tertiary care hospital.

Materials and methods: The culture and sensitivity data of the uropathogens from suspected cases of UTI were collected from the records of Microbiology Department for study period. Midstream urine samples were processed for microscopy and culture, and the organisms were identified by standard methods. Antibiotic susceptibility was carried out by Kirby-Bauer disk diffusion method according to Clinical and Laboratory Standards Institute guidelines. Descriptive statistics were used to analyze the data.

Results: Of 896 urine samples, 348 (38.84%) samples were positive for urine culture. Escherichia coli (52.59%) was the most common organism followed by Klebsiella. E. coli was least resistant to imipenem (8%) and amikacin (16%) and was highly resistant to co-trimoxazole (69%) and ampicillin (86%). Klebsiella species were least resistant to amikacin (26%) and were highly resistant to ampicillin (92%). The overall resistance pattern of antibiotics to uropathogens was the highest to nalidixic acid (79%) followed by co-trimoxazole (75%) and ampicillin (72%). Good susceptibility was seen with imipenem and cephalosporins.

Conclusion: E. coli is still the most common uropathogen. Nalidixic acid, ampicillin, co-trimoxazole, and first-generation fluoroquinolones have limited value for the treatment of UTI. Sensitivity to imipenem and amikacin are still retained and may be prescribed for complicated UTI. Routine monitoring of drug resistance pattern will help to identify the resistance trends regionally. This will help in the empirical treatment of UTIs to the clinicians.

No MeSH data available.


Related in: MedlinePlus