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Administration of bisphosphonate (ibandronate) impedes molar tooth movement in rabbits: A radiographic assessment.

Venkataramana V, Kumar SS, Reddy BV, Cherukuri AS, Sigamani KR, Chandrasekhar G - J Pharm Bioallied Sci (2014)

Bottom Line: Individually, each animal's radiograph was traced manually and superimposed.The molar tooth movement was measured with the help of a standard metric scale.The Student's t-test has been done to compare the mean values of Group-1 (4.650 ± 0.363) and Group-2 (2.030 ± 0.291) and the difference was statistically significant (P < 0.001).

View Article: PubMed Central - PubMed

Affiliation: Department of Orthodontics, Panineeya Mahavidhyalaya Institute of Dental Sciences, Dilshuknagar, Hyderabad, Andhra Pradesh, India.

ABSTRACT

Introduction: Bisphosphonate (Bp)-ibandronate is a pharmacological agent, exhibits antiosteoclastic or antiresorptive activity and used to treat osteolytic or osteopenic disorders. BP-ibandronate may also interfere during orthodontic tooth movement. The aim of this study was to examine the influence of locally administered Bp-ibandronate on experimental tooth movement in rabbits.

Materials and methods: Twenty rabbits were divided into two groups- "10" served as Group-1 (control) and other "10" as Group-2 (experimental). Both groups received nickel-titanium closed coil springs with 100 g force between mandibular molar and incisors. Group-1 animals received 1 ml normal saline and Group-2 animals received ibandronate solution (0.3 mg/kg body weight) locally, mesial to the mandibular molar on the 1(st), 7(th), and 14(th) day of the experiment. A total of "40" lateral cephalograms were taken from both groups on the 1(st) and 21(st) day using a digital X-ray unit (Siemens X-ray systems, 300 mA Pleomophos analog, 2008, Germany). Individually, each animal's radiograph was traced manually and superimposed. The molar tooth movement was measured with the help of a standard metric scale.

Results: The Student's t-test has been done to compare the mean values of Group-1 (4.650 ± 0.363) and Group-2 (2.030 ± 0.291) and the difference was statistically significant (P < 0.001).

Conclusion: The retarded molar tooth movement was noticed in local drug administered rabbits, which could be beneficial in orthodontics to control the undesired tooth movement.

No MeSH data available.


Superimposed radiographic tracing of Group-1 (control) showing greater amount of molar tooth movement (distance between M1 and M2)
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Figure 5: Superimposed radiographic tracing of Group-1 (control) showing greater amount of molar tooth movement (distance between M1 and M2)

Mentions: Both groups of animals were exposed to radiation individually on the 1st and 21st days, and totally “40” lateral cephalic radiographs were produced using method previously described. The cephalic X-ray films were exposed using a digital Siemens 300 mA Pleomorphism analog digital X-ray unit. The exposure time (0.4-0.5 s) and the power settings (60-70 kV, 10 mA) were standardized to all animals. The X-rays were taken with the left side of the head of the animal facing the X-ray tube at a standardized distance of 60 cm away from the tube with animal lying in a supine position [Figure 3]. This technique has been adopted from the previous study.[36] Cephalic radiographs were traced manually using acetate paper and land marks were pointed with micro tip lead pencil [Figure 4]. Individually each animal's lateral cephalic radiographs were superimposed and the magnitude of molar tooth movement in the mesial direction was measured manually using standard metric scale based on two reference points that is, a mesio-occlusal tip of the second molar (M1) to the disto-occlusal tip of the first molar (M2) [Figures 5 and 6].


Administration of bisphosphonate (ibandronate) impedes molar tooth movement in rabbits: A radiographic assessment.

Venkataramana V, Kumar SS, Reddy BV, Cherukuri AS, Sigamani KR, Chandrasekhar G - J Pharm Bioallied Sci (2014)

Superimposed radiographic tracing of Group-1 (control) showing greater amount of molar tooth movement (distance between M1 and M2)
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4157260&req=5

Figure 5: Superimposed radiographic tracing of Group-1 (control) showing greater amount of molar tooth movement (distance between M1 and M2)
Mentions: Both groups of animals were exposed to radiation individually on the 1st and 21st days, and totally “40” lateral cephalic radiographs were produced using method previously described. The cephalic X-ray films were exposed using a digital Siemens 300 mA Pleomorphism analog digital X-ray unit. The exposure time (0.4-0.5 s) and the power settings (60-70 kV, 10 mA) were standardized to all animals. The X-rays were taken with the left side of the head of the animal facing the X-ray tube at a standardized distance of 60 cm away from the tube with animal lying in a supine position [Figure 3]. This technique has been adopted from the previous study.[36] Cephalic radiographs were traced manually using acetate paper and land marks were pointed with micro tip lead pencil [Figure 4]. Individually each animal's lateral cephalic radiographs were superimposed and the magnitude of molar tooth movement in the mesial direction was measured manually using standard metric scale based on two reference points that is, a mesio-occlusal tip of the second molar (M1) to the disto-occlusal tip of the first molar (M2) [Figures 5 and 6].

Bottom Line: Individually, each animal's radiograph was traced manually and superimposed.The molar tooth movement was measured with the help of a standard metric scale.The Student's t-test has been done to compare the mean values of Group-1 (4.650 ± 0.363) and Group-2 (2.030 ± 0.291) and the difference was statistically significant (P < 0.001).

View Article: PubMed Central - PubMed

Affiliation: Department of Orthodontics, Panineeya Mahavidhyalaya Institute of Dental Sciences, Dilshuknagar, Hyderabad, Andhra Pradesh, India.

ABSTRACT

Introduction: Bisphosphonate (Bp)-ibandronate is a pharmacological agent, exhibits antiosteoclastic or antiresorptive activity and used to treat osteolytic or osteopenic disorders. BP-ibandronate may also interfere during orthodontic tooth movement. The aim of this study was to examine the influence of locally administered Bp-ibandronate on experimental tooth movement in rabbits.

Materials and methods: Twenty rabbits were divided into two groups- "10" served as Group-1 (control) and other "10" as Group-2 (experimental). Both groups received nickel-titanium closed coil springs with 100 g force between mandibular molar and incisors. Group-1 animals received 1 ml normal saline and Group-2 animals received ibandronate solution (0.3 mg/kg body weight) locally, mesial to the mandibular molar on the 1(st), 7(th), and 14(th) day of the experiment. A total of "40" lateral cephalograms were taken from both groups on the 1(st) and 21(st) day using a digital X-ray unit (Siemens X-ray systems, 300 mA Pleomophos analog, 2008, Germany). Individually, each animal's radiograph was traced manually and superimposed. The molar tooth movement was measured with the help of a standard metric scale.

Results: The Student's t-test has been done to compare the mean values of Group-1 (4.650 ± 0.363) and Group-2 (2.030 ± 0.291) and the difference was statistically significant (P < 0.001).

Conclusion: The retarded molar tooth movement was noticed in local drug administered rabbits, which could be beneficial in orthodontics to control the undesired tooth movement.

No MeSH data available.