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(175)Yb-TTHMP as a good candidate for bone pain palliation and substitute of other radiopharmaceuticals.

Safarzadeh L - Indian J Nucl Med (2014)

Bottom Line: Biodistribution studies in normal rats were carried out.The results showed favorable biodistribution features of (175)Yb-TTHMP, indicating significant accumulation in bone tissues compared with clinically used bone-seeking radiopharmaceuticals.This research presents (175)Yb-TTHMP can be a good candidate for bone pain palliation and substitute of other radiopharmaceuticals, however, further biological studies in other mammals are still needed.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiation Application Engineering, Shahid Beheshti University, Tehran, Iran.

ABSTRACT
Bone metastasis is one of the most frequent causes of pain in cancer patients. Different radioisotopes such as P-32, Sm-153, Ho-166, Lu-177, and Re-186 with several chemical ligands as ethylenediaminetetramethylene phosphonic acid (EDTMP), 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetramethylene phosphonic acid (DOTMP), and propylenediaminetetramethylene phosphonate (PDTMP) are recommended for bone pain palliation. In this work, (175)Yb-triethylenetetraminehexamethylene phosphonic acid (TTHMP) was produced as a proper alternative to other radiopharmaceuticals. Relatively long half-life (T1/2 = 4.18 days), maximum energy beta particle Eβ =470 keV (86.5%), low abundance gamma emission 396 keV (6.4%), 286 keV (3.01%), 113.8 keV (1.88%) and low cost are considered advantageous of Yb-175 are to wider usage of this isotope; in addition, TTHMP is an ideal carrier moiety for bone metastases. Production, quality control, and biodistribution studies of (175)Yb-TTHMP were targeted. Yb-175 chloride was obtained by thermal neutron bombardment of a natural Yb2O3 sample at Tehran Research Reactor (TRR), radiolabeling was completed in 1 h by the addition of TTHMP at the room temperature and pH was 7.5-8, radiochemical purity was higher than 95%. Biodistribution studies in normal rats were carried out. The results showed favorable biodistribution features of (175)Yb-TTHMP, indicating significant accumulation in bone tissues compared with clinically used bone-seeking radiopharmaceuticals. This research presents (175)Yb-TTHMP can be a good candidate for bone pain palliation and substitute of other radiopharmaceuticals, however, further biological studies in other mammals are still needed.

No MeSH data available.


Related in: MedlinePlus

Percentage of injected dose per gram of 175YbCl3 in rats
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Figure 3: Percentage of injected dose per gram of 175YbCl3 in rats

Mentions: The tissue distribution of 175YbCl3 and 175Yb-TTHMP determined in rats over 8 days is shown in Figures 3 and 4, respectively. Specific activity of different organs was calculated as the percentage of injected dose per gram using NaI (Tl) detector. It can be seen from Figure 3 accumulation of free Yb3+ cation in the vital organs, that is, kidney, liver, lung, spleen, and heart are appreciable. Figure 4 demonstrates favorable features of 175Yb-TTHMP; such as, significant bone uptake-retention and rapid blood clearance.


(175)Yb-TTHMP as a good candidate for bone pain palliation and substitute of other radiopharmaceuticals.

Safarzadeh L - Indian J Nucl Med (2014)

Percentage of injected dose per gram of 175YbCl3 in rats
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4157185&req=5

Figure 3: Percentage of injected dose per gram of 175YbCl3 in rats
Mentions: The tissue distribution of 175YbCl3 and 175Yb-TTHMP determined in rats over 8 days is shown in Figures 3 and 4, respectively. Specific activity of different organs was calculated as the percentage of injected dose per gram using NaI (Tl) detector. It can be seen from Figure 3 accumulation of free Yb3+ cation in the vital organs, that is, kidney, liver, lung, spleen, and heart are appreciable. Figure 4 demonstrates favorable features of 175Yb-TTHMP; such as, significant bone uptake-retention and rapid blood clearance.

Bottom Line: Biodistribution studies in normal rats were carried out.The results showed favorable biodistribution features of (175)Yb-TTHMP, indicating significant accumulation in bone tissues compared with clinically used bone-seeking radiopharmaceuticals.This research presents (175)Yb-TTHMP can be a good candidate for bone pain palliation and substitute of other radiopharmaceuticals, however, further biological studies in other mammals are still needed.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiation Application Engineering, Shahid Beheshti University, Tehran, Iran.

ABSTRACT
Bone metastasis is one of the most frequent causes of pain in cancer patients. Different radioisotopes such as P-32, Sm-153, Ho-166, Lu-177, and Re-186 with several chemical ligands as ethylenediaminetetramethylene phosphonic acid (EDTMP), 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetramethylene phosphonic acid (DOTMP), and propylenediaminetetramethylene phosphonate (PDTMP) are recommended for bone pain palliation. In this work, (175)Yb-triethylenetetraminehexamethylene phosphonic acid (TTHMP) was produced as a proper alternative to other radiopharmaceuticals. Relatively long half-life (T1/2 = 4.18 days), maximum energy beta particle Eβ =470 keV (86.5%), low abundance gamma emission 396 keV (6.4%), 286 keV (3.01%), 113.8 keV (1.88%) and low cost are considered advantageous of Yb-175 are to wider usage of this isotope; in addition, TTHMP is an ideal carrier moiety for bone metastases. Production, quality control, and biodistribution studies of (175)Yb-TTHMP were targeted. Yb-175 chloride was obtained by thermal neutron bombardment of a natural Yb2O3 sample at Tehran Research Reactor (TRR), radiolabeling was completed in 1 h by the addition of TTHMP at the room temperature and pH was 7.5-8, radiochemical purity was higher than 95%. Biodistribution studies in normal rats were carried out. The results showed favorable biodistribution features of (175)Yb-TTHMP, indicating significant accumulation in bone tissues compared with clinically used bone-seeking radiopharmaceuticals. This research presents (175)Yb-TTHMP can be a good candidate for bone pain palliation and substitute of other radiopharmaceuticals, however, further biological studies in other mammals are still needed.

No MeSH data available.


Related in: MedlinePlus