Limits...
Testosterone Restoration by Enclomiphene Citrate in Men with Secondary Hypogonadism: Pharmacodynamics and Pharmacokinetics.

Wiehle R, Cunningham GR, Pitteloud N, Wike J, Hsu K, Fontenot GK, Rosner M, Dwyer A, Podolski J - BJU Int. (2013)

Bottom Line: Enclomiphene and transdermal testosterone increased levels of TT within two weeks, but they had opposite effects on FSH and LH Treatment with enclomiphene did not significantly affect levels of TSH, ACTH, cortisol, lipids, or bone markers.Both transdermal testosterone and enclomiphene citrate decreased IGF-1 levels (p<0.05) but suppression was greater in the enclomiphene citrate groups.The effects on LH and TT persisted for at least one week after stopping treatment.

View Article: PubMed Central - PubMed

Affiliation: Repros Therapeutics Inc, Houston, TX.

No MeSH data available.


Related in: MedlinePlus

Time course of effects on serum total testosterone. Figure shows the levels of serum total testosterone found before and after treatment with daily doses of enclomiphene citrate 6.25 mg (open squares), enclomiphene citrate 12.5 mg (green squares), enclomiphene citrate 25 mg (red squares) or transdermal testosterone (orange triangles). TT, total testosterone.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4155868&req=5

fig06: Time course of effects on serum total testosterone. Figure shows the levels of serum total testosterone found before and after treatment with daily doses of enclomiphene citrate 6.25 mg (open squares), enclomiphene citrate 12.5 mg (green squares), enclomiphene citrate 25 mg (red squares) or transdermal testosterone (orange triangles). TT, total testosterone.

Mentions: The time course of the serum total testosterone over the entire study is shown in Fig. 6 for the ITT population. There was no difference among the groups at the first or second qualifying visits (week 2, P = 0.74, anova; week 0, P = 0.23, Kruskal–Wallis test, respectively). Total testosterone levels after 2 weeks of treatment for the two highest doses of enclomiphene citrate and transdermal testosterone were similar. Total testosterone levels increased significantly in all groups at 2 weeks when compared with baseline, but the serum total testosterone for the transdermal testosterone group and the enclomiphene citrate 25 mg group were significantly higher than for the enclomiphene citrate 6.25 mg group (P = 0.025 and P = 0.016, t-test). A steady state, defined here by serum total testosterone values >400 ng/dL, appeared after 4 weeks of treatment with both agents. There were no significant changes from week 2 to 4 or from week 4 to 6 for any group.


Testosterone Restoration by Enclomiphene Citrate in Men with Secondary Hypogonadism: Pharmacodynamics and Pharmacokinetics.

Wiehle R, Cunningham GR, Pitteloud N, Wike J, Hsu K, Fontenot GK, Rosner M, Dwyer A, Podolski J - BJU Int. (2013)

Time course of effects on serum total testosterone. Figure shows the levels of serum total testosterone found before and after treatment with daily doses of enclomiphene citrate 6.25 mg (open squares), enclomiphene citrate 12.5 mg (green squares), enclomiphene citrate 25 mg (red squares) or transdermal testosterone (orange triangles). TT, total testosterone.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4155868&req=5

fig06: Time course of effects on serum total testosterone. Figure shows the levels of serum total testosterone found before and after treatment with daily doses of enclomiphene citrate 6.25 mg (open squares), enclomiphene citrate 12.5 mg (green squares), enclomiphene citrate 25 mg (red squares) or transdermal testosterone (orange triangles). TT, total testosterone.
Mentions: The time course of the serum total testosterone over the entire study is shown in Fig. 6 for the ITT population. There was no difference among the groups at the first or second qualifying visits (week 2, P = 0.74, anova; week 0, P = 0.23, Kruskal–Wallis test, respectively). Total testosterone levels after 2 weeks of treatment for the two highest doses of enclomiphene citrate and transdermal testosterone were similar. Total testosterone levels increased significantly in all groups at 2 weeks when compared with baseline, but the serum total testosterone for the transdermal testosterone group and the enclomiphene citrate 25 mg group were significantly higher than for the enclomiphene citrate 6.25 mg group (P = 0.025 and P = 0.016, t-test). A steady state, defined here by serum total testosterone values >400 ng/dL, appeared after 4 weeks of treatment with both agents. There were no significant changes from week 2 to 4 or from week 4 to 6 for any group.

Bottom Line: Enclomiphene and transdermal testosterone increased levels of TT within two weeks, but they had opposite effects on FSH and LH Treatment with enclomiphene did not significantly affect levels of TSH, ACTH, cortisol, lipids, or bone markers.Both transdermal testosterone and enclomiphene citrate decreased IGF-1 levels (p<0.05) but suppression was greater in the enclomiphene citrate groups.The effects on LH and TT persisted for at least one week after stopping treatment.

View Article: PubMed Central - PubMed

Affiliation: Repros Therapeutics Inc, Houston, TX.

No MeSH data available.


Related in: MedlinePlus