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Inferences about the global scenario of human T-cell lymphotropic virus type 1 infection using data mining of viral sequences.

Araujo TH, Barreto FK, Alcântara LC, Miranda AC - Mem. Inst. Oswaldo Cruz (2014)

Bottom Line: Ethnicity data are very scarce.Regarding clinical status data, 29% of the sequences were generated from TSP/HAM and 67.8% from healthy carrier individuals.Although the data mining enabled some inferences about specific aspects of HTLV-1 infection to be made, due to the relative scarcity of data of available sequences, it was not possible to delineate a global scenario of HTLV-1 infection.

View Article: PubMed Central - PubMed

Affiliation: Centro de Pesquisa Gonçalo Moniz-Fiocru, Salvador, BA, Brasil.

ABSTRACT
Human T-cell lymphotropic virus type 1 (HTLV-1) is mainly associated with two diseases: tropical spastic paraparesis/HTLV-1-associated myelopathy (TSP/HAM) and adult T-cell leukaemia/lymphoma. This retrovirus infects five-10 million individuals throughout the world. Previously, we developed a database that annotates sequence data from GenBank and the present study aimed to describe the clinical, molecular and epidemiological scenarios of HTLV-1 infection through the stored sequences in this database. A total of 2,545 registered complete and partial sequences of HTLV-1 were collected and 1,967 (77.3%) of those sequences represented unique isolates. Among these isolates, 93% contained geographic origin information and only 39% were related to any clinical status. A total of 1,091 sequences contained information about the geographic origin and viral subtype and 93% of these sequences were identified as subtype "a". Ethnicity data are very scarce. Regarding clinical status data, 29% of the sequences were generated from TSP/HAM and 67.8% from healthy carrier individuals. Although the data mining enabled some inferences about specific aspects of HTLV-1 infection to be made, due to the relative scarcity of data of available sequences, it was not possible to delineate a global scenario of HTLV-1 infection.

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: distribution (%) of human T-cell lymphotropic virus type 1 sequencesamong the countries in South America.
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f02: : distribution (%) of human T-cell lymphotropic virus type 1 sequencesamong the countries in South America.

Mentions: Geographic origin, viral subtype and clinical status among viralsequences - Among the 2,058 viral sequences, 1,914 (93%) were associatedwith geographic origin in the GenBank notes. Fig.1 shows the distribution of HTLV-1 sequences among different geographicregions: 1.6% of the sequences originated from HTLV-1 isolates from North America, 2.4%from Oceania, 3% from Europe, 3.3% from Central America, 17.7% from Africa, 32% fromAsia and 40% from South America. With regard to the South America sequences, most of theisolates were from HTLV-1 infections in Brazil (55%) and Argentina (22.1%), as shown inFig. 2.


Inferences about the global scenario of human T-cell lymphotropic virus type 1 infection using data mining of viral sequences.

Araujo TH, Barreto FK, Alcântara LC, Miranda AC - Mem. Inst. Oswaldo Cruz (2014)

: distribution (%) of human T-cell lymphotropic virus type 1 sequencesamong the countries in South America.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4155846&req=5

f02: : distribution (%) of human T-cell lymphotropic virus type 1 sequencesamong the countries in South America.
Mentions: Geographic origin, viral subtype and clinical status among viralsequences - Among the 2,058 viral sequences, 1,914 (93%) were associatedwith geographic origin in the GenBank notes. Fig.1 shows the distribution of HTLV-1 sequences among different geographicregions: 1.6% of the sequences originated from HTLV-1 isolates from North America, 2.4%from Oceania, 3% from Europe, 3.3% from Central America, 17.7% from Africa, 32% fromAsia and 40% from South America. With regard to the South America sequences, most of theisolates were from HTLV-1 infections in Brazil (55%) and Argentina (22.1%), as shown inFig. 2.

Bottom Line: Ethnicity data are very scarce.Regarding clinical status data, 29% of the sequences were generated from TSP/HAM and 67.8% from healthy carrier individuals.Although the data mining enabled some inferences about specific aspects of HTLV-1 infection to be made, due to the relative scarcity of data of available sequences, it was not possible to delineate a global scenario of HTLV-1 infection.

View Article: PubMed Central - PubMed

Affiliation: Centro de Pesquisa Gonçalo Moniz-Fiocru, Salvador, BA, Brasil.

ABSTRACT
Human T-cell lymphotropic virus type 1 (HTLV-1) is mainly associated with two diseases: tropical spastic paraparesis/HTLV-1-associated myelopathy (TSP/HAM) and adult T-cell leukaemia/lymphoma. This retrovirus infects five-10 million individuals throughout the world. Previously, we developed a database that annotates sequence data from GenBank and the present study aimed to describe the clinical, molecular and epidemiological scenarios of HTLV-1 infection through the stored sequences in this database. A total of 2,545 registered complete and partial sequences of HTLV-1 were collected and 1,967 (77.3%) of those sequences represented unique isolates. Among these isolates, 93% contained geographic origin information and only 39% were related to any clinical status. A total of 1,091 sequences contained information about the geographic origin and viral subtype and 93% of these sequences were identified as subtype "a". Ethnicity data are very scarce. Regarding clinical status data, 29% of the sequences were generated from TSP/HAM and 67.8% from healthy carrier individuals. Although the data mining enabled some inferences about specific aspects of HTLV-1 infection to be made, due to the relative scarcity of data of available sequences, it was not possible to delineate a global scenario of HTLV-1 infection.

Show MeSH
Related in: MedlinePlus