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A method to obtain the thermal parameters and the photothermal transduction efficiency in an optical hyperthermia device based on laser irradiation of gold nanoparticles.

Sánchez López de Pablo C, Olmedo JJ, Rosales AM, Ramírez Hernández N, Del Pozo Guerrero F - Nanoscale Res Lett (2014)

Bottom Line: By knowing this parameter, it is possible to increase the effectiveness of the treatments, thanks to the possibility of predicting the response of the device depending on the working configuration.As an example, the thermal behavior of two different kinds of nanoparticles is compared.The results show that, under identical conditions, the use of PEGylated gold nanorods allows for a more efficient heating compared with bare nanorods, and therefore, it results in a more effective therapy.

View Article: PubMed Central - HTML - PubMed

Affiliation: Centre for Biomedical Technology (CTB), Universidad Politécnica de Madrid (UPM), Campus de Montegancedo, Pozuelo de Alarcón, 28223 Madrid, Spain ; Biomedical Research Networking Center (CIBER), C/ Monforte de Lemos 3-5, Pabellón 11, 28029 Madrid, Spain.

ABSTRACT
Optical hyperthermia systems based on the laser irradiation of gold nanorods seem to be a promising tool in the development of therapies against cancer. After a proof of concept in which the authors demonstrated the efficiency of this kind of systems, a modeling process based on an equivalent thermal-electric circuit has been carried out to determine the thermal parameters of the system and an energy balance obtained from the time-dependent heating and cooling temperature curves of the irradiated samples in order to obtain the photothermal transduction efficiency. By knowing this parameter, it is possible to increase the effectiveness of the treatments, thanks to the possibility of predicting the response of the device depending on the working configuration. As an example, the thermal behavior of two different kinds of nanoparticles is compared. The results show that, under identical conditions, the use of PEGylated gold nanorods allows for a more efficient heating compared with bare nanorods, and therefore, it results in a more effective therapy.

No MeSH data available.


Related in: MedlinePlus

Electrical equivalent circuit used to obtain the thermal parameters of the optical hyperthermia device.
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Figure 2: Electrical equivalent circuit used to obtain the thermal parameters of the optical hyperthermia device.

Mentions: In order to determine the parameters that characterize and describe the thermal behavior of our hyperthermia device, it is needed to develop a thermal model, which can be raised from the resolution of an equivalent electric circuit (Figure 2).


A method to obtain the thermal parameters and the photothermal transduction efficiency in an optical hyperthermia device based on laser irradiation of gold nanoparticles.

Sánchez López de Pablo C, Olmedo JJ, Rosales AM, Ramírez Hernández N, Del Pozo Guerrero F - Nanoscale Res Lett (2014)

Electrical equivalent circuit used to obtain the thermal parameters of the optical hyperthermia device.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4155392&req=5

Figure 2: Electrical equivalent circuit used to obtain the thermal parameters of the optical hyperthermia device.
Mentions: In order to determine the parameters that characterize and describe the thermal behavior of our hyperthermia device, it is needed to develop a thermal model, which can be raised from the resolution of an equivalent electric circuit (Figure 2).

Bottom Line: By knowing this parameter, it is possible to increase the effectiveness of the treatments, thanks to the possibility of predicting the response of the device depending on the working configuration.As an example, the thermal behavior of two different kinds of nanoparticles is compared.The results show that, under identical conditions, the use of PEGylated gold nanorods allows for a more efficient heating compared with bare nanorods, and therefore, it results in a more effective therapy.

View Article: PubMed Central - HTML - PubMed

Affiliation: Centre for Biomedical Technology (CTB), Universidad Politécnica de Madrid (UPM), Campus de Montegancedo, Pozuelo de Alarcón, 28223 Madrid, Spain ; Biomedical Research Networking Center (CIBER), C/ Monforte de Lemos 3-5, Pabellón 11, 28029 Madrid, Spain.

ABSTRACT
Optical hyperthermia systems based on the laser irradiation of gold nanorods seem to be a promising tool in the development of therapies against cancer. After a proof of concept in which the authors demonstrated the efficiency of this kind of systems, a modeling process based on an equivalent thermal-electric circuit has been carried out to determine the thermal parameters of the system and an energy balance obtained from the time-dependent heating and cooling temperature curves of the irradiated samples in order to obtain the photothermal transduction efficiency. By knowing this parameter, it is possible to increase the effectiveness of the treatments, thanks to the possibility of predicting the response of the device depending on the working configuration. As an example, the thermal behavior of two different kinds of nanoparticles is compared. The results show that, under identical conditions, the use of PEGylated gold nanorods allows for a more efficient heating compared with bare nanorods, and therefore, it results in a more effective therapy.

No MeSH data available.


Related in: MedlinePlus