BMP-regulated exosomes from Drosophila male reproductive glands reprogram female behavior.
Bottom Line: Male reproductive glands secrete signals into seminal fluid to facilitate reproductive success.Exosome release was required to inhibit female remating behavior, suggesting that exosomes are downstream effectors of BMP signaling.These results demonstrate a new function for the MVB-exosome pathway in the reproductive tract that appears to be conserved across evolution.
Affiliation: Department of Physiology, Anatomy and Genetics and Nuffield Department of Surgical Sciences, University of Oxford, Oxford OX1 3QX, England, UK.Show MeSH
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Mentions: Because BMP signaling drives SC growth, as measured by relative size of SC versus neighboring MC nuclei (Leiblich et al., 2012), we tested whether exosome formation or secretion might be involved in this. Interestingly, although nuclei of SCs expressing either ALiX-RNAi or Rab11DN were reduced in size, nuclear size was increased in Hrs-RNAi–expressing SCs (Fig. 9). This suggests that ESCRT-dependent ILV formation is not required for SC growth.
Affiliation: Department of Physiology, Anatomy and Genetics and Nuffield Department of Surgical Sciences, University of Oxford, Oxford OX1 3QX, England, UK.